Matches in SemOpenAlex for { <https://semopenalex.org/work/W2600971922> ?p ?o ?g. }
- W2600971922 endingPage "1007" @default.
- W2600971922 startingPage "989" @default.
- W2600971922 abstract "The metabolic flexibility of the opportunistic fungal pathogen Candida albicans is important for colonisation and infection of different host niches. Complex regulatory networks, in which protein kinases play central roles, link metabolism and other virulence-associated traits, such as filamentous growth and stress resistance, and thereby control commensalism and pathogenicity. By screening a protein kinase deletion mutant library that was generated in the present work using an improved SAT1 flipper cassette, we found that the previously uncharacterised kinase Sak1 is a key upstream activator of the protein kinase Snf1, a highly conserved regulator of nutrient stress responses that is essential for viability in C. albicans. The sak1Δ mutants failed to grow on many alternative carbon sources and were hypersensitive to cell wall/membrane stress. These phenotypes were mirrored in mutants lacking other subunits of the SNF1 complex and partially compensated by a hyperactive form of Snf1. Transcriptional profiling of sak1Δ mutants showed that Sak1 ensures basal expression of glyoxylate cycle and gluconeogenesis genes even in glucose-rich media and thereby contributes to the metabolic plasticity of C. albicans. In a mouse model of gastrointestinal colonisation, sak1Δ mutants were rapidly outcompeted by wild-type cells, demonstrating that Sak1 is essential for the in vivo fitness of C. albicans." @default.
- W2600971922 created "2017-04-07" @default.
- W2600971922 creator A5004877297 @default.
- W2600971922 creator A5011368040 @default.
- W2600971922 creator A5025349356 @default.
- W2600971922 creator A5042845365 @default.
- W2600971922 creator A5043353429 @default.
- W2600971922 creator A5060264967 @default.
- W2600971922 creator A5079181760 @default.
- W2600971922 creator A5083018650 @default.
- W2600971922 creator A5089395284 @default.
- W2600971922 date "2017-04-18" @default.
- W2600971922 modified "2023-10-10" @default.
- W2600971922 title "The Snf1-activating kinase Sak1 is a key regulator of metabolic adaptation and<i>in vivo</i>fitness of<i>Candida albicans</i>" @default.
- W2600971922 cites W1582560245 @default.
- W2600971922 cites W1595814741 @default.
- W2600971922 cites W1647692986 @default.
- W2600971922 cites W1834555535 @default.
- W2600971922 cites W1955808217 @default.
- W2600971922 cites W1972091198 @default.
- W2600971922 cites W1983730914 @default.
- W2600971922 cites W1984934366 @default.
- W2600971922 cites W1990474165 @default.
- W2600971922 cites W1992605896 @default.
- W2600971922 cites W2002005828 @default.
- W2600971922 cites W2006754735 @default.
- W2600971922 cites W2025595506 @default.
- W2600971922 cites W2031865039 @default.
- W2600971922 cites W2040362471 @default.
- W2600971922 cites W2040605398 @default.
- W2600971922 cites W2041611856 @default.
- W2600971922 cites W2047373064 @default.
- W2600971922 cites W2047879424 @default.
- W2600971922 cites W2059825898 @default.
- W2600971922 cites W2062396527 @default.
- W2600971922 cites W2067409920 @default.
- W2600971922 cites W2068408380 @default.
- W2600971922 cites W2070380343 @default.
- W2600971922 cites W2073068696 @default.
- W2600971922 cites W2083251705 @default.
- W2600971922 cites W2089940194 @default.
- W2600971922 cites W2091670176 @default.
- W2600971922 cites W2096110497 @default.
- W2600971922 cites W2096258273 @default.
- W2600971922 cites W2100011933 @default.
- W2600971922 cites W2107835138 @default.
- W2600971922 cites W2109476076 @default.
- W2600971922 cites W2116721311 @default.
- W2600971922 cites W2117745265 @default.
- W2600971922 cites W2117954597 @default.
- W2600971922 cites W2122785652 @default.
- W2600971922 cites W2129494864 @default.
- W2600971922 cites W2131942193 @default.
- W2600971922 cites W2133644564 @default.
- W2600971922 cites W2134314989 @default.
- W2600971922 cites W2137044647 @default.
- W2600971922 cites W2137839967 @default.
- W2600971922 cites W2139307267 @default.
- W2600971922 cites W2141878969 @default.
- W2600971922 cites W2153748253 @default.
- W2600971922 cites W2162598371 @default.
- W2600971922 cites W2164306001 @default.
- W2600971922 cites W2166117618 @default.
- W2600971922 cites W2167502710 @default.
- W2600971922 cites W2168986379 @default.
- W2600971922 cites W2170764510 @default.
- W2600971922 cites W2339307955 @default.
- W2600971922 cites W2508106485 @default.
- W2600971922 cites W2535674819 @default.
- W2600971922 cites W2554580095 @default.
- W2600971922 cites W2560088717 @default.
- W2600971922 doi "https://doi.org/10.1111/mmi.13674" @default.
- W2600971922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28337802" @default.
- W2600971922 hasPublicationYear "2017" @default.
- W2600971922 type Work @default.
- W2600971922 sameAs 2600971922 @default.
- W2600971922 citedByCount "31" @default.
- W2600971922 countsByYear W26009719222017 @default.
- W2600971922 countsByYear W26009719222018 @default.
- W2600971922 countsByYear W26009719222019 @default.
- W2600971922 countsByYear W26009719222020 @default.
- W2600971922 countsByYear W26009719222021 @default.
- W2600971922 countsByYear W26009719222022 @default.
- W2600971922 countsByYear W26009719222023 @default.
- W2600971922 crossrefType "journal-article" @default.
- W2600971922 hasAuthorship W2600971922A5004877297 @default.
- W2600971922 hasAuthorship W2600971922A5011368040 @default.
- W2600971922 hasAuthorship W2600971922A5025349356 @default.
- W2600971922 hasAuthorship W2600971922A5042845365 @default.
- W2600971922 hasAuthorship W2600971922A5043353429 @default.
- W2600971922 hasAuthorship W2600971922A5060264967 @default.
- W2600971922 hasAuthorship W2600971922A5079181760 @default.
- W2600971922 hasAuthorship W2600971922A5083018650 @default.
- W2600971922 hasAuthorship W2600971922A5089395284 @default.
- W2600971922 hasBestOaLocation W26009719221 @default.
- W2600971922 hasConcept C104317684 @default.
- W2600971922 hasConcept C143065580 @default.
- W2600971922 hasConcept C145081991 @default.