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• W2600561071 endingPage "2687" @default.
• W2600561071 startingPage "2679" @default.
• W2600561071 abstract "miRNA-27a-3p is an important regulator of carcinogenesis and other pathological processes. However, its role in laryngeal carcinoma is still unknown. In our previous research, we found that miR-27a-3p expression was upregulated in nasopharyngeal carcinoma (NPC) using a microarray chip. In the present study, we identified miR-27a-3p as an endogenous promoter of metastatic invasion. The expression levels of miR-27a-3p were correlated with human metastatic progression outcomes and Kaplan-Meier survival. In silico database analyses revealed that Mapk10 is a potential target of miR-27a-3p, and luciferase reporter assay results revealed that miR-27a-3p directly inhibits the Mapk10 3' untranslated region (3'UTR). Real-time PCR and western blotting results ascertained that Mapk10 expression was regulated by miR‑27a-3p. In addition, miR‑27a-3p gain-of-function promoted cell proliferation, migration and invasion in 5-8 F NPC cells. These effects partially depended on Mapk10, and loss of miR‑27a-3p function had the opposite effects." @default.
• W2600561071 created "2017-04-07" @default.
• W2600561071 creator A5037511763 @default.
• W2600561071 creator A5076042378 @default.
• W2600561071 date "2017-03-31" @default.
• W2600561071 modified "2023-10-14" @default.
• W2600561071 title "Dysregulated miR-27a-3p promotes nasopharyngeal carcinoma cell proliferation and migration by targeting Mapk10" @default.
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• W2600561071 doi "https://doi.org/10.3892/or.2017.5544" @default.
• W2600561071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5428281" @default.
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• W2600561071 hasPublicationYear "2017" @default.
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