Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600521737> ?p ?o ?g. }
- W2600521737 abstract "Significance Bacterial voltage-gated sodium channels serve as models of their vertebrate counterparts because they have similar functional components in a simpler structure. We present high-resolution structures of tightly closed and open states. In the closed state, the activation gate fully occludes the conduction pathway, and the intracellular C-terminal domain is revealed as a long four-helix bundle. In the open state, the activation gate has an orifice of ∼10 Å. Molecular dynamics simulations confirm that this conformation would allow permeation of hydrated Na + . These structures are significant advances because they provide a complete closed–open–inactivated conformational cycle in a single voltage-gated sodium channel and give insight into the structural basis for state-dependent binding of sodium channel-blocking drugs." @default.
- W2600521737 created "2017-04-07" @default.
- W2600521737 creator A5027714697 @default.
- W2600521737 creator A5047634468 @default.
- W2600521737 creator A5049773158 @default.
- W2600521737 creator A5050210290 @default.
- W2600521737 creator A5073631915 @default.
- W2600521737 creator A5076945305 @default.
- W2600521737 creator A5078941732 @default.
- W2600521737 date "2017-03-27" @default.
- W2600521737 modified "2023-10-12" @default.
- W2600521737 title "Structures of closed and open states of a voltage-gated sodium channel" @default.
- W2600521737 cites W1031578623 @default.
- W2600521737 cites W1145688032 @default.
- W2600521737 cites W1539796472 @default.
- W2600521737 cites W1595347157 @default.
- W2600521737 cites W1612947177 @default.
- W2600521737 cites W1963480981 @default.
- W2600521737 cites W1966078827 @default.
- W2600521737 cites W1969577194 @default.
- W2600521737 cites W1976255701 @default.
- W2600521737 cites W1976499671 @default.
- W2600521737 cites W1978498560 @default.
- W2600521737 cites W1983187084 @default.
- W2600521737 cites W1987382493 @default.
- W2600521737 cites W1990771438 @default.
- W2600521737 cites W1991794210 @default.
- W2600521737 cites W1993584057 @default.
- W2600521737 cites W2000123899 @default.
- W2600521737 cites W2008100921 @default.
- W2600521737 cites W2011683030 @default.
- W2600521737 cites W2014953544 @default.
- W2600521737 cites W2015233467 @default.
- W2600521737 cites W2017757683 @default.
- W2600521737 cites W2020448043 @default.
- W2600521737 cites W2022124227 @default.
- W2600521737 cites W2025625972 @default.
- W2600521737 cites W2027408247 @default.
- W2600521737 cites W2029110257 @default.
- W2600521737 cites W2029288395 @default.
- W2600521737 cites W2032008654 @default.
- W2600521737 cites W2035687084 @default.
- W2600521737 cites W2039835476 @default.
- W2600521737 cites W2041638382 @default.
- W2600521737 cites W2042147650 @default.
- W2600521737 cites W2045493336 @default.
- W2600521737 cites W2053837540 @default.
- W2600521737 cites W2054058473 @default.
- W2600521737 cites W2056248932 @default.
- W2600521737 cites W2059013803 @default.
- W2600521737 cites W2060872117 @default.
- W2600521737 cites W2066414494 @default.
- W2600521737 cites W2067174909 @default.
- W2600521737 cites W2077082977 @default.
- W2600521737 cites W2080769511 @default.
- W2600521737 cites W2085980752 @default.
- W2600521737 cites W2095581992 @default.
- W2600521737 cites W2101299936 @default.
- W2600521737 cites W2104415321 @default.
- W2600521737 cites W2106207499 @default.
- W2600521737 cites W2108793171 @default.
- W2600521737 cites W2116411564 @default.
- W2600521737 cites W2122316595 @default.
- W2600521737 cites W2124653618 @default.
- W2600521737 cites W2129206515 @default.
- W2600521737 cites W2139042077 @default.
- W2600521737 cites W2139852988 @default.
- W2600521737 cites W2141273392 @default.
- W2600521737 cites W2149946800 @default.
- W2600521737 cites W2156008447 @default.
- W2600521737 cites W2158426869 @default.
- W2600521737 cites W2161962584 @default.
- W2600521737 cites W2163052762 @default.
- W2600521737 cites W2163706259 @default.
- W2600521737 cites W2167460294 @default.
- W2600521737 cites W2180229411 @default.
- W2600521737 cites W2236818481 @default.
- W2600521737 cites W2271846309 @default.
- W2600521737 cites W2278844416 @default.
- W2600521737 cites W2293843772 @default.
- W2600521737 cites W2323178299 @default.
- W2600521737 cites W2408234862 @default.
- W2600521737 cites W2585542808 @default.
- W2600521737 cites W863411863 @default.
- W2600521737 doi "https://doi.org/10.1073/pnas.1700761114" @default.
- W2600521737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5393245" @default.
- W2600521737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28348242" @default.
- W2600521737 hasPublicationYear "2017" @default.
- W2600521737 type Work @default.
- W2600521737 sameAs 2600521737 @default.
- W2600521737 citedByCount "130" @default.
- W2600521737 countsByYear W26005217372017 @default.
- W2600521737 countsByYear W26005217372018 @default.
- W2600521737 countsByYear W26005217372019 @default.
- W2600521737 countsByYear W26005217372020 @default.
- W2600521737 countsByYear W26005217372021 @default.
- W2600521737 countsByYear W26005217372022 @default.
- W2600521737 countsByYear W26005217372023 @default.
- W2600521737 crossrefType "journal-article" @default.
- W2600521737 hasAuthorship W2600521737A5027714697 @default.