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- W2600920253 abstract "Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the prevalence of autoantibodies in blood, and systemic inflammation affecting multiple organs such as skin, joints, heart, lungs, brain, and kidneys. Given the elevated incidence of cardiovascular diseases in SLE patients (50 times higher risk than healthy individuals)1 and taking into account the intimate interactions between platelets and the endothelial cells composing blood vessels, Nhek et al2 hypothesized that in SLE, platelets could contribute to endothelial dysfunction. They found that platelets were hyper-reactive in SLE and could induce endothelial cell activation through interleukin-1β (IL-1β). IL-1β is a recognized inflammatory cytokine and its presence in blood correlates with increased risk of cardiovascular disease.3,4 However, its source(s) remains to be determined. This study suggests that platelets may represent a significant source of IL-1β in SLE and could contribute to comorbidities associated with this devastating illness.See accompanying article on page 707 Platelets are small anucleated elements released from the megakaryocytes in the bone marrow and are abundant in blood where they circulate to ensure of the blood vessel integrity.5 There is also accumulating evidence suggesting that platelet functions are not restricted to the hemostatic response. Hence, in addition …" @default.
- W2600920253 created "2017-04-07" @default.
- W2600920253 creator A5042606678 @default.
- W2600920253 date "2017-04-01" @default.
- W2600920253 modified "2023-09-26" @default.
- W2600920253 title "Platelet-Derived Interleukin-1β Fuels the Fire in Blood Vessels in Systemic Lupus Erythematosus" @default.
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- W2600920253 doi "https://doi.org/10.1161/atvbaha.117.309108" @default.
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