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- W2600254958 abstract "Amphibian populations are declining worldwide, evidently as theimplication of environmental contaminants and infectiousdiseases. Generally, oxidative stress is considered to be oneof the major toxicity mechanisms, however, only few amphibianstudies are dealing with detoxification responses besidesstandard parameters. The aim of this study was to estimate theinfluence of widespread environmental pollutant in standardacute test using Xenopus frogs supplemented with themeasurement of biomarkers of oxidative stress. Sublethaleffects on modulation of antioxidative and detoxificationcompounds (glutathione, glutathione-S-transferase, glutathionereductase and peroxidase, catalase, superoxide dismutase andcytochrome P450 as EROD) were observed. Oxidative stressexpressed as the potential lipid and protein dissociation wasdetermined. Lower effect concentrations of biomarkers ofoxidative stress preceding any sign of toxicity were found. Therole of oxidative stress in embryotoxicity and teratogenesiswas examined. Research was supported by the chancellor ofMasaryk University (project 20061431E0014) and INCHEMBIOL0021622412." @default.
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- W2600254958 date "2007-01-01" @default.
- W2600254958 modified "2023-10-17" @default.
- W2600254958 title "Role of oxidative stress in embryotoxicity and teratogenesis inFETAX test" @default.
- W2600254958 hasPublicationYear "2007" @default.
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