Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600183113> ?p ?o ?g. }
- W2600183113 endingPage "500" @default.
- W2600183113 startingPage "491" @default.
- W2600183113 abstract "Consistent reports indicate that hypertension is a particularly common finding in black populations. Hypertension occurs at younger ages and is often more severe in terms of blood pressure levels and organ damage than in whites, resulting in a higher incidence of cardiovascular disease and mortality. This review provides an outline of recent advances in the pathophysiological understanding of blood pressure elevation and the consequences thereof in black populations in Africa. This is set against the backdrop of populations undergoing demanding and rapid demographic transition, where infection with the human immunodeficiency virus predominates, and where under and over-nutrition coexist. Collectively, recent findings from Africa illustrate an increased lifetime risk to hypertension from foetal life onwards. From young ages black populations display early endothelial dysfunction, increased vascular tone and reactivity, microvascular structural adaptions as well as increased aortic stiffness resulting in elevated central and brachial blood pressures during the day and night, when compared to whites. Together with knowledge on the contributions of sympathetic activation and abnormal renal sodium handling, these pathophysiological adaptations result in subclinical and clinical organ damage at younger ages. This overall enhanced understanding on the determinants of blood pressure elevation in blacks encourages (a) novel approaches to assess and manage hypertension in Africa better, (b) further scientific discovery to develop more effective prevention and treatment strategies and (c) policymakers and health advocates to collectively contribute in creating health-promoting environments in Africa." @default.
- W2600183113 created "2017-04-07" @default.
- W2600183113 creator A5002584172 @default.
- W2600183113 creator A5002982938 @default.
- W2600183113 creator A5010963277 @default.
- W2600183113 creator A5011521546 @default.
- W2600183113 creator A5015413391 @default.
- W2600183113 creator A5051664627 @default.
- W2600183113 creator A5057729977 @default.
- W2600183113 creator A5066370664 @default.
- W2600183113 creator A5069606144 @default.
- W2600183113 creator A5077466609 @default.
- W2600183113 creator A5079491393 @default.
- W2600183113 creator A5081550087 @default.
- W2600183113 creator A5084405906 @default.
- W2600183113 date "2017-03-23" @default.
- W2600183113 modified "2023-10-06" @default.
- W2600183113 title "Recent advances in understanding hypertension development in sub-Saharan Africa" @default.
- W2600183113 cites W1142586400 @default.
- W2600183113 cites W1502027120 @default.
- W2600183113 cites W1502898407 @default.
- W2600183113 cites W1514053250 @default.
- W2600183113 cites W1554289550 @default.
- W2600183113 cites W1566922005 @default.
- W2600183113 cites W1617145133 @default.
- W2600183113 cites W1948897642 @default.
- W2600183113 cites W1963644429 @default.
- W2600183113 cites W1965508034 @default.
- W2600183113 cites W1966596113 @default.
- W2600183113 cites W1968604512 @default.
- W2600183113 cites W1970240791 @default.
- W2600183113 cites W1970537005 @default.
- W2600183113 cites W1971947579 @default.
- W2600183113 cites W1975825386 @default.
- W2600183113 cites W1976556720 @default.
- W2600183113 cites W1977031293 @default.
- W2600183113 cites W1977480665 @default.
- W2600183113 cites W1980145275 @default.
- W2600183113 cites W1986071500 @default.
- W2600183113 cites W1987297212 @default.
- W2600183113 cites W1989483002 @default.
- W2600183113 cites W1992017261 @default.
- W2600183113 cites W1998310232 @default.
- W2600183113 cites W1998875974 @default.
- W2600183113 cites W2007407144 @default.
- W2600183113 cites W2014742814 @default.
- W2600183113 cites W20181957 @default.
- W2600183113 cites W2018335030 @default.
- W2600183113 cites W2019855264 @default.
- W2600183113 cites W2020091161 @default.
- W2600183113 cites W2023912847 @default.
- W2600183113 cites W2026862331 @default.
- W2600183113 cites W2028147850 @default.
- W2600183113 cites W2031072276 @default.
- W2600183113 cites W2039560710 @default.
- W2600183113 cites W2041916071 @default.
- W2600183113 cites W2043610326 @default.
- W2600183113 cites W2044800764 @default.
- W2600183113 cites W2045389876 @default.
- W2600183113 cites W2047686677 @default.
- W2600183113 cites W2049261146 @default.
- W2600183113 cites W2051617591 @default.
- W2600183113 cites W2053096032 @default.
- W2600183113 cites W2053434245 @default.
- W2600183113 cites W2059609348 @default.
- W2600183113 cites W2059750535 @default.
- W2600183113 cites W2068041274 @default.
- W2600183113 cites W2068737548 @default.
- W2600183113 cites W2069749827 @default.
- W2600183113 cites W2070744197 @default.
- W2600183113 cites W2071499846 @default.
- W2600183113 cites W2076621773 @default.
- W2600183113 cites W2077788237 @default.
- W2600183113 cites W2080567113 @default.
- W2600183113 cites W2082004744 @default.
- W2600183113 cites W2082196122 @default.
- W2600183113 cites W2087461939 @default.
- W2600183113 cites W2089120971 @default.
- W2600183113 cites W2090157411 @default.
- W2600183113 cites W2091582362 @default.
- W2600183113 cites W2093776283 @default.
- W2600183113 cites W2094404165 @default.
- W2600183113 cites W2100771352 @default.
- W2600183113 cites W2101619401 @default.
- W2600183113 cites W2102867242 @default.
- W2600183113 cites W2103161362 @default.
- W2600183113 cites W2103858121 @default.
- W2600183113 cites W2105905549 @default.
- W2600183113 cites W2107556744 @default.
- W2600183113 cites W2107711375 @default.
- W2600183113 cites W2110754184 @default.
- W2600183113 cites W2111031497 @default.
- W2600183113 cites W2112262501 @default.
- W2600183113 cites W2114123359 @default.
- W2600183113 cites W2114123443 @default.
- W2600183113 cites W2114919940 @default.
- W2600183113 cites W2115292178 @default.
- W2600183113 cites W2115645735 @default.