FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600891502> ?p ?o ?g. }

• W2600891502 endingPage "1570" @default.
• W2600891502 startingPage "1570" @default.
• W2600891502 abstract "1570 Background: Analysis of exhaled volatile organic compounds (VOCs) in breath is an emerging approach for cancer diagnosis, but little is known about its potential use as a biomarker for colorectal cancer (CRC). We investigated whether a combination of VOCs could distinct CRC patients from healthy volunteers. Methods: In a pilot study, we prospectively analyzed breath exhalations of 38 CRC patient and 43 healthy controls all scheduled for colonoscopy, older than 50 in the average-risk category. The samples were ionized and analyzed using a Secondary ElectroSpray Ionization (SESI) coupled with a Time-of-Flight Mass Spectrometer (SESI-MS). After a minimum of 2 hours fasting, volunteers deeply exhaled into the system. Each test requires three soft exhalations and takes less than ten minutes. No breath condensate or collection are required and VOCs masses are detected in real time, also allowing for a spirometric profile to be analyzed along with the VOCs. A new sampling system precludes ambient air from entering the system, so background contamination is reduced by an overall factor of ten. Potential confounding variables from the patient or the environment that could interfere with results were analyzed. Results: 255 VOCs, with masses ranging from 30 to 431 Dalton have been identified in the exhaled breath. Using a classification technique based on the ROC curve for each VOC, a set of 9 biomarkers discriminating the presence of CRC from healthy volunteers was obtained, showing an average recognition rate of 81.94%, a sensitivity of 87.04% and specificity of 76.85%. Conclusions: A combination of cualitative and cuantitative analysis of VOCs in the exhaled breath could be a powerful diagnostic tool for average-risk CRC population. These results should be taken with precaution, as many endogenous or exogenous contaminants could interfere as confounding variables. On-line analysis with SESI-MS is less time-consuming and doesn’t need sample preparation. We are recruiting in a new pilot study including breath cleaning procedures and spirometric analysis incorporated into the postprocessing algorithms, to better control for confounding variables." @default.
• W2600891502 created "2017-04-07" @default.
• W2600891502 creator A5000204001 @default.
• W2600891502 creator A5007742147 @default.
• W2600891502 creator A5008665977 @default.
• W2600891502 creator A5009193366 @default.
• W2600891502 creator A5014929007 @default.
• W2600891502 creator A5023708212 @default.
• W2600891502 creator A5024598099 @default.
• W2600891502 creator A5032037314 @default.
• W2600891502 creator A5032851075 @default.
• W2600891502 creator A5034384514 @default.
• W2600891502 creator A5036377575 @default.
• W2600891502 creator A5043634245 @default.
• W2600891502 creator A5043673030 @default.
• W2600891502 creator A5047678330 @default.
• W2600891502 creator A5055970908 @default.
• W2600891502 creator A5066221296 @default.
• W2600891502 creator A5068335602 @default.
• W2600891502 creator A5069547035 @default.
• W2600891502 creator A5072858340 @default.
• W2600891502 date "2012-05-20" @default.
• W2600891502 modified "2023-10-18" @default.
• W2600891502 title "On-line breath analysis of volatile organic compounds as a method for colorectal cancer detection." @default.
• W2600891502 cites W2022285855 @default.
• W2600891502 cites W2149443601 @default.
• W2600891502 cites W2156161107 @default.
• W2600891502 doi "https://doi.org/10.1200/jco.2012.30.15_suppl.1570" @default.
• W2600891502 hasPublicationYear "2012" @default.
• W2600891502 type Work @default.
• W2600891502 sameAs 2600891502 @default.
• W2600891502 citedByCount "0" @default.
• W2600891502 crossrefType "journal-article" @default.
• W2600891502 hasAuthorship W2600891502A5000204001 @default.
• W2600891502 hasAuthorship W2600891502A5007742147 @default.
• W2600891502 hasAuthorship W2600891502A5008665977 @default.
• W2600891502 hasAuthorship W2600891502A5009193366 @default.
• W2600891502 hasAuthorship W2600891502A5014929007 @default.
• W2600891502 hasAuthorship W2600891502A5023708212 @default.
• W2600891502 hasAuthorship W2600891502A5024598099 @default.
• W2600891502 hasAuthorship W2600891502A5032037314 @default.
• W2600891502 hasAuthorship W2600891502A5032851075 @default.
• W2600891502 hasAuthorship W2600891502A5034384514 @default.
• W2600891502 hasAuthorship W2600891502A5036377575 @default.
• W2600891502 hasAuthorship W2600891502A5043634245 @default.
• W2600891502 hasAuthorship W2600891502A5043673030 @default.
• W2600891502 hasAuthorship W2600891502A5047678330 @default.
• W2600891502 hasAuthorship W2600891502A5055970908 @default.
• W2600891502 hasAuthorship W2600891502A5066221296 @default.
• W2600891502 hasAuthorship W2600891502A5068335602 @default.
• W2600891502 hasAuthorship W2600891502A5069547035 @default.
• W2600891502 hasAuthorship W2600891502A5072858340 @default.
• W2600891502 hasConcept C105702510 @default.
• W2600891502 hasConcept C121608353 @default.
• W2600891502 hasConcept C126322002 @default.
• W2600891502 hasConcept C178790620 @default.
• W2600891502 hasConcept C185592680 @default.
• W2600891502 hasConcept C2778150766 @default.
• W2600891502 hasConcept C2781197716 @default.
• W2600891502 hasConcept C2993216161 @default.
• W2600891502 hasConcept C43617362 @default.
• W2600891502 hasConcept C526805850 @default.
• W2600891502 hasConcept C55493867 @default.
• W2600891502 hasConcept C71924100 @default.
• W2600891502 hasConcept C93353639 @default.
• W2600891502 hasConceptScore W2600891502C105702510 @default.
• W2600891502 hasConceptScore W2600891502C121608353 @default.
• W2600891502 hasConceptScore W2600891502C126322002 @default.
• W2600891502 hasConceptScore W2600891502C178790620 @default.
• W2600891502 hasConceptScore W2600891502C185592680 @default.
• W2600891502 hasConceptScore W2600891502C2778150766 @default.
• W2600891502 hasConceptScore W2600891502C2781197716 @default.
• W2600891502 hasConceptScore W2600891502C2993216161 @default.
• W2600891502 hasConceptScore W2600891502C43617362 @default.
• W2600891502 hasConceptScore W2600891502C526805850 @default.
• W2600891502 hasConceptScore W2600891502C55493867 @default.
• W2600891502 hasConceptScore W2600891502C71924100 @default.
• W2600891502 hasConceptScore W2600891502C93353639 @default.
• W2600891502 hasIssue "15_suppl" @default.
• W2600891502 hasLocation W26008915021 @default.
• W2600891502 hasOpenAccess W2600891502 @default.
• W2600891502 hasPrimaryLocation W26008915021 @default.
• W2600891502 hasRelatedWork W1484289650 @default.
• W2600891502 hasRelatedWork W1513589221 @default.
• W2600891502 hasRelatedWork W1981667582 @default.
• W2600891502 hasRelatedWork W1996422126 @default.
• W2600891502 hasRelatedWork W2009494736 @default.
• W2600891502 hasRelatedWork W2053504644 @default.
• W2600891502 hasRelatedWork W2085134047 @default.
• W2600891502 hasRelatedWork W2280013794 @default.
• W2600891502 hasRelatedWork W2313044425 @default.
• W2600891502 hasRelatedWork W2781815299 @default.
• W2600891502 hasRelatedWork W2811101049 @default.
• W2600891502 hasRelatedWork W2890739395 @default.
• W2600891502 hasRelatedWork W2970673826 @default.
• W2600891502 hasRelatedWork W2996673128 @default.
• W2600891502 hasRelatedWork W3029047934 @default.
• W2600891502 hasRelatedWork W3033772089 @default.

• next