Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600776803> ?p ?o ?g. }
- W2600776803 abstract "Langerhans cells (LCs) are able to orchestrate adaptive immune responses in the skin by interpreting the microenvironmental context in which they encounter foreign substances, but the regulatory basis for this has not been established. Utilising systems immunology approaches combining in silico modelling of a reconstructed gene regulatory network (GRN) with in vitro validation of the predictions, we sought to determine the mechanisms of regulation of immune responses in human primary LCs. The key role of Interferon regulatory factors (IRFs) as controllers of the human Langerhans cell response to epidermal cytokines was revealed by whole transcriptome analysis. Applying Boolean logic we assembled a Petri net-based model of the IRF-GRN which provides molecular pathway predictions for the induction of different transcriptional programmes in LCs. In silico simulations performed after model parameterisation with transcription factor expression values predicted that human LC activation of antigen-specific CD8 T cells would be differentially regulated by epidermal cytokine induction of specific IRF-controlled pathways. This was confirmed by in vitro measurement of IFN-γ production by activated T cells. As a proof of concept, this approach shows that stochastic modelling of a specific immune networks renders transcriptome data valuable for the prediction of functional outcomes of immune responses." @default.
- W2600776803 created "2017-04-07" @default.
- W2600776803 creator A5000564084 @default.
- W2600776803 creator A5027137275 @default.
- W2600776803 creator A5033489749 @default.
- W2600776803 creator A5046355810 @default.
- W2600776803 creator A5047471475 @default.
- W2600776803 date "2017-04-06" @default.
- W2600776803 modified "2023-09-27" @default.
- W2600776803 title "Petri Net computational modelling of Langerhans cell Interferon Regulatory Factor Network predicts their role in T cell activation" @default.
- W2600776803 cites W133158124 @default.
- W2600776803 cites W1512789086 @default.
- W2600776803 cites W1538233951 @default.
- W2600776803 cites W1541596409 @default.
- W2600776803 cites W1590845979 @default.
- W2600776803 cites W1752957211 @default.
- W2600776803 cites W1775929199 @default.
- W2600776803 cites W1906782505 @default.
- W2600776803 cites W1966211860 @default.
- W2600776803 cites W1967540945 @default.
- W2600776803 cites W1968458512 @default.
- W2600776803 cites W1968461883 @default.
- W2600776803 cites W1977070803 @default.
- W2600776803 cites W1977689261 @default.
- W2600776803 cites W1981858801 @default.
- W2600776803 cites W1984387148 @default.
- W2600776803 cites W1989945566 @default.
- W2600776803 cites W1993489331 @default.
- W2600776803 cites W2001042507 @default.
- W2600776803 cites W2001764493 @default.
- W2600776803 cites W2005104821 @default.
- W2600776803 cites W2006766086 @default.
- W2600776803 cites W2007222211 @default.
- W2600776803 cites W2018043147 @default.
- W2600776803 cites W2021006448 @default.
- W2600776803 cites W2021385433 @default.
- W2600776803 cites W2024068846 @default.
- W2600776803 cites W2024354448 @default.
- W2600776803 cites W2024696581 @default.
- W2600776803 cites W2026443363 @default.
- W2600776803 cites W2026602389 @default.
- W2600776803 cites W2026932044 @default.
- W2600776803 cites W2031369606 @default.
- W2600776803 cites W2033245528 @default.
- W2600776803 cites W2045164356 @default.
- W2600776803 cites W2045328071 @default.
- W2600776803 cites W2046781420 @default.
- W2600776803 cites W2054296281 @default.
- W2600776803 cites W2054779024 @default.
- W2600776803 cites W2056198580 @default.
- W2600776803 cites W2057941036 @default.
- W2600776803 cites W2060307820 @default.
- W2600776803 cites W2061440101 @default.
- W2600776803 cites W2062029454 @default.
- W2600776803 cites W2065391646 @default.
- W2600776803 cites W2066580949 @default.
- W2600776803 cites W2068284940 @default.
- W2600776803 cites W2074097004 @default.
- W2600776803 cites W2074546623 @default.
- W2600776803 cites W2076870975 @default.
- W2600776803 cites W2079386574 @default.
- W2600776803 cites W2086692340 @default.
- W2600776803 cites W2087109205 @default.
- W2600776803 cites W2090775309 @default.
- W2600776803 cites W2094168446 @default.
- W2600776803 cites W2101011890 @default.
- W2600776803 cites W2101026971 @default.
- W2600776803 cites W2104295028 @default.
- W2600776803 cites W2104499325 @default.
- W2600776803 cites W2105559737 @default.
- W2600776803 cites W2114156659 @default.
- W2600776803 cites W2117253480 @default.
- W2600776803 cites W2120276586 @default.
- W2600776803 cites W2122561013 @default.
- W2600776803 cites W2123298166 @default.
- W2600776803 cites W2124277087 @default.
- W2600776803 cites W2124649657 @default.
- W2600776803 cites W2127623109 @default.
- W2600776803 cites W2136964674 @default.
- W2600776803 cites W2137522673 @default.
- W2600776803 cites W2139708137 @default.
- W2600776803 cites W2140053284 @default.
- W2600776803 cites W2148357359 @default.
- W2600776803 cites W2149462058 @default.
- W2600776803 cites W2151572058 @default.
- W2600776803 cites W2151875002 @default.
- W2600776803 cites W2155400409 @default.
- W2600776803 cites W2156948997 @default.
- W2600776803 cites W2159885517 @default.
- W2600776803 cites W2162166699 @default.
- W2600776803 cites W2163051906 @default.
- W2600776803 cites W2167192576 @default.
- W2600776803 cites W2170938416 @default.
- W2600776803 cites W2337684584 @default.
- W2600776803 cites W2479009306 @default.
- W2600776803 cites W2789682581 @default.
- W2600776803 doi "https://doi.org/10.1038/s41598-017-00651-5" @default.
- W2600776803 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5428800" @default.
- W2600776803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28386100" @default.
- W2600776803 hasPublicationYear "2017" @default.