FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600254018> ?p ?o ?g. }

• W2600254018 endingPage "1297" @default.
• W2600254018 startingPage "1279" @default.
• W2600254018 abstract "Abstract The retinoblastoma protein (Rb), which typically functions as a transcriptional repressor of E2F‐regulated genes, represents a major control hub of the cell cycle. Here, we show that loss of the Arabidopsis Rb homolog RETINOBLASTOMA ‐ RELATED 1 ( RBR 1) leads to cell death, especially upon exposure to genotoxic drugs such as the environmental toxin aluminum. While cell death can be suppressed by reduced cell‐proliferation rates, rbr1 mutant cells exhibit elevated levels of DNA lesions, indicating a direct role of RBR 1 in the DNA ‐damage response ( DDR ). Consistent with its role as a transcriptional repressor, we find that RBR 1 directly binds to and represses key DDR genes such as RADIATION SENSITIVE 51 ( RAD 51), leaving it unclear why rbr1 mutants are hypersensitive to DNA damage. However, we find that RBR 1 is also required for RAD 51 localization to DNA lesions. We further show that RBR 1 is itself targeted to DNA break sites in a CDKB 1 activity‐dependent manner and partially co‐localizes with RAD 51 at damage sites. Taken together, these results implicate RBR 1 in the assembly of DNA ‐bound repair complexes, in addition to its canonical function as a transcriptional regulator." @default.
• W2600254018 created "2017-04-07" @default.
• W2600254018 creator A5015168350 @default.
• W2600254018 creator A5017553414 @default.
• W2600254018 creator A5036347122 @default.
• W2600254018 creator A5041540725 @default.
• W2600254018 creator A5071386076 @default.
• W2600254018 creator A5082418737 @default.
• W2600254018 creator A5084006202 @default.
• W2600254018 date "2017-03-20" @default.
• W2600254018 modified "2023-10-16" @default.
• W2600254018 title "The retinoblastoma homolog <scp>RBR</scp>1 mediates localization of the repair protein <scp>RAD</scp>51 to <scp>DNA</scp> lesions in <i>Arabidopsis</i>" @default.
• W2600254018 cites W1105935516 @default.
• W2600254018 cites W1490483000 @default.
• W2600254018 cites W1504228927 @default.
• W2600254018 cites W1577404300 @default.
• W2600254018 cites W1868830276 @default.
• W2600254018 cites W1966599992 @default.
• W2600254018 cites W1970825176 @default.
• W2600254018 cites W1975248044 @default.
• W2600254018 cites W1978450240 @default.
• W2600254018 cites W1979212911 @default.
• W2600254018 cites W1982077520 @default.
• W2600254018 cites W1984579945 @default.
• W2600254018 cites W1986960362 @default.
• W2600254018 cites W1988608958 @default.
• W2600254018 cites W1989665806 @default.
• W2600254018 cites W1995463919 @default.
• W2600254018 cites W1999649555 @default.
• W2600254018 cites W2003152543 @default.
• W2600254018 cites W2008411508 @default.
• W2600254018 cites W2008951081 @default.
• W2600254018 cites W2012939857 @default.
• W2600254018 cites W2014965747 @default.
• W2600254018 cites W2026702893 @default.
• W2600254018 cites W2027501274 @default.
• W2600254018 cites W2028612056 @default.
• W2600254018 cites W2032265315 @default.
• W2600254018 cites W2032298890 @default.
• W2600254018 cites W2032532082 @default.
• W2600254018 cites W2033927221 @default.
• W2600254018 cites W2034380296 @default.
• W2600254018 cites W2036284590 @default.
• W2600254018 cites W2046350139 @default.
• W2600254018 cites W2046594289 @default.
• W2600254018 cites W2046989021 @default.
• W2600254018 cites W2051535801 @default.
• W2600254018 cites W2062030742 @default.
• W2600254018 cites W2063268362 @default.
• W2600254018 cites W2063623731 @default.
• W2600254018 cites W2071605593 @default.
• W2600254018 cites W2073101700 @default.
• W2600254018 cites W2073682280 @default.
• W2600254018 cites W2080295315 @default.
• W2600254018 cites W2086675262 @default.
• W2600254018 cites W2088600219 @default.
• W2600254018 cites W2093190888 @default.
• W2600254018 cites W2094032519 @default.
• W2600254018 cites W2095637989 @default.
• W2600254018 cites W2097352995 @default.
• W2600254018 cites W2098220565 @default.
• W2600254018 cites W2099529441 @default.
• W2600254018 cites W2106596862 @default.
• W2600254018 cites W2109960177 @default.
• W2600254018 cites W2112036583 @default.
• W2600254018 cites W2116082487 @default.
• W2600254018 cites W2116516380 @default.
• W2600254018 cites W2117687474 @default.
• W2600254018 cites W2118514901 @default.
• W2600254018 cites W2120132776 @default.
• W2600254018 cites W2122672347 @default.
• W2600254018 cites W2122914905 @default.
• W2600254018 cites W2126514850 @default.
• W2600254018 cites W2129480177 @default.
• W2600254018 cites W2130604691 @default.
• W2600254018 cites W2130734186 @default.
• W2600254018 cites W2131463690 @default.
• W2600254018 cites W2135129680 @default.
• W2600254018 cites W2136283388 @default.
• W2600254018 cites W2136309995 @default.
• W2600254018 cites W2138581811 @default.
• W2600254018 cites W2139514279 @default.
• W2600254018 cites W2152866503 @default.
• W2600254018 cites W2153047151 @default.
• W2600254018 cites W2157779996 @default.
• W2600254018 cites W2158495108 @default.
• W2600254018 cites W2158561017 @default.
• W2600254018 cites W2159185219 @default.
• W2600254018 cites W2166703629 @default.
• W2600254018 cites W2166713348 @default.
• W2600254018 cites W2169439222 @default.
• W2600254018 cites W2169817991 @default.
• W2600254018 cites W2169927110 @default.
• W2600254018 cites W2170214084 @default.
• W2600254018 cites W2257531205 @default.
• W2600254018 cites W2488734769 @default.
• W2600254018 cites W2526924091 @default.
• W2600254018 cites W2597867873 @default.

• next