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• W2600981364 abstract "Abstract Sedatives are commonly used for mechanically ventilated patients in intensive care units (ICU). However, a variety of sedatives are available and their efficacy and safety have been compared in numerous trials with inconsistent results. To resolve uncertainties regarding usefulness of these sedatives, we performed a systematic review and network meta-analysis. Randomized controlled trials comparing sedatives in mechanically ventilated ICU patients were included. Graph-theoretical methods were employed for network meta-analysis. A total of 51 citations comprising 52 RCTs were included in our analysis. Dexmedetomidine showed shorter MV duration than lorazepam (mean difference (MD): 68.7; 95% CI: 18.2–119.3 hours), midazolam (MD: 10.2; 95% CI: 7.7–12.7 hours) and propofol (MD: 3.4; 95% CI: 0.9–5.9 hours). Compared with dexmedetomidine, midazolam was associated with significantly increased risk of delirium (OR: 2.47; 95% CI: 1.17–5.19). Our study shows that dexmedetomidine has potential benefits in reducing duration of MV and lowering the risk of delirium." @default.
• W2600981364 created "2017-04-07" @default.
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• W2600981364 date "2017-03-21" @default.
• W2600981364 modified "2023-10-17" @default.
• W2600981364 title "Sedation of mechanically ventilated adults in intensive care unit: a network meta-analysis" @default.
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• W2600981364 doi "https://doi.org/10.1038/srep44979" @default.
• W2600981364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5359583" @default.
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• W2600981364 hasPublicationYear "2017" @default.
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