Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600508787> ?p ?o ?g. }
- W2600508787 abstract "Abstract Neonatal brain is particularly vulnerable to pathological levels of bilirubin which elevates and overloads intracellular Ca 2+ , leading to neurotoxicity. However, how voltage-gated calcium channels (VGCCs) are functionally involved in excess calcium influx remains unknown. By performing voltage-clamp recordings from bushy cells in the ventral cochlear nucleus (VCN) in postnatal rat pups (P4-17), we found the total calcium current density was more than doubled over P4-17, but the relative weight of VGCC subtypes changed dramatically, being relatively equal among T, L, N, P/Q and R-type at P4-6 to predominantly L, N, R over T and P/Q at P15-17. Surprisingly, acute administration of bilirubin augmented the VGCC currents specifically mediated by high voltage-activated (HVA) P/Q-type calcium currents. This augment was attenuated by intracellular loading of Ca 2+ buffer EGTA or calmodulin inhibitory peptide. Our findings indicate that acute exposure to bilirubin increases VGCC currents, primarily by targeting P/Q-type calcium channels via Ca 2+ and calmodulin dependent mechanisms to overwhelm neurons with excessive Ca 2+ . Since P/Q-subtype calcium channels are more prominent in neonatal neurons (e.g. P4-6) than later stages, we suggest this subtype-specific enhancement of P/Q-type Ca 2+ currents likely contributes to the early neuronal vulnerability to hyperbilirubinemia in auditory and other brain regions." @default.
- W2600508787 created "2017-04-07" @default.
- W2600508787 creator A5013161918 @default.
- W2600508787 creator A5018331471 @default.
- W2600508787 creator A5022710308 @default.
- W2600508787 creator A5024538101 @default.
- W2600508787 creator A5028426421 @default.
- W2600508787 creator A5039541195 @default.
- W2600508787 creator A5056788729 @default.
- W2600508787 creator A5065062425 @default.
- W2600508787 creator A5070933103 @default.
- W2600508787 creator A5072835444 @default.
- W2600508787 date "2017-03-27" @default.
- W2600508787 modified "2023-09-23" @default.
- W2600508787 title "Bilirubin augments Ca2+ load of developing bushy neurons by targeting specific subtype of voltage-gated calcium channels" @default.
- W2600508787 cites W140535427 @default.
- W2600508787 cites W1488629111 @default.
- W2600508787 cites W1491900501 @default.
- W2600508787 cites W1538179530 @default.
- W2600508787 cites W1576320731 @default.
- W2600508787 cites W1607531254 @default.
- W2600508787 cites W1670142742 @default.
- W2600508787 cites W1673091991 @default.
- W2600508787 cites W1750331652 @default.
- W2600508787 cites W1764484095 @default.
- W2600508787 cites W1778293074 @default.
- W2600508787 cites W1918614609 @default.
- W2600508787 cites W1935095948 @default.
- W2600508787 cites W1955716838 @default.
- W2600508787 cites W1966548950 @default.
- W2600508787 cites W1974813892 @default.
- W2600508787 cites W1977742032 @default.
- W2600508787 cites W1980243386 @default.
- W2600508787 cites W1981646620 @default.
- W2600508787 cites W1984956084 @default.
- W2600508787 cites W2001002126 @default.
- W2600508787 cites W2001256414 @default.
- W2600508787 cites W2005770212 @default.
- W2600508787 cites W2007489401 @default.
- W2600508787 cites W2007804932 @default.
- W2600508787 cites W2009512214 @default.
- W2600508787 cites W2009964743 @default.
- W2600508787 cites W2013809659 @default.
- W2600508787 cites W2015426350 @default.
- W2600508787 cites W2020401915 @default.
- W2600508787 cites W2022103979 @default.
- W2600508787 cites W2024770437 @default.
- W2600508787 cites W2033558463 @default.
- W2600508787 cites W2037001268 @default.
- W2600508787 cites W2037177764 @default.
- W2600508787 cites W2037844026 @default.
- W2600508787 cites W2044420805 @default.
- W2600508787 cites W2046491231 @default.
- W2600508787 cites W2050686330 @default.
- W2600508787 cites W2050967951 @default.
- W2600508787 cites W2053113711 @default.
- W2600508787 cites W2054846013 @default.
- W2600508787 cites W2059577689 @default.
- W2600508787 cites W2060703524 @default.
- W2600508787 cites W2061953874 @default.
- W2600508787 cites W2064748241 @default.
- W2600508787 cites W2067935544 @default.
- W2600508787 cites W2067950565 @default.
- W2600508787 cites W2071768086 @default.
- W2600508787 cites W2072365286 @default.
- W2600508787 cites W2072622582 @default.
- W2600508787 cites W2084870914 @default.
- W2600508787 cites W2087304693 @default.
- W2600508787 cites W2089296341 @default.
- W2600508787 cites W2094930349 @default.
- W2600508787 cites W2096701787 @default.
- W2600508787 cites W2101766473 @default.
- W2600508787 cites W2121365228 @default.
- W2600508787 cites W2125318318 @default.
- W2600508787 cites W2127426618 @default.
- W2600508787 cites W2129654697 @default.
- W2600508787 cites W2142313080 @default.
- W2600508787 cites W2146263938 @default.
- W2600508787 cites W2158561409 @default.
- W2600508787 cites W2410706800 @default.
- W2600508787 cites W249278890 @default.
- W2600508787 cites W3025655743 @default.
- W2600508787 cites W4211244795 @default.
- W2600508787 cites W4285719527 @default.
- W2600508787 cites W4296759751 @default.
- W2600508787 doi "https://doi.org/10.1038/s41598-017-00275-9" @default.
- W2600508787 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5427978" @default.
- W2600508787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28348377" @default.
- W2600508787 hasPublicationYear "2017" @default.
- W2600508787 type Work @default.
- W2600508787 sameAs 2600508787 @default.
- W2600508787 citedByCount "18" @default.
- W2600508787 countsByYear W26005087872017 @default.
- W2600508787 countsByYear W26005087872018 @default.
- W2600508787 countsByYear W26005087872019 @default.
- W2600508787 countsByYear W26005087872020 @default.
- W2600508787 countsByYear W26005087872021 @default.
- W2600508787 countsByYear W26005087872022 @default.
- W2600508787 countsByYear W26005087872023 @default.
- W2600508787 crossrefType "journal-article" @default.