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• W2600339997 abstract "Increased evidence suggests that marine unsaturated fatty acids (FAs) can protect neurons from amyloid-β (Aβ)-induced neurodegeneration. Nuclear magnetic resonance (NMR), high performance liquid chromatography (HPLC) and gas chromatography (GC) assays showed that the acetone extract 4-2A obtained from shrimp Pandalus borealis industry processing wastes contained 67.19% monounsaturated FAs and 16.84% polyunsaturated FAs. The present study evaluated the anti-oxidative and anti-inflammatory effects of 4-2A in Aβ25–35-insulted differentiated SH-SY5Y cells. Cell viability and cytotoxicity were measured by using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays. Quantitative PCR and Western blotting were used to study the expression of neurotrophins, pro-inflammatory cytokines and apoptosis-related genes. Administration of 20 μM Aβ25–35 significantly reduced SH-SY5Y cell viability, the expression of nerve growth factor (NGF) and its tyrosine kinase TrkA receptor, as well as the level of glutathione, while increased reactive oxygen species (ROS), nitric oxide, tumor necrosis factor (TNF)-α, brain derived neurotrophic factor (BDNF) and its TrkB receptor. Aβ25–35 also increased the Bax/Bcl-2 ratio and Caspase-3 expression. Treatment with 4-2A significantly attenuated the Aβ25–35-induced changes in cell viability, ROS, GSH, NGF, TrkA, TNF-α, the Bax/Bcl-2 ratio and Caspase-3, except for nitric oxide, BDNF and TrKB. In conclusion, 4-2A effectively protected SH-SY5Y cells against Aβ-induced neuronal apoptosis/death by suppressing inflammation and oxidative stress and up-regulating NGF and TrKA expression." @default.
• W2600339997 created "2017-04-07" @default.
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• W2600339997 date "2017-03-22" @default.
• W2600339997 modified "2023-10-16" @default.
• W2600339997 title "An Extract from Shrimp Processing By-Products Protects SH-SY5Y Cells from Neurotoxicity Induced by Aβ25–35" @default.
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• W2600339997 cites W16726793 @default.
• W2600339997 cites W1812789667 @default.
• W2600339997 cites W1823755123 @default.
• W2600339997 cites W1841850981 @default.
• W2600339997 cites W1855589073 @default.
• W2600339997 cites W1883938883 @default.
• W2600339997 cites W1900922443 @default.
• W2600339997 cites W1960145271 @default.
• W2600339997 cites W1975998750 @default.
• W2600339997 cites W1983653836 @default.
• W2600339997 cites W1983668432 @default.
• W2600339997 cites W1988360928 @default.
• W2600339997 cites W1998836938 @default.
• W2600339997 cites W2002448380 @default.
• W2600339997 cites W2004027078 @default.
• W2600339997 cites W2004665203 @default.
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• W2600339997 cites W2014208353 @default.
• W2600339997 cites W2015068992 @default.
• W2600339997 cites W2018873429 @default.
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• W2600339997 cites W2026871529 @default.
• W2600339997 cites W2032110442 @default.
• W2600339997 cites W2033375031 @default.
• W2600339997 cites W2044070452 @default.
• W2600339997 cites W2047573957 @default.
• W2600339997 cites W2049771698 @default.
• W2600339997 cites W2050087725 @default.
• W2600339997 cites W2053307994 @default.
• W2600339997 cites W2075183497 @default.
• W2600339997 cites W2081209905 @default.
• W2600339997 cites W2082921087 @default.
• W2600339997 cites W2083043503 @default.
• W2600339997 cites W2084437444 @default.
• W2600339997 cites W2085918895 @default.
• W2600339997 cites W2088940658 @default.
• W2600339997 cites W2090974252 @default.
• W2600339997 cites W2093874807 @default.
• W2600339997 cites W2094544734 @default.
• W2600339997 cites W2094759938 @default.
• W2600339997 cites W2099492526 @default.
• W2600339997 cites W2099904249 @default.
• W2600339997 cites W2102248649 @default.
• W2600339997 cites W2109317493 @default.
• W2600339997 cites W2113000310 @default.
• W2600339997 cites W2115818030 @default.
• W2600339997 cites W2140470674 @default.
• W2600339997 cites W2150239086 @default.
• W2600339997 cites W2157480158 @default.
• W2600339997 cites W2162794208 @default.
• W2600339997 cites W2168364295 @default.
• W2600339997 cites W2207032087 @default.
• W2600339997 cites W2228484853 @default.
• W2600339997 cites W2250288471 @default.
• W2600339997 cites W2277230837 @default.
• W2600339997 cites W2329336071 @default.
• W2600339997 cites W2331778217 @default.
• W2600339997 cites W2342282778 @default.
• W2600339997 cites W2474131202 @default.
• W2600339997 cites W2565031650 @default.
• W2600339997 cites W2571799777 @default.
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• W2600339997 doi "https://doi.org/10.3390/md15030083" @default.
• W2600339997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5367040" @default.
• W2600339997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28327516" @default.
• W2600339997 hasPublicationYear "2017" @default.
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