FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600876860> ?p ?o ?g. }

• W2600876860 endingPage "685" @default.
• W2600876860 startingPage "676" @default.
• W2600876860 abstract "A major hallmark of Alzheimer's disease (AD) is the formation of neurotoxic aggregates composed of the amyloid-β peptide (Aβ). Aβ has been recognized to interact with numerous proteins, resulting in pathological changes to the metabolism of patients with AD. One such mitochondrial metabolic enzyme is amyloid-binding alcohol dehydrogenase (ABAD), where altered enzyme function caused by the Aβ-ABAD interaction is known to cause mitochondrial distress and cytotoxic effects, providing a feasible therapeutic target for AD drug development. Here we have established a high-throughput screening platform for the identification of modulators to the ABAD enzyme. A pilot screen with a total of 6759 compounds from the NIH Clinical Collections (NCC) and SelleckChem libraries and a selection of compounds from the BioAscent diversity collection have allowed validation and robustness to be optimized. The pilot screen revealed 16 potential inhibitors in the low µM range against ABAD with favorable physicochemical properties for blood-brain barrier penetration." @default.
• W2600876860 created "2017-04-07" @default.
• W2600876860 creator A5025124106 @default.
• W2600876860 creator A5036760813 @default.
• W2600876860 creator A5039259126 @default.
• W2600876860 creator A5067495919 @default.
• W2600876860 creator A5071396108 @default.
• W2600876860 creator A5086350788 @default.
• W2600876860 creator A5089740171 @default.
• W2600876860 creator A5090400191 @default.
• W2600876860 date "2017-07-01" @default.
• W2600876860 modified "2023-10-14" @default.
• W2600876860 title "In Vitro Assay Development and HTS of Small-Molecule Human ABAD/17β-HSD10 Inhibitors as Therapeutics in Alzheimer’s Disease" @default.
• W2600876860 cites W1782048590 @default.
• W2600876860 cites W1819750950 @default.
• W2600876860 cites W1969547229 @default.
• W2600876860 cites W1971513938 @default.
• W2600876860 cites W1977085392 @default.
• W2600876860 cites W1980481704 @default.
• W2600876860 cites W1991001144 @default.
• W2600876860 cites W1997514006 @default.
• W2600876860 cites W2013361289 @default.
• W2600876860 cites W2034997501 @default.
• W2600876860 cites W2057360427 @default.
• W2600876860 cites W2065343204 @default.
• W2600876860 cites W2074372568 @default.
• W2600876860 cites W2074682587 @default.
• W2600876860 cites W2085073705 @default.
• W2600876860 cites W2085861615 @default.
• W2600876860 cites W2089966673 @default.
• W2600876860 cites W2103440561 @default.
• W2600876860 cites W2117037463 @default.
• W2600876860 cites W2138765938 @default.
• W2600876860 cites W2163757074 @default.
• W2600876860 cites W2217972427 @default.
• W2600876860 cites W2298560668 @default.
• W2600876860 cites W2413814368 @default.
• W2600876860 cites W4248107770 @default.
• W2600876860 cites W91818796 @default.
• W2600876860 doi "https://doi.org/10.1177/2472555217697964" @default.
• W2600876860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28314118" @default.
• W2600876860 hasPublicationYear "2017" @default.
• W2600876860 type Work @default.
• W2600876860 sameAs 2600876860 @default.
• W2600876860 citedByCount "13" @default.
• W2600876860 countsByYear W26008768602018 @default.
• W2600876860 countsByYear W26008768602019 @default.
• W2600876860 countsByYear W26008768602020 @default.
• W2600876860 countsByYear W26008768602021 @default.
• W2600876860 countsByYear W26008768602022 @default.
• W2600876860 countsByYear W26008768602023 @default.
• W2600876860 crossrefType "journal-article" @default.
• W2600876860 hasAuthorship W2600876860A5025124106 @default.
• W2600876860 hasAuthorship W2600876860A5036760813 @default.
• W2600876860 hasAuthorship W2600876860A5039259126 @default.
• W2600876860 hasAuthorship W2600876860A5067495919 @default.
• W2600876860 hasAuthorship W2600876860A5071396108 @default.
• W2600876860 hasAuthorship W2600876860A5086350788 @default.
• W2600876860 hasAuthorship W2600876860A5089740171 @default.
• W2600876860 hasAuthorship W2600876860A5090400191 @default.
• W2600876860 hasBestOaLocation W26008768601 @default.
• W2600876860 hasConcept C142724271 @default.
• W2600876860 hasConcept C1491633281 @default.
• W2600876860 hasConcept C157044486 @default.
• W2600876860 hasConcept C169760540 @default.
• W2600876860 hasConcept C181199279 @default.
• W2600876860 hasConcept C185592680 @default.
• W2600876860 hasConcept C202751555 @default.
• W2600876860 hasConcept C2778402981 @default.
• W2600876860 hasConcept C2779134260 @default.
• W2600876860 hasConcept C2780035454 @default.
• W2600876860 hasConcept C502032728 @default.
• W2600876860 hasConcept C51323132 @default.
• W2600876860 hasConcept C529278444 @default.
• W2600876860 hasConcept C53227056 @default.
• W2600876860 hasConcept C55493867 @default.
• W2600876860 hasConcept C70721500 @default.
• W2600876860 hasConcept C71924100 @default.
• W2600876860 hasConcept C74187038 @default.
• W2600876860 hasConcept C86803240 @default.
• W2600876860 hasConcept C98274493 @default.
• W2600876860 hasConceptScore W2600876860C142724271 @default.
• W2600876860 hasConceptScore W2600876860C1491633281 @default.
• W2600876860 hasConceptScore W2600876860C157044486 @default.
• W2600876860 hasConceptScore W2600876860C169760540 @default.
• W2600876860 hasConceptScore W2600876860C181199279 @default.
• W2600876860 hasConceptScore W2600876860C185592680 @default.
• W2600876860 hasConceptScore W2600876860C202751555 @default.
• W2600876860 hasConceptScore W2600876860C2778402981 @default.
• W2600876860 hasConceptScore W2600876860C2779134260 @default.
• W2600876860 hasConceptScore W2600876860C2780035454 @default.
• W2600876860 hasConceptScore W2600876860C502032728 @default.
• W2600876860 hasConceptScore W2600876860C51323132 @default.
• W2600876860 hasConceptScore W2600876860C529278444 @default.
• W2600876860 hasConceptScore W2600876860C53227056 @default.
• W2600876860 hasConceptScore W2600876860C55493867 @default.
• W2600876860 hasConceptScore W2600876860C70721500 @default.
• W2600876860 hasConceptScore W2600876860C71924100 @default.

• next