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- W2600967565 abstract "The heart is reported to show a net consumption of lactate. This may contribute up to 15% to the total body lactate disposal. In this work, the consumption of lactate was shown for the firsttime on the single cell level with the new FRET-based lactate sensor Laconic.Research published until today, almost exclusively reports the monocarboxylate transporter 1(MCT1) as the transporter responsible for myocardial lactate uptake. As this membranetransporter transports lactate together with H+ in a stoichiometry of 1:1, lactate transport iscoupled to pH regulation. Consequently, interactions of MCT1 and acid/base regulating proteins(carbonic anhydrases (CAs and sodium bicarbonate co-transporters (NBCs)) are described inthe oocyte expression system, skeletal muscle and cancer cells.In this work it is shown that activity of extracellular CA increases lactate uptake into mousecardiomyocytes by 27% and lactate induced JA/B by 42.8% to 46.2%. This effect is most likelymediated via NBC/CA interaction because inhibition of extracellular CA reduces HCO3--dependent acid extruding JA/B by 53.3% to 78.4%. This may link lactate uptake to cellularrespiration. When lactate was applied in medium gassed with 100% N2, lactate inducedacidification was 12.6% faster than in medium gassed with 100% O2. Thus, CO2 produced onthe pathway transferring redox energy from substrates like glucose and lactate to ADP andphosphate via oxidative phosphorylation, may support further lactate uptake. The findings ofthis work suggest an auto regulation of lactate uptake via CO2 release in ventricular mousecardiomyocytes." @default.
- W2600967565 created "2017-04-07" @default.
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- W2600967565 date "2014-01-01" @default.
- W2600967565 modified "2023-09-27" @default.
- W2600967565 title "Lactate uptake into mouse cardiomyocytes is coupled to CO2-dependent acid/base regulation" @default.
- W2600967565 hasPublicationYear "2014" @default.
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