FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600289562> ?p ?o ?g. }

• W2600289562 endingPage "4415" @default.
• W2600289562 startingPage "4405" @default.
• W2600289562 abstract "The neuromodulator acetylcholine modulates spatial integration in visual cortex by altering the balance of inputs that generate neuronal receptive fields. These cholinergic effects may provide a neurobiological mechanism underlying the modulation of visual representations by visual spatial attention. However, the consequences of cholinergic enhancement on visuospatial perception in humans are unknown. We conducted two experiments to test whether enhancing cholinergic signaling selectively alters perceptual measures of visuospatial interactions in human subjects. In Experiment 1, a double-blind placebo-controlled pharmacology study, we measured how flanking distractors influenced detection of a small contrast decrement of a peripheral target, as a function of target-flanker distance. We found that cholinergic enhancement with the cholinesterase inhibitor donepezil improved target detection, and modeling suggested that this was mainly due to a narrowing of the extent of facilitatory perceptual spatial interactions. In Experiment 2, we tested whether these effects were selective to the cholinergic system or would also be observed following enhancements of related neuromodulators dopamine or norepinephrine. Unlike cholinergic enhancement, dopamine (bromocriptine) and norepinephrine (guanfacine) manipulations did not improve performance or systematically alter the spatial profile of perceptual interactions between targets and distractors. These findings reveal mechanisms by which cholinergic signaling influences visual spatial interactions in perception and improves processing of a visual target among distractors, effects that are notably similar to those of spatial selective attention. SIGNIFICANCE STATEMENT Acetylcholine influences how visual cortical neurons integrate signals across space, perhaps providing a neurobiological mechanism for the effects of visual selective attention. However, the influence of cholinergic enhancement on visuospatial perception remains unknown. Here we demonstrate that cholinergic enhancement improves detection of a target flanked by distractors, consistent with sharpened visuospatial perceptual representations. Furthermore, whereas most pharmacological studies focus on a single neurotransmitter, many neuromodulators can have related effects on cognition and perception. Thus, we also demonstrate that enhancing noradrenergic and dopaminergic systems does not systematically improve visuospatial perception or alter its tuning. Our results link visuospatial tuning effects of acetylcholine at the neuronal and perceptual levels and provide insights into the connection between cholinergic signaling and visual attention." @default.
• W2600289562 created "2017-04-07" @default.
• W2600289562 creator A5005290023 @default.
• W2600289562 creator A5015933111 @default.
• W2600289562 creator A5046805836 @default.
• W2600289562 creator A5064907191 @default.
• W2600289562 creator A5066098469 @default.
• W2600289562 creator A5071468453 @default.
• W2600289562 date "2017-03-23" @default.
• W2600289562 modified "2023-09-25" @default.
• W2600289562 title "Cholinergic, But Not Dopaminergic or Noradrenergic, Enhancement Sharpens Visual Spatial Perception in Humans" @default.
• W2600289562 cites W1497878968 @default.
• W2600289562 cites W1531855108 @default.
• W2600289562 cites W1971198963 @default.
• W2600289562 cites W1971536386 @default.
• W2600289562 cites W1981256555 @default.
• W2600289562 cites W1982166376 @default.
• W2600289562 cites W1982551220 @default.
• W2600289562 cites W1985193702 @default.
• W2600289562 cites W1987091388 @default.
• W2600289562 cites W1988123869 @default.
• W2600289562 cites W1997377167 @default.
• W2600289562 cites W1998628383 @default.
• W2600289562 cites W2003858598 @default.
• W2600289562 cites W2008123860 @default.
• W2600289562 cites W2008506107 @default.
• W2600289562 cites W2017108196 @default.
• W2600289562 cites W2018726091 @default.
• W2600289562 cites W2019708732 @default.
• W2600289562 cites W2022847469 @default.
• W2600289562 cites W2024391265 @default.
• W2600289562 cites W2026917420 @default.
• W2600289562 cites W2036322060 @default.
• W2600289562 cites W2039998766 @default.
• W2600289562 cites W2042036980 @default.
• W2600289562 cites W2045304420 @default.
• W2600289562 cites W2046835548 @default.
• W2600289562 cites W2048396168 @default.
• W2600289562 cites W2050629291 @default.
• W2600289562 cites W2062092741 @default.
• W2600289562 cites W2063137814 @default.
• W2600289562 cites W2065321563 @default.
• W2600289562 cites W2071693281 @default.
• W2600289562 cites W2072731831 @default.
• W2600289562 cites W2081801816 @default.
• W2600289562 cites W2083323215 @default.
• W2600289562 cites W2084007108 @default.
• W2600289562 cites W2087532149 @default.
• W2600289562 cites W2088853509 @default.
• W2600289562 cites W2089288768 @default.
• W2600289562 cites W2089935186 @default.
• W2600289562 cites W2091255007 @default.
• W2600289562 cites W2091314916 @default.
• W2600289562 cites W2094134651 @default.
• W2600289562 cites W2096253586 @default.
• W2600289562 cites W2103865413 @default.
• W2600289562 cites W2104849082 @default.
• W2600289562 cites W2106246424 @default.
• W2600289562 cites W2110258654 @default.
• W2600289562 cites W2115095583 @default.
• W2600289562 cites W2116799948 @default.
• W2600289562 cites W2119144342 @default.
• W2600289562 cites W2121194451 @default.
• W2600289562 cites W2128549190 @default.
• W2600289562 cites W2130432173 @default.
• W2600289562 cites W2135255280 @default.
• W2600289562 cites W2145979004 @default.
• W2600289562 cites W2149316826 @default.
• W2600289562 cites W2158024903 @default.
• W2600289562 cites W2159621737 @default.
• W2600289562 cites W2160985876 @default.
• W2600289562 cites W2162056177 @default.
• W2600289562 cites W2164549762 @default.
• W2600289562 cites W2164821882 @default.
• W2600289562 cites W2165478949 @default.
• W2600289562 cites W2169246336 @default.
• W2600289562 cites W2767359737 @default.
• W2600289562 cites W4294214781 @default.
• W2600289562 doi "https://doi.org/10.1523/jneurosci.2405-16.2017" @default.
• W2600289562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5413181" @default.
• W2600289562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28336568" @default.
• W2600289562 hasPublicationYear "2017" @default.
• W2600289562 type Work @default.
• W2600289562 sameAs 2600289562 @default.
• W2600289562 citedByCount "48" @default.
• W2600289562 countsByYear W26002895622017 @default.
• W2600289562 countsByYear W26002895622018 @default.
• W2600289562 countsByYear W26002895622019 @default.
• W2600289562 countsByYear W26002895622020 @default.
• W2600289562 countsByYear W26002895622021 @default.
• W2600289562 countsByYear W26002895622022 @default.
• W2600289562 countsByYear W26002895622023 @default.
• W2600289562 crossrefType "journal-article" @default.
• W2600289562 hasAuthorship W2600289562A5005290023 @default.
• W2600289562 hasAuthorship W2600289562A5015933111 @default.
• W2600289562 hasAuthorship W2600289562A5046805836 @default.
• W2600289562 hasAuthorship W2600289562A5064907191 @default.
• W2600289562 hasAuthorship W2600289562A5066098469 @default.

• next