FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600483921> ?p ?o ?g. }

• W2600483921 endingPage "564" @default.
• W2600483921 startingPage "552" @default.
• W2600483921 abstract "The aim of the study was to give recommendations on patient selection criteria for the administration of boost doses after whole-breast irradiation (WBI) in invasive breast cancer based on available clinical evidence complemented by expert opinion.A systematic search of the PubMed database was conducted to identify factors associated with increased risk for local failure that can define risk groups, and to provide evidence for an adequate guidance to the use of the boost as a function of the risk of local recurrence in breast-conserving therapy. The authors reviewed the published clinical evidence for the use of boost after WBI, complemented by other relevant studies and, through a series of formal meetings communications, formulated the recommendations presented in this article.The GEC-ESTRO Breast Cancer Working Group recommends three categories guiding patient selection for the use of a boost after WBI: (1) a low-risk group for whom boost adds little benefit, including patients aging at least 50 years with unicentric, unifocal, and clear surgical margins of at least 2 mm and no axillary lymph nodes invasion. In this group, a boost of 10-16 Gy EQD2 after WBI (25fr × 2 Gy or 15 fr × 2.67 Gy) is optional and not mandatory, (2) a high-risk group, for whom boost is considered mandatory and where dose escalation above 16 Gy EQD2 should be considered; including patients aging ≤40 years with close margins, extensive intraductal component or triple-negative phenotype, or patients with positive resection margins regardless of patient age, and (3) an intermediate-risk group, for whom the boost (10-16 Gy EQD2) is considered mandatory, includes patients below 40 years without major risk criteria, patients >40 years and <50 years regardless of any risk factors, or patients >50 years with any risk factor (close margins, tumor size >3 cm, extensive intraductal component, lymphovascular invasion, lymph node invasion, multicentric or multifocal tumors, triple-negative phenotype, or after neoadjuvant chemotherapy in case of residual tumor).These recommendations may provide a clinical guidance regarding the use of boost after WBI in invasive breast cancer and holds for standard and hypofractionated WBI. Furthermore they should promote further clinical research focusing on controversial issues in the treatment of early-stage breast carcinoma." @default.
• W2600483921 created "2017-04-07" @default.
• W2600483921 creator A5005749193 @default.
• W2600483921 creator A5013911533 @default.
• W2600483921 creator A5022658116 @default.
• W2600483921 creator A5055656107 @default.
• W2600483921 creator A5065793543 @default.
• W2600483921 creator A5069844351 @default.
• W2600483921 creator A5075780182 @default.
• W2600483921 creator A5084655173 @default.
• W2600483921 date "2017-05-01" @default.
• W2600483921 modified "2023-09-27" @default.
• W2600483921 title "Risk factors and state-of-the-art indications for boost irradiation in invasive breast carcinoma" @default.
• W2600483921 cites W1558469067 @default.
• W2600483921 cites W1588975373 @default.
• W2600483921 cites W1748731440 @default.
• W2600483921 cites W1757030565 @default.
• W2600483921 cites W1787821550 @default.
• W2600483921 cites W1950764026 @default.
• W2600483921 cites W1955989670 @default.
• W2600483921 cites W1971173102 @default.
• W2600483921 cites W1975027202 @default.
• W2600483921 cites W1977942376 @default.
• W2600483921 cites W1978631002 @default.
• W2600483921 cites W1981325985 @default.
• W2600483921 cites W1981477294 @default.
• W2600483921 cites W1981933096 @default.
• W2600483921 cites W1981997865 @default.
• W2600483921 cites W1986041276 @default.
• W2600483921 cites W1986666594 @default.
• W2600483921 cites W1994889452 @default.
• W2600483921 cites W1999496015 @default.
• W2600483921 cites W2000685912 @default.
• W2600483921 cites W2004394141 @default.
• W2600483921 cites W2004986148 @default.
• W2600483921 cites W2010160075 @default.
• W2600483921 cites W2011228946 @default.
• W2600483921 cites W2013690864 @default.
• W2600483921 cites W2014610200 @default.
• W2600483921 cites W2018202466 @default.
• W2600483921 cites W2022482737 @default.
• W2600483921 cites W2022855841 @default.
• W2600483921 cites W2025046931 @default.
• W2600483921 cites W2025491697 @default.
• W2600483921 cites W2025615201 @default.
• W2600483921 cites W2026745527 @default.
• W2600483921 cites W2027276888 @default.
• W2600483921 cites W2033034006 @default.
• W2600483921 cites W2033170772 @default.
• W2600483921 cites W2033176966 @default.
• W2600483921 cites W2035318542 @default.
• W2600483921 cites W2036871048 @default.
• W2600483921 cites W2037089958 @default.
• W2600483921 cites W2039716465 @default.
• W2600483921 cites W2042620601 @default.
• W2600483921 cites W2042644862 @default.
• W2600483921 cites W2055713660 @default.
• W2600483921 cites W2055938077 @default.
• W2600483921 cites W2056175071 @default.
• W2600483921 cites W2058033719 @default.
• W2600483921 cites W2063327753 @default.
• W2600483921 cites W2065020864 @default.
• W2600483921 cites W2065864189 @default.
• W2600483921 cites W2066920146 @default.
• W2600483921 cites W2067420088 @default.
• W2600483921 cites W2068426062 @default.
• W2600483921 cites W2069742036 @default.
• W2600483921 cites W2070665331 @default.
• W2600483921 cites W2072200510 @default.
• W2600483921 cites W2073611256 @default.
• W2600483921 cites W2075153856 @default.
• W2600483921 cites W2075235316 @default.
• W2600483921 cites W2078344316 @default.
• W2600483921 cites W2078602777 @default.
• W2600483921 cites W2079195085 @default.
• W2600483921 cites W2083825568 @default.
• W2600483921 cites W2084086015 @default.
• W2600483921 cites W2084364790 @default.
• W2600483921 cites W2085293995 @default.
• W2600483921 cites W2087934692 @default.
• W2600483921 cites W2088434397 @default.
• W2600483921 cites W2089217498 @default.
• W2600483921 cites W2092882833 @default.
• W2600483921 cites W2095349827 @default.
• W2600483921 cites W2096027508 @default.
• W2600483921 cites W2100025800 @default.
• W2600483921 cites W2100609895 @default.
• W2600483921 cites W2103575328 @default.
• W2600483921 cites W2103740220 @default.
• W2600483921 cites W2104199435 @default.
• W2600483921 cites W2105251884 @default.
• W2600483921 cites W2105759313 @default.
• W2600483921 cites W2106514802 @default.
• W2600483921 cites W2108318793 @default.
• W2600483921 cites W2108385373 @default.
• W2600483921 cites W2109975677 @default.
• W2600483921 cites W2110060834 @default.
• W2600483921 cites W2119975486 @default.

• next