Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600614482> ?p ?o ?g. }
- W2600614482 endingPage "1198" @default.
- W2600614482 startingPage "1187" @default.
- W2600614482 abstract "Cancer stem cells possess self-renewal and chemoresistance activities. However, the manner in which these features are maintained remains obscure. We sought to identify cell surface protein(s) that mark self-renewing and chemoresistant gastric cancer cells using the explorer antibody microarray. We identified PMP22, a target gene of the Wnt/β-catenin pathway, as the most upregulated cell surface protein in gastric cancer xenografts exposed to cisplatin (DDP). PMP22 expression was markedly upregulated in tumorspheric cells and declined with differentiation. Infecting gastric cancer cells with lentivirus expressing PMP22 shRNAs reduced proliferation, tumorsphere formation, and chemoresistance to cisplatin in vitro and in NOD/SCID mice. When combined with bortezomib, a PMP22 inhibitor, the chemotherapeutic sensitivity to cisplatin treatment was dramatically increased by inducing cell apoptosis in cultured cells and xenograft mouse models. Finally, mRNA expression levels of PMP22 were detected in 38 tumor specimens from patients who received six cycles of perioperative chemotherapy. A strong correlation between PMP22 level and tumor recurrence was revealed, thus showing a pivotal role of PMP22 in the clinical chemoresistance of gastric cancer. Our study is the first to show the role of PMP22 in gastric cancer stemness and chemoresistance and reveals a potential new target for the diagnosis and treatment of recurrent gastric cancer. Mol Cancer Ther; 16(6); 1187-98. ©2017 AACR." @default.
- W2600614482 created "2017-04-07" @default.
- W2600614482 creator A5008584660 @default.
- W2600614482 creator A5009235748 @default.
- W2600614482 creator A5036717941 @default.
- W2600614482 creator A5036749692 @default.
- W2600614482 creator A5041748603 @default.
- W2600614482 creator A5045067652 @default.
- W2600614482 creator A5057434864 @default.
- W2600614482 creator A5061756846 @default.
- W2600614482 creator A5062253563 @default.
- W2600614482 creator A5089673632 @default.
- W2600614482 date "2017-06-01" @default.
- W2600614482 modified "2023-09-24" @default.
- W2600614482 title "PMP22 Regulates Self-Renewal and Chemoresistance of Gastric Cancer Cells" @default.
- W2600614482 cites W1505803934 @default.
- W2600614482 cites W1596376889 @default.
- W2600614482 cites W1703447549 @default.
- W2600614482 cites W1868273877 @default.
- W2600614482 cites W1947301506 @default.
- W2600614482 cites W1967115244 @default.
- W2600614482 cites W1973148453 @default.
- W2600614482 cites W1979249872 @default.
- W2600614482 cites W1986989569 @default.
- W2600614482 cites W1988750760 @default.
- W2600614482 cites W2003973093 @default.
- W2600614482 cites W2013522138 @default.
- W2600614482 cites W2019199359 @default.
- W2600614482 cites W2020099839 @default.
- W2600614482 cites W2020124057 @default.
- W2600614482 cites W2020131167 @default.
- W2600614482 cites W2024520801 @default.
- W2600614482 cites W2028126854 @default.
- W2600614482 cites W2030847614 @default.
- W2600614482 cites W2032036028 @default.
- W2600614482 cites W2036678165 @default.
- W2600614482 cites W2048233457 @default.
- W2600614482 cites W2051528388 @default.
- W2600614482 cites W2052085965 @default.
- W2600614482 cites W2053363358 @default.
- W2600614482 cites W2055904567 @default.
- W2600614482 cites W2062316045 @default.
- W2600614482 cites W2069579711 @default.
- W2600614482 cites W2071261047 @default.
- W2600614482 cites W2075313370 @default.
- W2600614482 cites W2083274861 @default.
- W2600614482 cites W2106210966 @default.
- W2600614482 cites W2106369700 @default.
- W2600614482 cites W2112008630 @default.
- W2600614482 cites W2116166429 @default.
- W2600614482 cites W2122959101 @default.
- W2600614482 cites W2127107445 @default.
- W2600614482 cites W2127617517 @default.
- W2600614482 cites W2131596261 @default.
- W2600614482 cites W2132943380 @default.
- W2600614482 cites W2134357876 @default.
- W2600614482 cites W2140926801 @default.
- W2600614482 cites W2146074268 @default.
- W2600614482 cites W2149843709 @default.
- W2600614482 cites W2272984102 @default.
- W2600614482 cites W2399143289 @default.
- W2600614482 doi "https://doi.org/10.1158/1535-7163.mct-16-0750" @default.
- W2600614482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28336807" @default.
- W2600614482 hasPublicationYear "2017" @default.
- W2600614482 type Work @default.
- W2600614482 sameAs 2600614482 @default.
- W2600614482 citedByCount "36" @default.
- W2600614482 countsByYear W26006144822017 @default.
- W2600614482 countsByYear W26006144822018 @default.
- W2600614482 countsByYear W26006144822019 @default.
- W2600614482 countsByYear W26006144822020 @default.
- W2600614482 countsByYear W26006144822021 @default.
- W2600614482 countsByYear W26006144822022 @default.
- W2600614482 countsByYear W26006144822023 @default.
- W2600614482 crossrefType "journal-article" @default.
- W2600614482 hasAuthorship W2600614482A5008584660 @default.
- W2600614482 hasAuthorship W2600614482A5009235748 @default.
- W2600614482 hasAuthorship W2600614482A5036717941 @default.
- W2600614482 hasAuthorship W2600614482A5036749692 @default.
- W2600614482 hasAuthorship W2600614482A5041748603 @default.
- W2600614482 hasAuthorship W2600614482A5045067652 @default.
- W2600614482 hasAuthorship W2600614482A5057434864 @default.
- W2600614482 hasAuthorship W2600614482A5061756846 @default.
- W2600614482 hasAuthorship W2600614482A5062253563 @default.
- W2600614482 hasAuthorship W2600614482A5089673632 @default.
- W2600614482 hasBestOaLocation W26006144822 @default.
- W2600614482 hasConcept C104317684 @default.
- W2600614482 hasConcept C121608353 @default.
- W2600614482 hasConcept C126322002 @default.
- W2600614482 hasConcept C127561419 @default.
- W2600614482 hasConcept C137620995 @default.
- W2600614482 hasConcept C190283241 @default.
- W2600614482 hasConcept C203014093 @default.
- W2600614482 hasConcept C2776364478 @default.
- W2600614482 hasConcept C2776694085 @default.
- W2600614482 hasConcept C2777478702 @default.
- W2600614482 hasConcept C2778239845 @default.
- W2600614482 hasConcept C502942594 @default.