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- W2600449726 abstract "e20537 Background: The primary objective of this ancillary study is to longitudinally compare QoL. Secondary objective was to explore definitions of time until definitive deterioration (TUDD) of QoL scores according to minimal clinically important difference cut off (MCID). Methods: Inclusion criteria were age > 18 years, diagnosis of HCC with CLIP 0 - 3 and to be ineligible for curative treatments. Patients (pts) were randomized 1:1 to receive octreotide (30 mg, every 4 weeks for 2 years or until death) or placebo (2 mL NaCl). QoL was evaluated using EORTC QLQ-C30 every 4 weeks up to 24 months. We focused analyses on the following scores: Global Health (GH), Mental Health (EF), Physical Health (PF) and Pain (P). Firstly mean differences of QoL scores between last available measurement and inclusion were compared using Wilcoxon test. Secondly TUDD were estimated using Kaplan Meier, and compared using log-rank tests. They were defined as the time interval between randomization and the first occurrence of a..." @default.
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- W2600449726 date "2009-01-01" @default.
- W2600449726 modified "2023-10-16" @default.
- W2600449726 title "LONGITUDINAL ANALYSIS OF THE QUALITY OF LIFE (QOL) WITHIN A RANDOMIZED PHASE III TRIAL: OCTREOTIDE VERSUS PLACEBO FOR THE PATIENTS HAVING ADVANCED HEPATO-CELLULAR CARCINOMA (HCC)" @default.
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