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- W2600403059 abstract "核糖体是由核糖体RNA和核糖体蛋白组成的复合体, 其功能是参与蛋白质合成. SUMO化修饰的底物蛋白对核糖体的形成有重要调控作用. 前期研究发现, KRAB型锌指蛋白Apak能特异地抑制p53所介导的凋亡通路. 进一步研究发现, 在核仁应激及癌基因激活条件下, 抑癌蛋白ARF促进Apak发生SUMO化修饰并促使其移位于核仁. 为了进一步探讨SUMO化修饰的Apak对核糖体RNA合成的调控功能, 本研究通过Northern blot检测SUMO化修饰的Apak对核糖体RNA合成的影响, 实时定量PCR检测核糖体RNA转录水平, RNA-ChIP方法检测核糖体RNA与Apak蛋白的相互作用, 结果表明, SUMO化修饰的Apak抑制47S核糖体RNA前体的合成且抑制RNA聚合酶Ⅰ介导转录的18S和5.8S rRNA的合成; 在放线菌素D以及癌基因诱导下, 促进Apak与18S, 5.8S rRNA相互作用. 本研究对理解Apak的功能和作用机制提供了新的依据, 为深入研究KRAB型锌指蛋白家族分子对核糖体RNA的调控奠定了基础." @default.
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- W2600403059 date "2015-11-01" @default.
- W2600403059 modified "2023-09-24" @default.
- W2600403059 title "SUMOylation of Apak Regulates Ribosome RNA Synthesis" @default.
- W2600403059 doi "https://doi.org/10.1360/n052015-00064" @default.
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