FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600386851> ?p ?o ?g. }

• W2600386851 abstract "Abstract Increasing evidence suggests thrombospondin-1 (TSP-1), a potent proatherogenic matricellular protein, as a putative link between hyperglycemia and atherosclerotic complications in diabetes. We previously reported that the micronutrient chromium picolinate (CrP), with long-standing cardiovascular benefits, inhibits TSP-1 expression in glucose-stimulated human aortic smooth muscle cells in vitro . Here, we investigated the atheroprotective action of orally administered CrP in type 1 diabetic apolipoprotein E-deficient (ApoE −/− ) mice and elucidated the role of TSP-1 in this process. CrP decreased lipid burden and neointimal thickness in aortic root lesions of hyperglycemic ApoE −/− mice; also, smooth muscle cell (SMC), macrophage and leukocyte abundance was prevented coupled with reduced cell proliferation. Attenuated lesion progression was accompanied with inhibition of hyperglycemia-induced TSP-1 expression and reduced protein O-glycosylation following CrP treatment; also, PCNA and vimentin (SMC synthetic marker) expression were reduced while SM-MHC (SMC contractile marker) levels were increased. To confirm a direct role of TSP-1 in diabetic atherosclerosis, hyperglycemic TSP-1 −/− /ApoE −/− double knockout mice were compared with age-matched hyperglycemic ApoE −/− littermates. Lack of TSP-1 prevented lesion formation in hyperglycemic ApoE −/− mice, mimicking the atheroprotective phenotype of CrP-treated mice. These results suggest that therapeutic TSP-1 inhibition may have important atheroprotective potential in diabetic vascular disease." @default.
• W2600386851 created "2017-04-07" @default.
• W2600386851 creator A5009593270 @default.
• W2600386851 creator A5021585479 @default.
• W2600386851 creator A5028544689 @default.
• W2600386851 creator A5039778000 @default.
• W2600386851 creator A5049054442 @default.
• W2600386851 creator A5055758836 @default.
• W2600386851 creator A5072041574 @default.
• W2600386851 creator A5079600986 @default.
• W2600386851 date "2017-03-27" @default.
• W2600386851 modified "2023-09-26" @default.
• W2600386851 title "Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE−/− mice" @default.
• W2600386851 cites W151966373 @default.
• W2600386851 cites W1560698173 @default.
• W2600386851 cites W1605462184 @default.
• W2600386851 cites W1667957779 @default.
• W2600386851 cites W1752045965 @default.
• W2600386851 cites W1880042570 @default.
• W2600386851 cites W1949072443 @default.
• W2600386851 cites W1965602767 @default.
• W2600386851 cites W1967773283 @default.
• W2600386851 cites W1970845955 @default.
• W2600386851 cites W1972477461 @default.
• W2600386851 cites W1973042928 @default.
• W2600386851 cites W1983188535 @default.
• W2600386851 cites W1985634174 @default.
• W2600386851 cites W1987580419 @default.
• W2600386851 cites W1994806443 @default.
• W2600386851 cites W1995464415 @default.
• W2600386851 cites W1995621485 @default.
• W2600386851 cites W2001186057 @default.
• W2600386851 cites W2008831099 @default.
• W2600386851 cites W2015629585 @default.
• W2600386851 cites W2018725029 @default.
• W2600386851 cites W2025531808 @default.
• W2600386851 cites W2042933787 @default.
• W2600386851 cites W2052326460 @default.
• W2600386851 cites W2064640260 @default.
• W2600386851 cites W2066143342 @default.
• W2600386851 cites W2081471836 @default.
• W2600386851 cites W2089896222 @default.
• W2600386851 cites W2092208645 @default.
• W2600386851 cites W2093176315 @default.
• W2600386851 cites W2097433480 @default.
• W2600386851 cites W2102786937 @default.
• W2600386851 cites W2104118305 @default.
• W2600386851 cites W2110962531 @default.
• W2600386851 cites W2118134687 @default.
• W2600386851 cites W2120007090 @default.
• W2600386851 cites W2122360768 @default.
• W2600386851 cites W2124814311 @default.
• W2600386851 cites W2129033842 @default.
• W2600386851 cites W2132092963 @default.
• W2600386851 cites W2134912211 @default.
• W2600386851 cites W2135283951 @default.
• W2600386851 cites W2138043196 @default.
• W2600386851 cites W2140304913 @default.
• W2600386851 cites W2145114717 @default.
• W2600386851 cites W2147087645 @default.
• W2600386851 cites W2162788755 @default.
• W2600386851 cites W2164288846 @default.
• W2600386851 cites W2165256339 @default.
• W2600386851 cites W2167247223 @default.
• W2600386851 cites W2167810162 @default.
• W2600386851 cites W2181792468 @default.
• W2600386851 cites W2224048551 @default.
• W2600386851 cites W2396173285 @default.
• W2600386851 cites W2429892406 @default.
• W2600386851 doi "https://doi.org/10.1038/srep45279" @default.
• W2600386851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5366888" @default.
• W2600386851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28345659" @default.
• W2600386851 hasPublicationYear "2017" @default.
• W2600386851 type Work @default.
• W2600386851 sameAs 2600386851 @default.
• W2600386851 citedByCount "22" @default.
• W2600386851 countsByYear W26003868512018 @default.
• W2600386851 countsByYear W26003868512020 @default.
• W2600386851 countsByYear W26003868512021 @default.
• W2600386851 countsByYear W26003868512022 @default.
• W2600386851 countsByYear W26003868512023 @default.
• W2600386851 crossrefType "journal-article" @default.
• W2600386851 hasAuthorship W2600386851A5009593270 @default.
• W2600386851 hasAuthorship W2600386851A5021585479 @default.
• W2600386851 hasAuthorship W2600386851A5028544689 @default.
• W2600386851 hasAuthorship W2600386851A5039778000 @default.
• W2600386851 hasAuthorship W2600386851A5049054442 @default.
• W2600386851 hasAuthorship W2600386851A5055758836 @default.
• W2600386851 hasAuthorship W2600386851A5072041574 @default.
• W2600386851 hasAuthorship W2600386851A5079600986 @default.
• W2600386851 hasBestOaLocation W26003868511 @default.
• W2600386851 hasConcept C126322002 @default.
• W2600386851 hasConcept C134018914 @default.
• W2600386851 hasConcept C185592680 @default.
• W2600386851 hasConcept C189165786 @default.
• W2600386851 hasConcept C2775893135 @default.
• W2600386851 hasConcept C2778163477 @default.
• W2600386851 hasConcept C2779134260 @default.
• W2600386851 hasConcept C2779395532 @default.
• W2600386851 hasConcept C2992686903 @default.

• next