Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600559783> ?p ?o ?g. }
- W2600559783 endingPage "1479" @default.
- W2600559783 startingPage "1468" @default.
- W2600559783 abstract "Listeria monocytogenes is a major intracellular human foodborne bacterial pathogen. We previously revealed L. monocytogenes cadC as highly expressed during mouse infection. Here we show that L. monocytogenes CadC is a sequence-specific, DNA-binding and cadmium-dependent regulator of CadA, an efflux pump conferring cadmium resistance. CadC but not CadA is required for L. monocytogenes infection in vivo. Interestingly, CadC also directly represses lspB, a gene encoding a lipoprotein signal peptidase whose expression appears detrimental for infection. lspB overexpression promotes the release of the LpeA lipoprotein to the extracellular medium, inducing tumor necrosis factor α and interleukin 6 expression, thus impairing L. monocytogenes survival in macrophages. We propose that L. monocytogenes uses CadC to repress lspB expression during infection to avoid LpeA exposure to the host immune system, diminishing inflammatory cytokine expression and promoting intramacrophagic survival and virulence. CadC appears as the first metal efflux pump regulator repurposed during infection to fine-tune lipoprotein processing and host responses." @default.
- W2600559783 created "2017-04-07" @default.
- W2600559783 creator A5004453222 @default.
- W2600559783 creator A5004936398 @default.
- W2600559783 creator A5014984934 @default.
- W2600559783 creator A5032761824 @default.
- W2600559783 creator A5048294474 @default.
- W2600559783 creator A5050483821 @default.
- W2600559783 creator A5069188872 @default.
- W2600559783 creator A5075414397 @default.
- W2600559783 creator A5082419541 @default.
- W2600559783 date "2017-03-23" @default.
- W2600559783 modified "2023-10-16" @default.
- W2600559783 title "Listeria monocytogenes CadC Regulates Cadmium Efflux and Fine-tunes Lipoprotein Localization to Escape the Host Immune Response and Promote Infection" @default.
- W2600559783 cites W1490820480 @default.
- W2600559783 cites W1497550398 @default.
- W2600559783 cites W1521710501 @default.
- W2600559783 cites W1535518980 @default.
- W2600559783 cites W1602952910 @default.
- W2600559783 cites W1775175420 @default.
- W2600559783 cites W1902607909 @default.
- W2600559783 cites W1962972365 @default.
- W2600559783 cites W1973821443 @default.
- W2600559783 cites W2011557428 @default.
- W2600559783 cites W2019056562 @default.
- W2600559783 cites W2020336506 @default.
- W2600559783 cites W2027232611 @default.
- W2600559783 cites W2028033589 @default.
- W2600559783 cites W2035752210 @default.
- W2600559783 cites W2036062926 @default.
- W2600559783 cites W2043961065 @default.
- W2600559783 cites W2044942649 @default.
- W2600559783 cites W2048053078 @default.
- W2600559783 cites W2052581796 @default.
- W2600559783 cites W2058244557 @default.
- W2600559783 cites W2059206113 @default.
- W2600559783 cites W2060993079 @default.
- W2600559783 cites W2071212473 @default.
- W2600559783 cites W2084077452 @default.
- W2600559783 cites W2084521089 @default.
- W2600559783 cites W2090895095 @default.
- W2600559783 cites W2092576643 @default.
- W2600559783 cites W2098167270 @default.
- W2600559783 cites W2107277218 @default.
- W2600559783 cites W2107993914 @default.
- W2600559783 cites W2111310696 @default.
- W2600559783 cites W2120194191 @default.
- W2600559783 cites W2120218267 @default.
- W2600559783 cites W2121860020 @default.
- W2600559783 cites W2122375895 @default.
- W2600559783 cites W2122566973 @default.
- W2600559783 cites W2129937025 @default.
- W2600559783 cites W2136163749 @default.
- W2600559783 cites W2141462914 @default.
- W2600559783 cites W2157176179 @default.
- W2600559783 cites W2162824216 @default.
- W2600559783 cites W2163334446 @default.
- W2600559783 cites W2169715845 @default.
- W2600559783 cites W2889884634 @default.
- W2600559783 doi "https://doi.org/10.1093/infdis/jix118" @default.
- W2600559783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28368435" @default.
- W2600559783 hasPublicationYear "2017" @default.
- W2600559783 type Work @default.
- W2600559783 sameAs 2600559783 @default.
- W2600559783 citedByCount "23" @default.
- W2600559783 countsByYear W26005597832018 @default.
- W2600559783 countsByYear W26005597832020 @default.
- W2600559783 countsByYear W26005597832021 @default.
- W2600559783 countsByYear W26005597832022 @default.
- W2600559783 countsByYear W26005597832023 @default.
- W2600559783 crossrefType "journal-article" @default.
- W2600559783 hasAuthorship W2600559783A5004453222 @default.
- W2600559783 hasAuthorship W2600559783A5004936398 @default.
- W2600559783 hasAuthorship W2600559783A5014984934 @default.
- W2600559783 hasAuthorship W2600559783A5032761824 @default.
- W2600559783 hasAuthorship W2600559783A5048294474 @default.
- W2600559783 hasAuthorship W2600559783A5050483821 @default.
- W2600559783 hasAuthorship W2600559783A5069188872 @default.
- W2600559783 hasAuthorship W2600559783A5075414397 @default.
- W2600559783 hasAuthorship W2600559783A5082419541 @default.
- W2600559783 hasBestOaLocation W26005597831 @default.
- W2600559783 hasConcept C17991360 @default.
- W2600559783 hasConcept C200082930 @default.
- W2600559783 hasConcept C203014093 @default.
- W2600559783 hasConcept C2778690821 @default.
- W2600559783 hasConcept C2781350384 @default.
- W2600559783 hasConcept C523546767 @default.
- W2600559783 hasConcept C54355233 @default.
- W2600559783 hasConcept C55493867 @default.
- W2600559783 hasConcept C86803240 @default.
- W2600559783 hasConcept C8891405 @default.
- W2600559783 hasConcept C89423630 @default.
- W2600559783 hasConcept C95444343 @default.
- W2600559783 hasConceptScore W2600559783C17991360 @default.
- W2600559783 hasConceptScore W2600559783C200082930 @default.
- W2600559783 hasConceptScore W2600559783C203014093 @default.
- W2600559783 hasConceptScore W2600559783C2778690821 @default.
- W2600559783 hasConceptScore W2600559783C2781350384 @default.