Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600201917> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2600201917 endingPage "1588" @default.
- W2600201917 startingPage "1580" @default.
- W2600201917 abstract "잔대의 70% 에탄올 추출물은 강한 항산화 효과 및 산화적 스트레스 조건에서 뇌신경세포 사멸 억제 효과가 있었다. 6개의 분획물 중에 잔대 추출물의 클로로포름 분획물(ATCH)은 높은 DPPH 라디칼 소거작용 및 세포 내 활성산소종(ROS) 소거작용을 가지고 있었고 H₂O₂에 대항하여 뇌신경세포(SK-N-SH) 보호 효과가 가장 뛰어났다. 활성이 가장 우수한 클로로포름 분획물을 대상으로 주요 물질을 순수분리한 후 ¹H-NMR, SUP13/SUPC-NMR 그리고 EI mass spectra를 이용하여 화학구조를 분석한 결과 phytosterols(β-sitosterol과 daucosterol)이라는 것을 알 수 있었다. β-Sitosterol과 daucosterol 역시 산화적 스트레스에 대항하여 SK-NSH세포를 보호하는 작용이 있었다. AT-CH 그리고 이것으로부터 분리된 화합물은 p38 경로를 저해하였다. 이들 결과는 AT-CH는 p38 경로를 저해하고 세포 내 ROS 소거작용에 의해 산화적 스트레스로부터 뇌신경세포 보호 효과를 가질 것이라 제안하였다." @default.
- W2600201917 created "2017-04-07" @default.
- W2600201917 creator A5000869158 @default.
- W2600201917 creator A5064682028 @default.
- W2600201917 creator A5065680403 @default.
- W2600201917 creator A5079070649 @default.
- W2600201917 date "2016-11-30" @default.
- W2600201917 modified "2023-10-14" @default.
- W2600201917 title "Antioxidative and Neuroprotective Effects of Extract and Fractions from Adenophora triphylla" @default.
- W2600201917 cites W1688167503 @default.
- W2600201917 cites W1961117612 @default.
- W2600201917 cites W1971611456 @default.
- W2600201917 cites W1975359028 @default.
- W2600201917 cites W1985418340 @default.
- W2600201917 cites W1999975108 @default.
- W2600201917 cites W2015671168 @default.
- W2600201917 cites W2027638357 @default.
- W2600201917 cites W2058519257 @default.
- W2600201917 cites W2093658250 @default.
- W2600201917 cites W2102480714 @default.
- W2600201917 cites W2109249615 @default.
- W2600201917 cites W2164864932 @default.
- W2600201917 cites W2245415021 @default.
- W2600201917 cites W2265961601 @default.
- W2600201917 cites W2908455979 @default.
- W2600201917 doi "https://doi.org/10.3746/jkfn.2016.45.11.1580" @default.
- W2600201917 hasPublicationYear "2016" @default.
- W2600201917 type Work @default.
- W2600201917 sameAs 2600201917 @default.
- W2600201917 citedByCount "3" @default.
- W2600201917 countsByYear W26002019172019 @default.
- W2600201917 countsByYear W26002019172022 @default.
- W2600201917 crossrefType "journal-article" @default.
- W2600201917 hasAuthorship W2600201917A5000869158 @default.
- W2600201917 hasAuthorship W2600201917A5064682028 @default.
- W2600201917 hasAuthorship W2600201917A5065680403 @default.
- W2600201917 hasAuthorship W2600201917A5079070649 @default.
- W2600201917 hasConcept C185592680 @default.
- W2600201917 hasConcept C2778004101 @default.
- W2600201917 hasConcept C2779532046 @default.
- W2600201917 hasConcept C2779700632 @default.
- W2600201917 hasConcept C2781401929 @default.
- W2600201917 hasConcept C43617362 @default.
- W2600201917 hasConcept C55493867 @default.
- W2600201917 hasConcept C556039675 @default.
- W2600201917 hasConcept C71924100 @default.
- W2600201917 hasConceptScore W2600201917C185592680 @default.
- W2600201917 hasConceptScore W2600201917C2778004101 @default.
- W2600201917 hasConceptScore W2600201917C2779532046 @default.
- W2600201917 hasConceptScore W2600201917C2779700632 @default.
- W2600201917 hasConceptScore W2600201917C2781401929 @default.
- W2600201917 hasConceptScore W2600201917C43617362 @default.
- W2600201917 hasConceptScore W2600201917C55493867 @default.
- W2600201917 hasConceptScore W2600201917C556039675 @default.
- W2600201917 hasConceptScore W2600201917C71924100 @default.
- W2600201917 hasIssue "11" @default.
- W2600201917 hasLocation W26002019171 @default.
- W2600201917 hasOpenAccess W2600201917 @default.
- W2600201917 hasPrimaryLocation W26002019171 @default.
- W2600201917 hasRelatedWork W2037951041 @default.
- W2600201917 hasRelatedWork W2184358985 @default.
- W2600201917 hasRelatedWork W2213510413 @default.
- W2600201917 hasRelatedWork W2489030968 @default.
- W2600201917 hasRelatedWork W2594341035 @default.
- W2600201917 hasRelatedWork W2617523712 @default.
- W2600201917 hasRelatedWork W2764841094 @default.
- W2600201917 hasRelatedWork W2792658027 @default.
- W2600201917 hasRelatedWork W3010718286 @default.
- W2600201917 hasRelatedWork W2783805346 @default.
- W2600201917 hasVolume "45" @default.
- W2600201917 isParatext "false" @default.
- W2600201917 isRetracted "false" @default.
- W2600201917 magId "2600201917" @default.
- W2600201917 workType "article" @default.