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- W2600974735 endingPage "419" @default.
- W2600974735 startingPage "409" @default.
- W2600974735 abstract "Variation in regional identity, patterning, and structure of epidermal appendages contributes to skin diversity among many vertebrate groups, and is perhaps most striking in birds. In pioneering work on epidermal appendage patterning, John Saunders and his contemporaries took advantage of epidermal appendage diversity within and among domestic chicken breeds to establish the importance of mesoderm-ectoderm signaling in determining skin patterning. Diversity in chickens and other domestic birds, including pigeons, is driving a new wave of research to dissect the molecular genetic basis of epidermal appendage patterning. Domestic birds are not only outstanding models for embryonic manipulations, as Saunders recognized, but they are also ideal genetic models for discovering the specific genes that control normal development and the mutations that contribute to skin diversity. Here, we review recent genetic and genomic approaches to uncover the basis of epidermal macropatterning, micropatterning, and structural variation. We also present new results that confirm expression changes in two limb identity genes in feather-footed pigeons, a case of variation in appendage structure and identity." @default.
- W2600974735 created "2017-04-07" @default.
- W2600974735 creator A5011748945 @default.
- W2600974735 creator A5069401265 @default.
- W2600974735 creator A5086636287 @default.
- W2600974735 date "2017-09-01" @default.
- W2600974735 modified "2023-10-16" @default.
- W2600974735 title "Genomic determinants of epidermal appendage patterning and structure in domestic birds" @default.
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