Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600356273> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2600356273 endingPage "1026" @default.
- W2600356273 startingPage "1022" @default.
- W2600356273 abstract "Abstract Amine transaminase (ATA) catalyzing stereoselective amination of prochiral ketones is an attractive alternative to transition metal catalysis. As wild‐type ATAs do not accept sterically hindered ketones, efforts to widen the substrate scope to more challenging targets are of general interest. We recently designed ATAs to accept aromatic and thus planar bulky amines, with a sequence‐based motif that supports the identification of novel enzymes. However, these variants were not active against 2,2‐dimethyl‐1‐phenyl‐propan‐1‐one, which carries a bulky tert ‐butyl substituent adjacent to the carbonyl function. Here, we report a solution for this type of substrate. The evolved ATAs perform asymmetric synthesis of the respective R amine with high conversions by using either alanine or isopropylamine as amine donor." @default.
- W2600356273 created "2017-04-07" @default.
- W2600356273 creator A5025199906 @default.
- W2600356273 creator A5026049193 @default.
- W2600356273 creator A5031181844 @default.
- W2600356273 creator A5035630705 @default.
- W2600356273 creator A5036660496 @default.
- W2600356273 creator A5057716075 @default.
- W2600356273 creator A5091400511 @default.
- W2600356273 date "2017-04-27" @default.
- W2600356273 modified "2023-10-09" @default.
- W2600356273 title "Amine Transaminase Engineering for Spatially Bulky Substrate Acceptance" @default.
- W2600356273 cites W1926603859 @default.
- W2600356273 cites W1986056153 @default.
- W2600356273 cites W1998899760 @default.
- W2600356273 cites W2006459466 @default.
- W2600356273 cites W2041571635 @default.
- W2600356273 cites W2073373061 @default.
- W2600356273 cites W2107677212 @default.
- W2600356273 cites W2108742112 @default.
- W2600356273 cites W2112306226 @default.
- W2600356273 cites W2153433577 @default.
- W2600356273 cites W2328445540 @default.
- W2600356273 cites W2496645452 @default.
- W2600356273 cites W2518295168 @default.
- W2600356273 cites W2528127298 @default.
- W2600356273 cites W2528204036 @default.
- W2600356273 doi "https://doi.org/10.1002/cbic.201700033" @default.
- W2600356273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28334484" @default.
- W2600356273 hasPublicationYear "2017" @default.
- W2600356273 type Work @default.
- W2600356273 sameAs 2600356273 @default.
- W2600356273 citedByCount "40" @default.
- W2600356273 countsByYear W26003562732017 @default.
- W2600356273 countsByYear W26003562732018 @default.
- W2600356273 countsByYear W26003562732019 @default.
- W2600356273 countsByYear W26003562732020 @default.
- W2600356273 countsByYear W26003562732021 @default.
- W2600356273 countsByYear W26003562732022 @default.
- W2600356273 countsByYear W26003562732023 @default.
- W2600356273 crossrefType "journal-article" @default.
- W2600356273 hasAuthorship W2600356273A5025199906 @default.
- W2600356273 hasAuthorship W2600356273A5026049193 @default.
- W2600356273 hasAuthorship W2600356273A5031181844 @default.
- W2600356273 hasAuthorship W2600356273A5035630705 @default.
- W2600356273 hasAuthorship W2600356273A5036660496 @default.
- W2600356273 hasAuthorship W2600356273A5057716075 @default.
- W2600356273 hasAuthorship W2600356273A5091400511 @default.
- W2600356273 hasConcept C111368507 @default.
- W2600356273 hasConcept C127313418 @default.
- W2600356273 hasConcept C131779359 @default.
- W2600356273 hasConcept C161790260 @default.
- W2600356273 hasConcept C178790620 @default.
- W2600356273 hasConcept C181647583 @default.
- W2600356273 hasConcept C185592680 @default.
- W2600356273 hasConcept C198503264 @default.
- W2600356273 hasConcept C201194858 @default.
- W2600356273 hasConcept C21951064 @default.
- W2600356273 hasConcept C2777289219 @default.
- W2600356273 hasConcept C2778689049 @default.
- W2600356273 hasConcept C2781206959 @default.
- W2600356273 hasConcept C71240020 @default.
- W2600356273 hasConceptScore W2600356273C111368507 @default.
- W2600356273 hasConceptScore W2600356273C127313418 @default.
- W2600356273 hasConceptScore W2600356273C131779359 @default.
- W2600356273 hasConceptScore W2600356273C161790260 @default.
- W2600356273 hasConceptScore W2600356273C178790620 @default.
- W2600356273 hasConceptScore W2600356273C181647583 @default.
- W2600356273 hasConceptScore W2600356273C185592680 @default.
- W2600356273 hasConceptScore W2600356273C198503264 @default.
- W2600356273 hasConceptScore W2600356273C201194858 @default.
- W2600356273 hasConceptScore W2600356273C21951064 @default.
- W2600356273 hasConceptScore W2600356273C2777289219 @default.
- W2600356273 hasConceptScore W2600356273C2778689049 @default.
- W2600356273 hasConceptScore W2600356273C2781206959 @default.
- W2600356273 hasConceptScore W2600356273C71240020 @default.
- W2600356273 hasIssue "11" @default.
- W2600356273 hasLocation W26003562731 @default.
- W2600356273 hasLocation W26003562732 @default.
- W2600356273 hasOpenAccess W2600356273 @default.
- W2600356273 hasPrimaryLocation W26003562731 @default.
- W2600356273 hasRelatedWork W1597518231 @default.
- W2600356273 hasRelatedWork W1975920026 @default.
- W2600356273 hasRelatedWork W1982379994 @default.
- W2600356273 hasRelatedWork W1984630625 @default.
- W2600356273 hasRelatedWork W2019780159 @default.
- W2600356273 hasRelatedWork W2048416638 @default.
- W2600356273 hasRelatedWork W2063700760 @default.
- W2600356273 hasRelatedWork W2371045761 @default.
- W2600356273 hasRelatedWork W2951800301 @default.
- W2600356273 hasRelatedWork W2981286922 @default.
- W2600356273 hasVolume "18" @default.
- W2600356273 isParatext "false" @default.
- W2600356273 isRetracted "false" @default.
- W2600356273 magId "2600356273" @default.
- W2600356273 workType "article" @default.