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- W2600394416 abstract "Background: Malaria is a preventable and treatable infectious disease; however, malaria is extremely common in many parts of the world. Hearing loss can be devastating and adversely affect individuals and populations. Malaria and antimalarial regimens may affect hearing, thus causing significant functional, social, and developmental issues. This article explores the link between hearing loss and malaria, and ototoxicity from antimalarial chemotherapy. Aim: The aim of this study was to perform a systematic literature review on hearing loss in malaria. Design: A systematic search of the literature and a discussion of the results. Method: A search was performed in MEDLINE via OvidSP, Scopus, and PubMed databases. Results: Of 13 papers analysed, one was a systematic review on the direct effect of malaria on hearing loss, which suggested that malaria may directly cause hearing loss through biological processes not well understood. No prospective studies on this issue have been done to date. Collectively, reports have shown minimal evidence that antimalarial medications cause ototoxicity, except for quinine, which is well recognised as an ototoxic agent. Conclusion: This study highlights evidence that malaria may cause hearing impairment. Although there is limited definitive evidence, the impact malaria may have on altering hearing thresholds is increasingly recognised. Most antimalarial medications are safe for the ear. Quinine produces a predictable, but reversible, hearing loss. More research should aim to identify whether a direct link exists between malaria and hearing loss because malaria is a global burden, the impact of hearing loss can be substantial, and studies evaluating drug toxicity may be confounded by deafness due to malaria itself." @default.
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- W2600394416 date "2015-03-01" @default.
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- W2600394416 title "Hearing loss in malaria" @default.
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