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• W2600887625 abstract "6-Shogaol, a pungent agent isolated from Zingiber officinale Roscoe, has been known to have anti-tumor and anti-inflammatory effects. However, the anti-inflammatory effects and biological mechanism of 6-Shogaol in LPS-activated BV2 microglia remains largely unknown. In this study, we evaluated the anti-inflammatory effects of 6-Shogaol in LPS-activated BV2 microglia. 6-Shogaol was administrated 1 h before LPS treatment. The production of inflammatory mediators were detected by ELISA. The expression of NF-κB and PPAR-γ were detected by western blot analysis. Our results revealed that 6-Shogaol inhibited LPS-induced TNF-α, IL-1β, IL-6, and PGE2 production in a concentration dependent manner. Furthermore, 6-Shogaol inhibited LPS-induced NF-κB activation by inhibiting phosphorylation and nuclear translocation of NF-κB p65. In addition, 6-Shogaol could increase the expression of PPAR-γ. Moreover, inhibition of PPAR-γ by GW9662 could prevent the inhibition of 6-Shogaol on LPS-induced inflammatory mediator production. In conclusion, 6-Shogaol inhibits LPS-induced inflammation by activating PPAR-γ." @default.
• W2600887625 created "2017-04-07" @default.
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• W2600887625 date "2017-03-30" @default.
• W2600887625 modified "2023-10-18" @default.
• W2600887625 title "6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-γ" @default.
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• W2600887625 doi "https://doi.org/10.18632/oncotarget.16719" @default.
• W2600887625 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5522044" @default.
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