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- W2600875771 abstract "Objective: Severe malaria and cerebral malaria reportedly causes cognitive deficits in young children, post-treatments. We investigated the antiplasmodial, histomorphological and immunohistochemical effects of ethanolic leaf extract of Nauclea latifolia (NL) on the hippocampus of Swiss albino mice infected with Plasmodium berghei. Methods: Twenty male mice were divided into four groups of five mice each as follows: Group 1 (control) was given 10 ml/kg of normal saline (0.9% Nacl); Group 2 received extract of NL 500 mg/kg body weight of mice. Group 3 received 1000 mg/kg body weight of mice. Group 4 received 5 mg/kg body weight of mice. All mice were passaged with the 0.2ml of infected erythrocytes containing approximately 1x106 of P. berghei via intraperitoneal injection before treatment. Baseline parasitemia was determined by direct enumeration on day 5 post infection, then treatment commenced for five days, thereafter mice were humanely sacrificed via ketamine/xylaxine cocktail, and brain dissected for light microscopy, and immunohistochemical detection of glial fibrillary acidic protein (GFAP) expression in the hippocampus. Result: P. berghei infection was significantly (p<0.05) decreased in NL ethanolic extract groups at dose dependent levels, but decreased most in the Artemether/Lumefantrine groups. Histomorphology revealed severely distorted hippocampus in group 1 (P. berghei-infected only); petechial haemorrhage in the low dose extract, but ameliorated distortions in NL 1000 mg/kg and 5mg Artemether/Lumefantrine groups. GFAP was intensely expressed in group 1, moderate in 2, but down-regulated in group 3 and 4 indicating a decline in induced oxidative stress to neuronal cells and neuropil by the extract and Artemether/Lumefantrine. Conclusion: The ethanolic extract of NL via its phytochemical bioavailability decreases P. berghei in dose dependent manner, and offers moderate neuro-protection to hippocampus of infected mice, down-regulating inflammatory protein in curative malaria model; thus may support their wide use in ethnopharmacology, we are investigating the activity of their fractions and pure compounds in other antimalarial models." @default.
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- W2600875771 date "2017-01-01" @default.
- W2600875771 modified "2023-09-26" @default.
- W2600875771 title "Histopathological Effect of Nauclea latifolia Ethanolic Leaf Extract and Artemether/Lumefantrine on the Hippocampus of P. berghei -Infected Mice" @default.
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