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- W2600800301 abstract "Eukaryotes possess a vast array of RNA-binding proteins (RBPs) that affect mRNAs in diverse ways to control protein expression. Combinatorial regulation of mRNAs by RBPs is emerging as the rule. No example illustrates this as vividly as the partnership of 3 Drosophila RBPs, Pumilio, Nanos and Brain Tumor, which have overlapping functions in development, stem cell maintenance and differentiation, fertility and neurologic processes. Here we synthesize 30 y of research with new insights into their molecular functions and mechanisms of action. First, we provide an overview of the key properties of each RBP. Next, we present a detailed analysis of their collaborative regulatory mechanism using a classic example of the developmental morphogen, hunchback, which is spatially and temporally regulated by the trio during embryogenesis. New biochemical, structural and functional analyses provide insights into RNA recognition, cooperativity, and regulatory mechanisms. We integrate these data into a model of combinatorial RNA binding and regulation of translation and mRNA decay. We then use this information, transcriptome wide analyses and bioinformatics predictions to assess the global impact of Pumilio, Nanos and Brain Tumor on gene regulation. Together, the results support pervasive, dynamic post-transcriptional control." @default.
- W2600800301 created "2017-04-07" @default.
- W2600800301 creator A5000082412 @default.
- W2600800301 creator A5001041847 @default.
- W2600800301 creator A5014076234 @default.
- W2600800301 creator A5014823244 @default.
- W2600800301 date "2017-04-17" @default.
- W2600800301 modified "2023-10-02" @default.
- W2600800301 title "Combinatorial control of messenger RNAs by Pumilio, Nanos and Brain Tumor Proteins" @default.
- W2600800301 cites W1507545655 @default.
- W2600800301 cites W1606301060 @default.
- W2600800301 cites W1854634446 @default.
- W2600800301 cites W1924561767 @default.
- W2600800301 cites W1927341546 @default.
- W2600800301 cites W1952752962 @default.
- W2600800301 cites W1963587334 @default.
- W2600800301 cites W1964595381 @default.
- W2600800301 cites W1968240450 @default.
- W2600800301 cites W1978654362 @default.
- W2600800301 cites W1979521848 @default.
- W2600800301 cites W1981336776 @default.
- W2600800301 cites W1981340767 @default.
- W2600800301 cites W1981401436 @default.
- W2600800301 cites W1982512914 @default.
- W2600800301 cites W1982823751 @default.
- W2600800301 cites W1986911150 @default.
- W2600800301 cites W1991437365 @default.
- W2600800301 cites W1993115402 @default.
- W2600800301 cites W1997535872 @default.
- W2600800301 cites W1997664026 @default.
- W2600800301 cites W1999322507 @default.
- W2600800301 cites W2004410438 @default.
- W2600800301 cites W2014908429 @default.
- W2600800301 cites W2025075195 @default.
- W2600800301 cites W2025613787 @default.
- W2600800301 cites W2028630156 @default.
- W2600800301 cites W2036598706 @default.
- W2600800301 cites W2037783502 @default.
- W2600800301 cites W2038179327 @default.
- W2600800301 cites W2041440237 @default.
- W2600800301 cites W2043730199 @default.
- W2600800301 cites W2043757623 @default.
- W2600800301 cites W2045947182 @default.
- W2600800301 cites W2046524002 @default.
- W2600800301 cites W2047956182 @default.
- W2600800301 cites W2048728930 @default.
- W2600800301 cites W2048834802 @default.
- W2600800301 cites W2049003872 @default.
- W2600800301 cites W2053219805 @default.
- W2600800301 cites W2057738635 @default.
- W2600800301 cites W2058220225 @default.
- W2600800301 cites W2064983298 @default.
- W2600800301 cites W2065818009 @default.
- W2600800301 cites W2066483986 @default.
- W2600800301 cites W2066484804 @default.
- W2600800301 cites W2071712215 @default.
- W2600800301 cites W2072300667 @default.
- W2600800301 cites W2078724155 @default.
- W2600800301 cites W2079228796 @default.
- W2600800301 cites W2080182910 @default.
- W2600800301 cites W2080932211 @default.
- W2600800301 cites W2085940390 @default.
- W2600800301 cites W2086964845 @default.
- W2600800301 cites W2095974123 @default.
- W2600800301 cites W2100050856 @default.
- W2600800301 cites W2101998972 @default.
- W2600800301 cites W2105694586 @default.
- W2600800301 cites W2106613806 @default.
- W2600800301 cites W2106801137 @default.
- W2600800301 cites W2107660867 @default.
- W2600800301 cites W2111069555 @default.
- W2600800301 cites W2111166800 @default.
- W2600800301 cites W2116824785 @default.
- W2600800301 cites W2117921076 @default.
- W2600800301 cites W2121040242 @default.
- W2600800301 cites W2122114053 @default.
- W2600800301 cites W2122486844 @default.
- W2600800301 cites W2124219423 @default.
- W2600800301 cites W2126036680 @default.
- W2600800301 cites W2128794934 @default.
- W2600800301 cites W2130615249 @default.
- W2600800301 cites W2138077148 @default.
- W2600800301 cites W2139044529 @default.
- W2600800301 cites W2140986784 @default.
- W2600800301 cites W2144614846 @default.
- W2600800301 cites W2152136268 @default.
- W2600800301 cites W2153368605 @default.
- W2600800301 cites W2154179678 @default.
- W2600800301 cites W2157191293 @default.
- W2600800301 cites W2158375643 @default.
- W2600800301 cites W2159095015 @default.
- W2600800301 cites W2159107837 @default.
- W2600800301 cites W2160680240 @default.
- W2600800301 cites W2166708209 @default.
- W2600800301 cites W2168380638 @default.
- W2600800301 cites W2169300762 @default.
- W2600800301 cites W2181464620 @default.
- W2600800301 cites W2257097671 @default.