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• W2600584706 abstract "// Elettra Merola 1 , Francesco Panzuto 1 and Gianfranco Delle Fave 1 1 Department of Digestive and Liver Diseases, Sapienza University, Sant’Andrea Hospital, Rome, Italy Correspondence to: Gianfranco Delle Fave, email: // Keywords : gastro-entero-pancreatic neuroendocrine tumors, somatostatin analogs, antiproliferative effect, meta-analysis Received : January 20, 2017 Accepted : March 17, 2017 Published : March 29, 2017 Abstract A meta-analysis has systematically investigated the antineoplastic efficacy and safety of somatostatin analogs (SSAs) in advanced gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs). Randomized controlled trials (RCTs) reporting the hazard ratio (HR) for disease progression (DP) were evaluated. Response rate and risk ratio (RR) for adverse events were also analyzed. A total of 289 patients (143 receiving SSAs vs . 146 placebo) were evaluated from two RCTs. A significant benefit from SSAs in terms of disease control was observed (HR 0.41, 95% CI: 0.29 to 0.58, P < 0.01; I 2 0%), response rate being 58.0% vs . 32.2%, respectively.The occurrence of adverse events significantly differed from the placebo arm only in terms of biliary stones (RR 3.79, 95% CI: 1.28 to 11.17, P = 0.02; I 2 0%). In conclusion, SSAs showed an antiproliferative effect in advanced GEP-NETs, with a good safety profile." @default.
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• W2600584706 date "2017-03-29" @default.
• W2600584706 modified "2023-09-26" @default.
• W2600584706 title "Antiproliferative effect of somatostatin analogs in advanced gastro-entero-pancreatic neuroendocrine tumors: a systematic review and meta-analysis" @default.
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• W2600584706 doi "https://doi.org/10.18632/oncotarget.16686" @default.
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