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• W2600576046 abstract "Following the continuous accumulation of evidence supporting the beneficial role of reducing low-density lipoprotein cholesterol (LDL-C) levels in the treatment and prevention of atherosclerotic cardiovascular disease and its complications, therapeutic possibilities now exist to lower LDL-C to very low levels, similar to or even lower than those seen in newborns and nonhuman species. In addition to the important task of evaluating potential side effects of such treatments, the question arises whether extremely low LDL-C levels per se may provoke adverse effects in humans. In this review, we summarize information from studies of human cellular and organ physiology, phenotypic characterization of rare genetic diseases of lipid metabolism, and experience from clinical trials. Specifically, we emphasize the importance of the robustness of the regulatory systems that maintain balanced fluxes and levels of cholesterol at both cellular and organismal levels. Even at extremely low LDL-C levels, critical capacities of steroid hormone and bile acid production are preserved, and the presence of a cholesterol blood-brain barrier protects cells in the central nervous system. Apparent relationships sometimes reported between less pronounced low LDL-C levels and disease states such as cancer, depression, infectious disease and others can generally be explained as secondary phenomena. Drug-related side effects including an increased propensity for development of type 2 diabetes occur during statin treatment, whilst further evaluation of more potent LDL-lowering treatments such as PCSK9 inhibitors is needed. Experience from the recently reported and ongoing large event-driven trials are of great interest, and further evaluation including careful analysis of cognitive functions will be important." @default.
• W2600576046 created "2017-04-07" @default.
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• W2600576046 date "2017-05-18" @default.
• W2600576046 modified "2023-10-14" @default.
• W2600576046 title "Can LDL cholesterol be too low? Possible risks of extremely low levels" @default.
• W2600576046 cites W1564684786 @default.
• W2600576046 cites W1586368641 @default.
• W2600576046 cites W166112863 @default.
• W2600576046 cites W1742641335 @default.
• W2600576046 cites W1923289550 @default.
• W2600576046 cites W1967021869 @default.
• W2600576046 cites W1970049038 @default.
• W2600576046 cites W1975192101 @default.
• W2600576046 cites W1976998758 @default.
• W2600576046 cites W1992963452 @default.
• W2600576046 cites W1998600489 @default.
• W2600576046 cites W1999474253 @default.
• W2600576046 cites W2001328643 @default.
• W2600576046 cites W2006427893 @default.
• W2600576046 cites W2008823657 @default.
• W2600576046 cites W2011664867 @default.
• W2600576046 cites W2012799874 @default.
• W2600576046 cites W2014263073 @default.
• W2600576046 cites W2015190417 @default.
• W2600576046 cites W2016808531 @default.
• W2600576046 cites W2017864976 @default.
• W2600576046 cites W2018991776 @default.
• W2600576046 cites W2028597436 @default.
• W2600576046 cites W2031455450 @default.
• W2600576046 cites W2033883349 @default.
• W2600576046 cites W2035513334 @default.
• W2600576046 cites W2036843552 @default.
• W2600576046 cites W2040612932 @default.
• W2600576046 cites W2045315353 @default.
• W2600576046 cites W2054489926 @default.
• W2600576046 cites W2060460124 @default.
• W2600576046 cites W2062853193 @default.
• W2600576046 cites W2067539811 @default.
• W2600576046 cites W2068963865 @default.
• W2600576046 cites W2069616685 @default.
• W2600576046 cites W2069888529 @default.
• W2600576046 cites W2081026800 @default.
• W2600576046 cites W2084857951 @default.
• W2600576046 cites W2088626229 @default.
• W2600576046 cites W2090464684 @default.
• W2600576046 cites W2090849567 @default.
• W2600576046 cites W2091144312 @default.
• W2600576046 cites W2092054388 @default.
• W2600576046 cites W2093637414 @default.
• W2600576046 cites W2097510503 @default.
• W2600576046 cites W2099136586 @default.
• W2600576046 cites W2103108681 @default.
• W2600576046 cites W2104020340 @default.
• W2600576046 cites W2106129883 @default.
• W2600576046 cites W2106814701 @default.
• W2600576046 cites W2106931191 @default.
• W2600576046 cites W2106937178 @default.
• W2600576046 cites W2117842413 @default.
• W2600576046 cites W2118882750 @default.
• W2600576046 cites W2121261412 @default.
• W2600576046 cites W2122803675 @default.
• W2600576046 cites W2122864632 @default.
• W2600576046 cites W2125580354 @default.
• W2600576046 cites W2126100780 @default.
• W2600576046 cites W2127445212 @default.
• W2600576046 cites W2129809363 @default.
• W2600576046 cites W2133025814 @default.
• W2600576046 cites W2135631433 @default.
• W2600576046 cites W2137415370 @default.
• W2600576046 cites W2140622082 @default.
• W2600576046 cites W2142527465 @default.
• W2600576046 cites W2142769596 @default.
• W2600576046 cites W2147259528 @default.
• W2600576046 cites W2148653677 @default.
• W2600576046 cites W2158642508 @default.
• W2600576046 cites W2160347316 @default.
• W2600576046 cites W2163488353 @default.
• W2600576046 cites W2165791625 @default.
• W2600576046 cites W2175943040 @default.
• W2600576046 cites W2186002170 @default.
• W2600576046 cites W2219679120 @default.
• W2600576046 cites W2255347090 @default.

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