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• W2600906008 startingPage "974" @default.
• W2600906008 abstract "MUFAs are unsaturated FAs with one double bond and are derived from endogenous synthesis and dietary intake. Accumulating evidence has suggested that plasma and erythrocyte MUFA levels are associated with cardiometabolic disorders, including CVD, T2D, and metabolic syndrome (MS). Previous genome-wide association studies (GWASs) have identified seven loci for plasma and erythrocyte palmitoleic and oleic acid levels in populations of European origin. To identify additional MUFA-associated loci and the potential functional variant at each locus, we performed ethnic-specific GWAS meta-analyses and trans-ethnic meta-analyses in more than 15,000 participants of Chinese and European ancestry. We identified novel genome-wide significant associations for vaccenic acid at FADS1/2 and PKD2L1 [log10(Bayes factor) ≥ 8.07] and for gondoic acid at FADS1/2 and GCKR [log10(Bayes factor) ≥ 6.22], and also observed improved fine-mapping resolutions at FADS1/2 and GCKR loci. The greatest improvement was observed at GCKR, where the number of variants in the 99% credible set was reduced from 16 (covering 94.8 kb) to 5 (covering 19.6 kb, including a missense variant rs1260326) after trans-ethnic meta-analysis. We also confirmed the previously reported associations of PKD2L1, FADS1/2, GCKR, and HIF1AN with palmitoleic acid and of FADS1/2 and LPCAT3 with oleic acid in the Chinese-specific GWAS and the trans-ethnic meta-analyses. Pathway-based analyses suggested that the identified loci were in unsaturated FA metabolism and signaling pathways. Our findings provide novel insight into the genetic basis relevant to MUFA metabolism and biology." @default.
• W2600906008 created "2017-04-07" @default.
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• W2600906008 date "2017-05-01" @default.
• W2600906008 modified "2023-10-14" @default.
• W2600906008 title "Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations" @default.
• W2600906008 cites W1973631566 @default.
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• W2600906008 cites W1982514446 @default.
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• W2600906008 cites W2000797253 @default.
• W2600906008 cites W2001907018 @default.
• W2600906008 cites W2006174703 @default.
• W2600906008 cites W2008047653 @default.
• W2600906008 cites W2031149113 @default.
• W2600906008 cites W2039627167 @default.
• W2600906008 cites W2042433654 @default.
• W2600906008 cites W2043601400 @default.
• W2600906008 cites W2053307994 @default.
• W2600906008 cites W2059542829 @default.
• W2600906008 cites W2070176255 @default.
• W2600906008 cites W2080919629 @default.
• W2600906008 cites W2082187068 @default.
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• W2600906008 cites W2144891204 @default.
• W2600906008 cites W2145002256 @default.
• W2600906008 cites W2149791927 @default.
• W2600906008 cites W2152095543 @default.
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• W2600906008 doi "https://doi.org/10.1194/jlr.p071860" @default.
• W2600906008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5408616" @default.
• W2600906008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28298293" @default.
• W2600906008 hasPublicationYear "2017" @default.
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