FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600932009> ?p ?o ?g. }

• W2600932009 endingPage "390" @default.
• W2600932009 startingPage "389" @default.
• W2600932009 abstract "Lung function is a heritable trait. Heritability estimates posit that approximately30%–50% of the phenotypic variation in FEV1 is explained by genetics,1–3 and genome-wide association studies (GWAS) of lung function4–11 have discovered multiple genetic variants that are associated with cross-sectional measurements in adults of FEV1, FVC and FEV1/FVC ratio at genome-wide significance levels. Many of these same loci have also been implicated in GWAS of COPD. Additional work is required to link these loci to pathophysiology. Functional studies on GWAS loci involving HHIP ,12 ,13 FAM13A ,14 HTR4 ,15 AGER 16 and IREB2 17 have already provided important insights into the biological mechanisms for genetic determinants of COPD and/or lung function.Longitudinal change in lung function (ΔFEV1, ΔFEV1/FVC) is also heritable,18 albeit perhaps to a lesser degree than cross-sectional lung function levels. Although studies of longitudinal lung function have discovered a few loci associated with ΔFEV1 at genome-wide significance levels, none were robust to replication in the available populations. While at first glance the genetic determinants of FEV1 level and ΔFEV1 might be expected to show significant overlap, a recent study of COPD by Lange et al 19 and a complementary study in asthma by McGeachie et al 20 have suggested that low maximum attained lung function and accelerated lung function decline are distinct processes that can exert independent effects on the risk for chronic airflow obstruction. Therefore, it would not be surprising if different genetic determinants influenced cross-sectional and longitudinal lung function change. Longitudinal measurements of lung function are highly informative for identifying these separate processes. In contrast, one …" @default.
• W2600932009 created "2017-04-07" @default.
• W2600932009 creator A5018495347 @default.
• W2600932009 creator A5035524361 @default.
• W2600932009 creator A5072828158 @default.
• W2600932009 date "2017-03-14" @default.
• W2600932009 modified "2023-09-23" @default.
• W2600932009 title "Progress in disease progression genetics: dissecting the genetic origins of lung function decline in COPD" @default.
• W2600932009 cites W1964208294 @default.
• W2600932009 cites W1968225213 @default.
• W2600932009 cites W1968947610 @default.
• W2600932009 cites W2001197270 @default.
• W2600932009 cites W2007669329 @default.
• W2600932009 cites W2028114545 @default.
• W2600932009 cites W2029561500 @default.
• W2600932009 cites W2096764510 @default.
• W2600932009 cites W2096796935 @default.
• W2600932009 cites W2099598799 @default.
• W2600932009 cites W2104443125 @default.
• W2600932009 cites W2107766358 @default.
• W2600932009 cites W2111344085 @default.
• W2600932009 cites W2127175782 @default.
• W2600932009 cites W2149200222 @default.
• W2600932009 cites W2150283886 @default.
• W2600932009 cites W2157186191 @default.
• W2600932009 cites W2157361982 @default.
• W2600932009 cites W2171676943 @default.
• W2600932009 cites W2189024098 @default.
• W2600932009 cites W2258717577 @default.
• W2600932009 cites W2357940608 @default.
• W2600932009 cites W2539344253 @default.
• W2600932009 cites W770714277 @default.
• W2600932009 doi "https://doi.org/10.1136/thoraxjnl-2016-209666" @default.
• W2600932009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28292852" @default.
• W2600932009 hasPublicationYear "2017" @default.
• W2600932009 type Work @default.
• W2600932009 sameAs 2600932009 @default.
• W2600932009 citedByCount "5" @default.
• W2600932009 countsByYear W26009320092018 @default.
• W2600932009 countsByYear W26009320092019 @default.
• W2600932009 countsByYear W26009320092020 @default.
• W2600932009 countsByYear W26009320092021 @default.
• W2600932009 crossrefType "journal-article" @default.
• W2600932009 hasAuthorship W2600932009A5018495347 @default.
• W2600932009 hasAuthorship W2600932009A5035524361 @default.
• W2600932009 hasAuthorship W2600932009A5072828158 @default.
• W2600932009 hasBestOaLocation W26009320091 @default.
• W2600932009 hasConcept C126322002 @default.
• W2600932009 hasConcept C142724271 @default.
• W2600932009 hasConcept C2776780178 @default.
• W2600932009 hasConcept C2777714996 @default.
• W2600932009 hasConcept C2779134260 @default.
• W2600932009 hasConcept C2983914783 @default.
• W2600932009 hasConcept C2992779976 @default.
• W2600932009 hasConcept C3018587741 @default.
• W2600932009 hasConcept C54355233 @default.
• W2600932009 hasConcept C60644358 @default.
• W2600932009 hasConcept C71924100 @default.
• W2600932009 hasConcept C86803240 @default.
• W2600932009 hasConceptScore W2600932009C126322002 @default.
• W2600932009 hasConceptScore W2600932009C142724271 @default.
• W2600932009 hasConceptScore W2600932009C2776780178 @default.
• W2600932009 hasConceptScore W2600932009C2777714996 @default.
• W2600932009 hasConceptScore W2600932009C2779134260 @default.
• W2600932009 hasConceptScore W2600932009C2983914783 @default.
• W2600932009 hasConceptScore W2600932009C2992779976 @default.
• W2600932009 hasConceptScore W2600932009C3018587741 @default.
• W2600932009 hasConceptScore W2600932009C54355233 @default.
• W2600932009 hasConceptScore W2600932009C60644358 @default.
• W2600932009 hasConceptScore W2600932009C71924100 @default.
• W2600932009 hasConceptScore W2600932009C86803240 @default.
• W2600932009 hasIssue "5" @default.
• W2600932009 hasLocation W26009320091 @default.
• W2600932009 hasLocation W26009320092 @default.
• W2600932009 hasOpenAccess W2600932009 @default.
• W2600932009 hasPrimaryLocation W26009320091 @default.
• W2600932009 hasRelatedWork W1574744539 @default.
• W2600932009 hasRelatedWork W2024167655 @default.
• W2600932009 hasRelatedWork W2271798835 @default.
• W2600932009 hasRelatedWork W2363252351 @default.
• W2600932009 hasRelatedWork W2372071230 @default.
• W2600932009 hasRelatedWork W2412532517 @default.
• W2600932009 hasRelatedWork W3023555009 @default.
• W2600932009 hasRelatedWork W3161153624 @default.
• W2600932009 hasRelatedWork W4300958547 @default.
• W2600932009 hasRelatedWork W4312388218 @default.
• W2600932009 hasVolume "72" @default.
• W2600932009 isParatext "false" @default.
• W2600932009 isRetracted "false" @default.
• W2600932009 magId "2600932009" @default.
• W2600932009 workType "article" @default.