FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600697048> ?p ?o ?g. }

• W2600697048 endingPage "48819" @default.
• W2600697048 startingPage "48807" @default.
• W2600697048 abstract "// Huihan Wang 1, * , Weili Yan 2, * , Shumei Zhang 1, * , Yue Gu 1 , Yihan Wang 1 , Yanjun Wei 1 , Hongbo Liu 1 , Fang Wang 1 , Qiong Wu 2 and Yan Zhang 1 1 College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China 2 School of Life Science and Technology, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150001, China * Joint first authors Correspondence to: Yan Zhang, email: tyozhang@ems.hrbmu.edu.cn Keywords: CpG island methylator phenotype (CIMP), breast cancer, copy number alteration (CNA), prognosis, biomarker Received: June 29, 2016      Accepted: March 01, 2017      Published: March 14, 2017 ABSTRACT CpG island methylator phenotype of breast cancer is associated with widespread aberrant methylation at specified CpG islands and distinct patient outcomes. However, the influence of copy number contributing to the prognosis of tumors with different CpG island methylator phenotypes is still unclear. We analyzed both genetic (copy number) and epigenetic alterations in 765 breast cancers from The Cancer Genome Atlas data portal and got a panel of 15 biomarkers for copy number and methylation status evaluation. The gene panel identified two groups corresponding to distinct copy number profiles. In status of mere-loss copy number, patients were faced with a greater risk if they presented a higher CpG islands methylation pattern in biomarker panels. But for samples presenting merely-gained copy number, higher methylation level of CpG islands was associated with improved viability. In all, the integration of copy number alteration and methylation information enhanced the classification power on prognosis. Moreover, we found the molecular subtypes of breast cancer presented different distributions in two CpG island methylation phenotypes. Generated by the same set of human methylation 450K data, additional copy number information could provide insights into survival prediction of cancers with less heterogeneity and might help to determine the biomarkers for diagnosis and treatment for breast cancer patients in a more personalized approach." @default.
• W2600697048 created "2017-04-07" @default.
• W2600697048 creator A5002661071 @default.
• W2600697048 creator A5011489796 @default.
• W2600697048 creator A5019221209 @default.
• W2600697048 creator A5031958482 @default.
• W2600697048 creator A5056869329 @default.
• W2600697048 creator A5068862707 @default.
• W2600697048 creator A5082437921 @default.
• W2600697048 creator A5086664284 @default.
• W2600697048 creator A5087981683 @default.
• W2600697048 creator A5091786108 @default.
• W2600697048 date "2017-03-14" @default.
• W2600697048 modified "2023-09-25" @default.
• W2600697048 title "Survival differences of CIMP subtypes integrated with CNA information in human breast cancer" @default.
• W2600697048 cites W1504303645 @default.
• W2600697048 cites W1580258410 @default.
• W2600697048 cites W1602272174 @default.
• W2600697048 cites W1882219601 @default.
• W2600697048 cites W1973516848 @default.
• W2600697048 cites W1973767578 @default.
• W2600697048 cites W1975066506 @default.
• W2600697048 cites W1983115477 @default.
• W2600697048 cites W1986352281 @default.
• W2600697048 cites W1996588677 @default.
• W2600697048 cites W2017502278 @default.
• W2600697048 cites W2029484950 @default.
• W2600697048 cites W2035690710 @default.
• W2600697048 cites W2036640908 @default.
• W2600697048 cites W2044702943 @default.
• W2600697048 cites W2048939997 @default.
• W2600697048 cites W2054818135 @default.
• W2600697048 cites W2057037007 @default.
• W2600697048 cites W2064854706 @default.
• W2600697048 cites W2089508330 @default.
• W2600697048 cites W2096283457 @default.
• W2600697048 cites W2098570483 @default.
• W2600697048 cites W2102466421 @default.
• W2600697048 cites W2105528101 @default.
• W2600697048 cites W2107665951 @default.
• W2600697048 cites W2108956458 @default.
• W2600697048 cites W2116401585 @default.
• W2600697048 cites W2118775306 @default.
• W2600697048 cites W2130330090 @default.
• W2600697048 cites W2131658210 @default.
• W2600697048 cites W2132738255 @default.
• W2600697048 cites W2136895197 @default.
• W2600697048 cites W2145680370 @default.
• W2600697048 cites W2147415859 @default.
• W2600697048 cites W2148064779 @default.
• W2600697048 cites W2161922342 @default.
• W2600697048 cites W2166466845 @default.
• W2600697048 cites W2166657289 @default.
• W2600697048 cites W2168764008 @default.
• W2600697048 cites W2169903102 @default.
• W2600697048 cites W2171340242 @default.
• W2600697048 cites W2560367415 @default.
• W2600697048 doi "https://doi.org/10.18632/oncotarget.16178" @default.
• W2600697048 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5564726" @default.
• W2600697048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28415743" @default.
• W2600697048 hasPublicationYear "2017" @default.
• W2600697048 type Work @default.
• W2600697048 sameAs 2600697048 @default.
• W2600697048 citedByCount "3" @default.
• W2600697048 countsByYear W26006970482018 @default.
• W2600697048 countsByYear W26006970482022 @default.
• W2600697048 countsByYear W26006970482023 @default.
• W2600697048 crossrefType "journal-article" @default.
• W2600697048 hasAuthorship W2600697048A5002661071 @default.
• W2600697048 hasAuthorship W2600697048A5011489796 @default.
• W2600697048 hasAuthorship W2600697048A5019221209 @default.
• W2600697048 hasAuthorship W2600697048A5031958482 @default.
• W2600697048 hasAuthorship W2600697048A5056869329 @default.
• W2600697048 hasAuthorship W2600697048A5068862707 @default.
• W2600697048 hasAuthorship W2600697048A5082437921 @default.
• W2600697048 hasAuthorship W2600697048A5086664284 @default.
• W2600697048 hasAuthorship W2600697048A5087981683 @default.
• W2600697048 hasAuthorship W2600697048A5091786108 @default.
• W2600697048 hasBestOaLocation W26006970481 @default.
• W2600697048 hasConcept C104317684 @default.
• W2600697048 hasConcept C120821319 @default.
• W2600697048 hasConcept C121608353 @default.
• W2600697048 hasConcept C140173407 @default.
• W2600697048 hasConcept C141231307 @default.
• W2600697048 hasConcept C143998085 @default.
• W2600697048 hasConcept C150194340 @default.
• W2600697048 hasConcept C190727270 @default.
• W2600697048 hasConcept C2781197716 @default.
• W2600697048 hasConcept C33288867 @default.
• W2600697048 hasConcept C41091548 @default.
• W2600697048 hasConcept C502942594 @default.
• W2600697048 hasConcept C530470458 @default.
• W2600697048 hasConcept C54355233 @default.
• W2600697048 hasConcept C60644358 @default.
• W2600697048 hasConcept C71924100 @default.
• W2600697048 hasConcept C86803240 @default.
• W2600697048 hasConceptScore W2600697048C104317684 @default.
• W2600697048 hasConceptScore W2600697048C120821319 @default.

• next