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• W2600583347 abstract "Diabetes mellitus is a major public health problem in the world. The prevalence ofdiabetes mellitus is increasing with ageing of the population and lifestyle changesassociated with rapid urbanization and westernization. According to the WorldHealth Organization estimate 3% of the world’s populations (194 million) havediabetes and is expected to double (6.3%) by the year 2025 and that of Ethiopia wasabout 800,000 cases in 2000, and the number is expected to increase to 1.8 millionby 2030.Stevia rebaudiana Bertoni (Asteraceae) and Ajuga remota Benth (Lamiaceae) hasbeen used for the treatment of diabetes mellitus and various other ailments in thetraditional medical system world wide. This study reports the antidiabetic activity ofcrude extracts of Stevia rebaudiana Bertoni & Ajuga remota Benth grown in Ethiopiaon alloxan-induced diabetic miceA preliminary toxicity study of S. rebaudiana and A. remota crude extracts was doneusing Swiss albino mice in oral doses of 1000, 2000 and 5000 mg/kg body weight.The result showed that the medium lethal dose (LD50) of the extracts is higher than5000 mg/kg body weight and hence, in a single dose administration, the plantextracts had no adverse effect. The result obtained is in agreement with that ofGeuns (2003) for S. rebaudiana and Worku (2005) for A. remota.The preliminary phytochemical screening indicated the presence of flavonoids,saponins, tannins and steroids in both plants and alkaloids in the leaves of S.rebaudiana. Extracts of both plants did not contain anthraquinones. The resultobtained here is in agreement with that of Anonymous-a (1999) for S. rebaudianaand Worku (2005) for A. remota.A concentration of 2.27 % stevioside was obtained in the leaves of S. rebaudiana.The antihyperglycemic activity of the crude aqueous and ethanol extracts of S.rebaudiana and A. remota were studied in alloxan-induced (200 mg/kg body weight,ip.) diabetic mice, after oral administration at a dose of 300 and 500 mg/kg bodyweight for two weeks. Administration of crude aqueous extract of S. rebaudiana for14 days lowered elevated blood glucose levels by 30.27% (300 mg/kg) and 42.65%(500 mg/kg) that shows S. rebaudiana has retained its antidiabetic activity whengrown out of its natural habitat, i.e. in Ethiopia. In the case of A. remota, bloodglucose reduction was 27.96% and 38.98% respectively for the dose levels tested.Crude ethanol extract of S. rebaudiana and A. remota (300 and 500 mg/kg bodyweight for 14 days) lowered blood glucose level by 28.71% & 33.04% and 28.09% &28.25% respectively as compared with diabetic untreated mice. Treatment with theknown antidiabetic drug, glibenclamide (10 mg/kg body weight) lowered bloodglucose level by 51.06%. The effect was more pronounced in the case of the crudeaqueous extract as compared with the crude ethanol extract on the respective doselimits for both plant cases" @default.
• W2600583347 created "2017-04-07" @default.
• W2600583347 creator A5037368620 @default.
• W2600583347 date "2008-04-01" @default.
• W2600583347 modified "2023-09-23" @default.
• W2600583347 title "Antidiabetic Activity and phytochemical Screening of Crude extracts of Stevia rebaudiana Bertoni and Ajuga Remota Benth Grown in Ethiopia on Alloxan-induced Diabetic Mice" @default.
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