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- W2600889251 abstract "Chronic pain and depression affect millions of people worldwide. These conditions often occur together in a comorbid manner. Most medications used to treat these conditions separately target G-protein coupled receptors (GPCRs), suggesting that there may be receptors that could be targeted to jointly address both pain and affective symptoms. Our labs use a natural product approach to search for novel compounds that bind to GPCRs. Specifically, we target and isolate peptide-like molecules from marine cyanobacteria. Cyanobacteria have been found to produce secondary metabolites that resemble endogenous ligands to GPCRs. Several cyanobacterial samples were collected from Las Perlas Archipelago off of the coast of Panama in the Pacific Ocean and from Curacao in the Caribbean Sea for investigation. The 16S rRNA gene for several collections was sequenced for phylogenetic analysis with the goal of finding meaningful relationships between cyanobacteria that could be used for more directed collection trips. We also explored how our collections are related to previously discovered cyanobacterial species known to produce bioactive molecules. We took into account environmental factors, including depth, growing substrate and water clarity and how these factors related to each collection’s psychoactive potential. By exploring these relationships, we hope to gain a better understanding of how to use these marine organisms as an alternative source for finding compounds to treat comorbid pain and depression." @default.
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- W2600889251 date "2017-04-01" @default.
- W2600889251 modified "2023-09-27" @default.
- W2600889251 title "(164) Phylogenetic relationships of cyanobacteria serving as possible targets for pain and depression" @default.
- W2600889251 doi "https://doi.org/10.1016/j.jpain.2017.02.070" @default.
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