Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600432810> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2600432810 abstract "Background and objective: Chamomile has been used as an herbal medication sinceancient times and is still popular until today. This study aimed to investigate the potentialanticytotoxic effect of chamomile extract on the lingual mucosa of rabbits treated with5-fluorouracil (5-FU).Methods: Thirty six rabbits were used in the study. For induction of tongue mucositis forthe study group, 5-FU at a dose of (4 mg/kg) was administered intraperitoneally one timedaily for five successive days. The control animals were intraperitoneally injected bynormal saline one time daily for five successive days. The rats in each group wererandomly divided into two groups: Distilled water and chamomile extract treated groups(9 animals each). A volume of distilled water equal to chamomile extract was given bygavage tube, while the other group was gavaged with chamomile extract at a dose of (100mg/ kg) one time daily. The treatment with distilled water or the chamomile extract wascontinued for sixteen days and then the animals were sacrificed, and the tongues wereexcised for histopathological and immunohistochemical analysis.Results: The 5-FU/water treated group showed a significant increase in histologicaldamage scores, decrease in the ki-67and increase in caspase -3 epithelial immuneexpression (P <0.05) in comparison with saline/water treated group. The 5-FU/chamomiletreated group showed a significant increase in damage score, significant decrease in ki-67immune expression and significant increase in caspase-3 immune expression (P <0.05) incomparison with 5-FU/water treated group.Conclusion: Chamomile extract at a dose of (100 mg/ kg) one time daily for sixteen dayscannot be used for the treatment of oral mucositis. It causes damage to the tissue,decreases proliferation, and increases apoptosis." @default.
- W2600432810 created "2017-04-07" @default.
- W2600432810 creator A5007761777 @default.
- W2600432810 creator A5026972862 @default.
- W2600432810 creator A5054738478 @default.
- W2600432810 date "2017-04-02" @default.
- W2600432810 modified "2023-09-26" @default.
- W2600432810 title "Evaluation of the effect of chamomile extract on lingual histological changes in rabbit received 5-fluorouracil (histological and immunohistochemical study)" @default.
- W2600432810 doi "https://doi.org/10.15218/zjms.2017.003" @default.
- W2600432810 hasPublicationYear "2017" @default.
- W2600432810 type Work @default.
- W2600432810 sameAs 2600432810 @default.
- W2600432810 citedByCount "1" @default.
- W2600432810 countsByYear W26004328102020 @default.
- W2600432810 crossrefType "journal-article" @default.
- W2600432810 hasAuthorship W2600432810A5007761777 @default.
- W2600432810 hasAuthorship W2600432810A5026972862 @default.
- W2600432810 hasAuthorship W2600432810A5054738478 @default.
- W2600432810 hasBestOaLocation W26004328101 @default.
- W2600432810 hasConcept C126322002 @default.
- W2600432810 hasConcept C142724271 @default.
- W2600432810 hasConcept C185592680 @default.
- W2600432810 hasConcept C204232928 @default.
- W2600432810 hasConcept C2777397205 @default.
- W2600432810 hasConcept C2778496288 @default.
- W2600432810 hasConcept C2779429693 @default.
- W2600432810 hasConcept C2779744641 @default.
- W2600432810 hasConcept C29730261 @default.
- W2600432810 hasConcept C43617362 @default.
- W2600432810 hasConcept C71924100 @default.
- W2600432810 hasConceptScore W2600432810C126322002 @default.
- W2600432810 hasConceptScore W2600432810C142724271 @default.
- W2600432810 hasConceptScore W2600432810C185592680 @default.
- W2600432810 hasConceptScore W2600432810C204232928 @default.
- W2600432810 hasConceptScore W2600432810C2777397205 @default.
- W2600432810 hasConceptScore W2600432810C2778496288 @default.
- W2600432810 hasConceptScore W2600432810C2779429693 @default.
- W2600432810 hasConceptScore W2600432810C2779744641 @default.
- W2600432810 hasConceptScore W2600432810C29730261 @default.
- W2600432810 hasConceptScore W2600432810C43617362 @default.
- W2600432810 hasConceptScore W2600432810C71924100 @default.
- W2600432810 hasLocation W26004328101 @default.
- W2600432810 hasOpenAccess W2600432810 @default.
- W2600432810 hasPrimaryLocation W26004328101 @default.
- W2600432810 hasRelatedWork W116271805 @default.
- W2600432810 hasRelatedWork W1964946101 @default.
- W2600432810 hasRelatedWork W1971764830 @default.
- W2600432810 hasRelatedWork W2126372167 @default.
- W2600432810 hasRelatedWork W2181709408 @default.
- W2600432810 hasRelatedWork W2188714233 @default.
- W2600432810 hasRelatedWork W2188911552 @default.
- W2600432810 hasRelatedWork W2337389862 @default.
- W2600432810 hasRelatedWork W2378673704 @default.
- W2600432810 hasRelatedWork W2381261063 @default.
- W2600432810 hasRelatedWork W2383063266 @default.
- W2600432810 hasRelatedWork W2539966552 @default.
- W2600432810 hasRelatedWork W2590980031 @default.
- W2600432810 hasRelatedWork W2833369185 @default.
- W2600432810 hasRelatedWork W2966315516 @default.
- W2600432810 hasRelatedWork W3042320532 @default.
- W2600432810 hasRelatedWork W3881257 @default.
- W2600432810 hasRelatedWork W93738439 @default.
- W2600432810 hasRelatedWork W2182299615 @default.
- W2600432810 hasRelatedWork W2599412686 @default.
- W2600432810 isParatext "false" @default.
- W2600432810 isRetracted "false" @default.
- W2600432810 magId "2600432810" @default.
- W2600432810 workType "article" @default.