FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600432485> ?p ?o ?g. }

• W2600432485 endingPage "e1006286" @default.
• W2600432485 startingPage "e1006286" @default.
• W2600432485 abstract "Coronavirus replication takes place in the host cell cytoplasm and triggers inflammatory gene expression by poorly characterized mechanisms. To obtain more insight into the signals and molecular events that coordinate global host responses in the nucleus of coronavirus-infected cells, first, transcriptome dynamics was studied in human coronavirus 229E (HCoV-229E)-infected A549 and HuH7 cells, respectively, revealing a core signature of upregulated genes in these cells. Compared to treatment with the prototypical inflammatory cytokine interleukin(IL)-1, HCoV-229E replication was found to attenuate the inducible activity of the transcription factor (TF) NF-κB and to restrict the nuclear concentration of NF-κB subunits by (i) an unusual mechanism involving partial degradation of IKKβ, NEMO and IκBα and (ii) upregulation of TNFAIP3 (A20), although constitutive IKK activity and basal TNFAIP3 expression levels were shown to be required for efficient virus replication. Second, we characterized actively transcribed genomic regions and enhancers in HCoV-229E-infected cells and systematically correlated the genome-wide gene expression changes with the recruitment of Ser5-phosphorylated RNA polymerase II and prototypical histone modifications (H3K9ac, H3K36ac, H4K5ac, H3K27ac, H3K4me1). The data revealed that, in HCoV-infected (but not IL-1-treated) cells, an extensive set of genes was activated without inducible p65 NF-κB being recruited. Furthermore, both HCoV-229E replication and IL-1 were shown to upregulate a small set of genes encoding immunomodulatory factors that bind p65 at promoters and require IKKβ activity and p65 for expression. Also, HCoV-229E and IL-1 activated a common set of 440 p65-bound enhancers that differed from another 992 HCoV-229E-specific enhancer regions by distinct TF-binding motif combinations. Taken together, the study shows that cytoplasmic RNA viruses fine-tune NF-κB signaling at multiple levels and profoundly reprogram the host cellular chromatin landscape, thereby orchestrating the timely coordinated expression of genes involved in multiple signaling, immunoregulatory and metabolic processes." @default.
• W2600432485 created "2017-04-07" @default.
• W2600432485 creator A5006716895 @default.
• W2600432485 creator A5012136239 @default.
• W2600432485 creator A5020892711 @default.
• W2600432485 creator A5025630166 @default.
• W2600432485 creator A5037220101 @default.
• W2600432485 creator A5038809023 @default.
• W2600432485 creator A5039470820 @default.
• W2600432485 creator A5039833715 @default.
• W2600432485 creator A5062131165 @default.
• W2600432485 creator A5069332888 @default.
• W2600432485 creator A5079091527 @default.
• W2600432485 creator A5088771461 @default.
• W2600432485 date "2017-03-29" @default.
• W2600432485 modified "2023-10-01" @default.
• W2600432485 title "The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells" @default.
• W2600432485 cites W1490370778 @default.
• W2600432485 cites W1569833788 @default.
• W2600432485 cites W165388538 @default.
• W2600432485 cites W1686821153 @default.
• W2600432485 cites W1963611256 @default.
• W2600432485 cites W1965191873 @default.
• W2600432485 cites W1969699638 @default.
• W2600432485 cites W1980195461 @default.
• W2600432485 cites W1984064716 @default.
• W2600432485 cites W1986586739 @default.
• W2600432485 cites W1998392642 @default.
• W2600432485 cites W2001975441 @default.
• W2600432485 cites W2003406586 @default.
• W2600432485 cites W2014487118 @default.
• W2600432485 cites W2016015848 @default.
• W2600432485 cites W2016098919 @default.
• W2600432485 cites W2016921919 @default.
• W2600432485 cites W2019070913 @default.
• W2600432485 cites W2019312368 @default.
• W2600432485 cites W2021662182 @default.
• W2600432485 cites W2022218113 @default.
• W2600432485 cites W2024791006 @default.
• W2600432485 cites W2025697001 @default.
• W2600432485 cites W2031437584 @default.
• W2600432485 cites W2032538322 @default.
• W2600432485 cites W2034001730 @default.
• W2600432485 cites W2039689649 @default.
• W2600432485 cites W2042073539 @default.
• W2600432485 cites W2044446306 @default.
• W2600432485 cites W2045362835 @default.
• W2600432485 cites W2047562490 @default.
• W2600432485 cites W2052908553 @default.
• W2600432485 cites W2061786382 @default.
• W2600432485 cites W2062817591 @default.
• W2600432485 cites W2063338364 @default.
• W2600432485 cites W2063815548 @default.
• W2600432485 cites W2065360219 @default.
• W2600432485 cites W2074471441 @default.
• W2600432485 cites W2076174368 @default.
• W2600432485 cites W2077021609 @default.
• W2600432485 cites W2077165618 @default.
• W2600432485 cites W2080804122 @default.
• W2600432485 cites W2083245183 @default.
• W2600432485 cites W2092969802 @default.
• W2600432485 cites W2094875270 @default.
• W2600432485 cites W2096083625 @default.
• W2600432485 cites W2101198806 @default.
• W2600432485 cites W2105195950 @default.
• W2600432485 cites W2106077567 @default.
• W2600432485 cites W2108624061 @default.
• W2600432485 cites W2111897512 @default.
• W2600432485 cites W2115218339 @default.
• W2600432485 cites W2117117846 @default.
• W2600432485 cites W2118483041 @default.
• W2600432485 cites W2125605037 @default.
• W2600432485 cites W2151451117 @default.
• W2600432485 cites W2156639337 @default.
• W2600432485 cites W2161983082 @default.
• W2600432485 cites W2165947392 @default.
• W2600432485 cites W2177908652 @default.
• W2600432485 cites W2199062374 @default.
• W2600432485 cites W2263936114 @default.
• W2600432485 cites W2342335701 @default.
• W2600432485 cites W2482555465 @default.
• W2600432485 cites W2737785069 @default.
• W2600432485 cites W4244307272 @default.
• W2600432485 doi "https://doi.org/10.1371/journal.ppat.1006286" @default.
• W2600432485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5386326" @default.
• W2600432485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28355270" @default.
• W2600432485 hasPublicationYear "2017" @default.
• W2600432485 type Work @default.
• W2600432485 sameAs 2600432485 @default.
• W2600432485 citedByCount "81" @default.
• W2600432485 countsByYear W26004324852017 @default.
• W2600432485 countsByYear W26004324852018 @default.
• W2600432485 countsByYear W26004324852019 @default.
• W2600432485 countsByYear W26004324852020 @default.
• W2600432485 countsByYear W26004324852021 @default.
• W2600432485 countsByYear W26004324852022 @default.
• W2600432485 countsByYear W26004324852023 @default.
• W2600432485 crossrefType "journal-article" @default.

• next