FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600733265> ?p ?o ?g. }

• W2600733265 abstract "High-throughput DNA sequencing technologies have revolutionized genomic analysis, including the de novo assembly of whole genomes from single organisms or metagenomic samples. However, due to the limited capacity of short-read sequence data to assemble complex or low coverage regions, genomes are typically fragmented, leading to draft genomes with numerous underexplored large genomic regions. Revealing these missing sequences is a major goal to resolve concerns in numerous biological studies. To overcome these limitations, we developed an innovative target enrichment method for the reconstruction of large unknown genomic regions. Based on a hybridization capture strategy, this approach enables the enrichment of large genomic regions allowing the reconstruction of tens of kilobase pairs flanking a short, targeted DNA sequence. Applied to a metagenomic soil sample targeting the linA gene, the biomarker of hexachlorocyclohexane (HCH) degradation, our method permitted the enrichment of the gene and its flanking regions leading to the reconstruction of several contigs and complete plasmids exceeding tens of kilobase pairs surrounding linA. Thus, through gene association and genome reconstruction, we identified microbial species involved in HCH degradation which constitute targets to improve biostimulation treatments. This new hybridization capture strategy makes surveying and deconvoluting complex genomic regions possible through large genomic regions enrichment and allows the efficient exploration of metagenomic diversity. Indeed, this approach enables to assign identity and function to microorganisms in natural environments, one of the ultimate goals of microbial ecology." @default.
• W2600733265 created "2017-04-07" @default.
• W2600733265 creator A5002447097 @default.
• W2600733265 creator A5048794537 @default.
• W2600733265 date "2017-03-14" @default.
• W2600733265 modified "2023-09-25" @default.
• W2600733265 title "Revealing large metagenomic regions through long DNA fragment hybridization capture" @default.
• W2600733265 cites W1486087545 @default.
• W2600733265 cites W1549700459 @default.
• W2600733265 cites W1618614343 @default.
• W2600733265 cites W1899545975 @default.
• W2600733265 cites W2001820495 @default.
• W2600733265 cites W2015759847 @default.
• W2600733265 cites W2024117328 @default.
• W2600733265 cites W2039156006 @default.
• W2600733265 cites W2080656716 @default.
• W2600733265 cites W2096772815 @default.
• W2600733265 cites W2108077038 @default.
• W2600733265 cites W2108234281 @default.
• W2600733265 cites W2108640362 @default.
• W2600733265 cites W2113168385 @default.
• W2600733265 cites W2114861865 @default.
• W2600733265 cites W2118001436 @default.
• W2600733265 cites W2121180999 @default.
• W2600733265 cites W2129288227 @default.
• W2600733265 cites W2136895820 @default.
• W2600733265 cites W2137064107 @default.
• W2600733265 cites W2140175819 @default.
• W2600733265 cites W2141920662 @default.
• W2600733265 cites W2143420371 @default.
• W2600733265 cites W2147575903 @default.
• W2600733265 cites W2148391952 @default.
• W2600733265 cites W2153746848 @default.
• W2600733265 cites W2157624015 @default.
• W2600733265 cites W2158804744 @default.
• W2600733265 cites W2166265186 @default.
• W2600733265 cites W2170551349 @default.
• W2600733265 cites W2211504288 @default.
• W2600733265 cites W2237525495 @default.
• W2600733265 cites W2332650756 @default.
• W2600733265 cites W2339327716 @default.
• W2600733265 cites W2439131540 @default.
• W2600733265 cites W2462868993 @default.
• W2600733265 cites W2516183252 @default.
• W2600733265 cites W872882560 @default.
• W2600733265 doi "https://doi.org/10.1186/s40168-017-0251-0" @default.
• W2600733265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5351058" @default.
• W2600733265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28292322" @default.
• W2600733265 hasPublicationYear "2017" @default.
• W2600733265 type Work @default.
• W2600733265 sameAs 2600733265 @default.
• W2600733265 citedByCount "5" @default.
• W2600733265 countsByYear W26007332652018 @default.
• W2600733265 countsByYear W26007332652019 @default.
• W2600733265 countsByYear W26007332652020 @default.
• W2600733265 countsByYear W26007332652021 @default.
• W2600733265 crossrefType "journal-article" @default.
• W2600733265 hasAuthorship W2600733265A5002447097 @default.
• W2600733265 hasAuthorship W2600733265A5048794537 @default.
• W2600733265 hasBestOaLocation W26007332651 @default.
• W2600733265 hasConcept C104317684 @default.
• W2600733265 hasConcept C141231307 @default.
• W2600733265 hasConcept C150194340 @default.
• W2600733265 hasConcept C15151743 @default.
• W2600733265 hasConcept C162317418 @default.
• W2600733265 hasConcept C189206191 @default.
• W2600733265 hasConcept C18949551 @default.
• W2600733265 hasConcept C51679486 @default.
• W2600733265 hasConcept C54355233 @default.
• W2600733265 hasConcept C59582021 @default.
• W2600733265 hasConcept C70721500 @default.
• W2600733265 hasConcept C86803240 @default.
• W2600733265 hasConceptScore W2600733265C104317684 @default.
• W2600733265 hasConceptScore W2600733265C141231307 @default.
• W2600733265 hasConceptScore W2600733265C150194340 @default.
• W2600733265 hasConceptScore W2600733265C15151743 @default.
• W2600733265 hasConceptScore W2600733265C162317418 @default.
• W2600733265 hasConceptScore W2600733265C189206191 @default.
• W2600733265 hasConceptScore W2600733265C18949551 @default.
• W2600733265 hasConceptScore W2600733265C51679486 @default.
• W2600733265 hasConceptScore W2600733265C54355233 @default.
• W2600733265 hasConceptScore W2600733265C59582021 @default.
• W2600733265 hasConceptScore W2600733265C70721500 @default.
• W2600733265 hasConceptScore W2600733265C86803240 @default.
• W2600733265 hasIssue "1" @default.
• W2600733265 hasLocation W26007332651 @default.
• W2600733265 hasLocation W26007332652 @default.
• W2600733265 hasLocation W26007332653 @default.
• W2600733265 hasLocation W26007332654 @default.
• W2600733265 hasLocation W26007332655 @default.
• W2600733265 hasLocation W26007332656 @default.
• W2600733265 hasLocation W26007332657 @default.
• W2600733265 hasLocation W26007332658 @default.
• W2600733265 hasOpenAccess W2600733265 @default.
• W2600733265 hasPrimaryLocation W26007332651 @default.
• W2600733265 hasRelatedWork W2078447778 @default.
• W2600733265 hasRelatedWork W2097029864 @default.
• W2600733265 hasRelatedWork W2099006507 @default.
• W2600733265 hasRelatedWork W2166395958 @default.
• W2600733265 hasRelatedWork W2255506873 @default.

• next