FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600605000> ?p ?o ?g. }

• W2600605000 endingPage "76" @default.
• W2600605000 startingPage "69" @default.
• W2600605000 abstract "Breviscapine is a flavonoid derived from a traditional Chinese herb Erigerin breviscapus (Vant.) Hand-Mazz, and has been extensively used in clinical treatment for cerebral stroke in China, but the underlying pharmacological mechanisms are still unclear. In present study, we investigated whether breviscapine could confer a neuroprotection against cerebral ischemia injury by targeting autophagy mechanisms. A cerebral stroke model in Sprague-Dawley rats was prepared by middle cerebral artery occlusion (MCAO), rats were then randomly divided into 5 groups: MCAO + Bre group, rats were treated with breviscapine; MCAO + Tat-Beclin-1 group, animals were administrated with specific autophagy inducer Tat-Beclin-1; MCAO + Bre + Tat-Beclin-1 group, rats were treated with both breviscapine and Tat-Beclin-1, MCAO + saline group, rats received the same volume of physiological saline, and Sham surgery group. The autophagy levels in infarct penumbra were evaluated by western blotting, real-time PCR and immunofluorescence 7 days after the insult. Meanwhile, infarct volume, brain water content and neurological deficit score were assessed. The results illustrated that the infarct volume, brain water content and neurofunctional deficiency were significantly reduced by 7 days of breviscapine treatment in MCAO + Bre group, compared with those in MCAO + saline group. Meanwhile, the western blotting, quantitative PCR and immunofluorescence showed that the autophagy in both neurons and astrocytes at the penumbra were markedly attenuated by breviscapine admininstration. Moreover, these pharmacological effects of breviscapine could be counteracted by autophagy inducer Tat-Beclin-1. Our study suggests that breviscapine can provide a neuroprotection against transient focal cerebral ischemia, and this biological function is associated with attenuating autophagy in both neurons and astrocytes." @default.
• W2600605000 created "2017-04-07" @default.
• W2600605000 creator A5025824737 @default.
• W2600605000 creator A5046329118 @default.
• W2600605000 creator A5076330540 @default.
• W2600605000 creator A5086969004 @default.
• W2600605000 creator A5091474960 @default.
• W2600605000 date "2017-06-01" @default.
• W2600605000 modified "2023-10-17" @default.
• W2600605000 title "Breviscapine confers a neuroprotective efficacy against transient focal cerebral ischemia by attenuating neuronal and astrocytic autophagy in the penumbra" @default.
• W2600605000 cites W1013428084 @default.
• W2600605000 cites W1523367786 @default.
• W2600605000 cites W1594425991 @default.
• W2600605000 cites W1968922340 @default.
• W2600605000 cites W1972336737 @default.
• W2600605000 cites W1982726600 @default.
• W2600605000 cites W1990216374 @default.
• W2600605000 cites W1994757585 @default.
• W2600605000 cites W1995914841 @default.
• W2600605000 cites W2000132737 @default.
• W2600605000 cites W2003899957 @default.
• W2600605000 cites W2005179639 @default.
• W2600605000 cites W2005717420 @default.
• W2600605000 cites W2007997314 @default.
• W2600605000 cites W2009052322 @default.
• W2600605000 cites W2009610505 @default.
• W2600605000 cites W2011783556 @default.
• W2600605000 cites W2013043771 @default.
• W2600605000 cites W2020097343 @default.
• W2600605000 cites W2043291430 @default.
• W2600605000 cites W2044553450 @default.
• W2600605000 cites W2048230571 @default.
• W2600605000 cites W2054436439 @default.
• W2600605000 cites W2059738518 @default.
• W2600605000 cites W2064827446 @default.
• W2600605000 cites W2068153705 @default.
• W2600605000 cites W2083521073 @default.
• W2600605000 cites W2089963577 @default.
• W2600605000 cites W2092639266 @default.
• W2600605000 cites W2103864988 @default.
• W2600605000 cites W2105536017 @default.
• W2600605000 cites W2109030151 @default.
• W2600605000 cites W2110090329 @default.
• W2600605000 cites W2114542837 @default.
• W2600605000 cites W2115772647 @default.
• W2600605000 cites W2130167079 @default.
• W2600605000 cites W2135398540 @default.
• W2600605000 cites W2160935383 @default.
• W2600605000 cites W2161594732 @default.
• W2600605000 cites W2164778558 @default.
• W2600605000 cites W2190909122 @default.
• W2600605000 cites W2236292981 @default.
• W2600605000 cites W2315469249 @default.
• W2600605000 doi "https://doi.org/10.1016/j.biopha.2017.03.039" @default.
• W2600605000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28343073" @default.
• W2600605000 hasPublicationYear "2017" @default.
• W2600605000 type Work @default.
• W2600605000 sameAs 2600605000 @default.
• W2600605000 citedByCount "44" @default.
• W2600605000 countsByYear W26006050002017 @default.
• W2600605000 countsByYear W26006050002018 @default.
• W2600605000 countsByYear W26006050002019 @default.
• W2600605000 countsByYear W26006050002020 @default.
• W2600605000 countsByYear W26006050002021 @default.
• W2600605000 countsByYear W26006050002022 @default.
• W2600605000 countsByYear W26006050002023 @default.
• W2600605000 crossrefType "journal-article" @default.
• W2600605000 hasAuthorship W2600605000A5025824737 @default.
• W2600605000 hasAuthorship W2600605000A5046329118 @default.
• W2600605000 hasAuthorship W2600605000A5076330540 @default.
• W2600605000 hasAuthorship W2600605000A5086969004 @default.
• W2600605000 hasAuthorship W2600605000A5091474960 @default.
• W2600605000 hasConcept C102652120 @default.
• W2600605000 hasConcept C104317684 @default.
• W2600605000 hasConcept C126322002 @default.
• W2600605000 hasConcept C127413603 @default.
• W2600605000 hasConcept C185592680 @default.
• W2600605000 hasConcept C190283241 @default.
• W2600605000 hasConcept C203522944 @default.
• W2600605000 hasConcept C25498285 @default.
• W2600605000 hasConcept C2776415932 @default.
• W2600605000 hasConcept C2777397205 @default.
• W2600605000 hasConcept C2780577055 @default.
• W2600605000 hasConcept C2780645631 @default.
• W2600605000 hasConcept C42219234 @default.
• W2600605000 hasConcept C541997718 @default.
• W2600605000 hasConcept C55493867 @default.
• W2600605000 hasConcept C71924100 @default.
• W2600605000 hasConcept C78519656 @default.
• W2600605000 hasConcept C85265743 @default.
• W2600605000 hasConcept C98274493 @default.
• W2600605000 hasConceptScore W2600605000C102652120 @default.
• W2600605000 hasConceptScore W2600605000C104317684 @default.
• W2600605000 hasConceptScore W2600605000C126322002 @default.
• W2600605000 hasConceptScore W2600605000C127413603 @default.
• W2600605000 hasConceptScore W2600605000C185592680 @default.
• W2600605000 hasConceptScore W2600605000C190283241 @default.
• W2600605000 hasConceptScore W2600605000C203522944 @default.

• next