Matches in SemOpenAlex for { <https://semopenalex.org/work/W2601002904> ?p ?o ?g. }
- W2601002904 endingPage "818" @default.
- W2601002904 startingPage "808" @default.
- W2601002904 abstract "Neuronal activity induces intracellular Ca2+ increase, which triggers activation of a series of Ca2+ -dependent signaling cascades. Among these, the multifunctional Ca2+ /calmodulin-dependent protein kinases (CaMKs, or calmodulin kinases) play key roles in neuronal transmission, synaptic plasticity, circuit development and cognition. The most investigated CaMKs for these roles in neuronal functions are CaMKI, CaMKII, CaMKIV and we will shed light on these neuronal CaMKs' functions in this review. Catalytically active members of CaMKs currently are CaMKI, CaMKII, CaMKIV and CaMKK. Although they all necessitate the binding of Ca2+ and calmodulin complex (Ca2+ /CaM) for releasing autoinhibition, each member of CaMK has distinct activation mechanisms-autophosphorylation mediated autonomy of multimeric CaMKII and CaMKK-dependent phosphoswitch-induced activation of CaMKI or CaMKIV. Furthermore, each CaMK shows distinct subcellular localization that underlies specific compartmentalized function in each activated neuron. In this review, we first summarize these molecular characteristics of each CaMK as to regulation and subcellular localization, and then describe each biological function. In the last section, we also focus on the emerging role of CaMKs in pathophysiological conditions by introducing the recent studies, especially focusing on drug addiction and depression, and discuss how dysfunctional CaMKs may contribute to the pathology of the neuropsychological disorders. This article is part of the mini review series 60th Anniversary of the Japanese Society for Neurochemistry." @default.
- W2601002904 created "2017-04-07" @default.
- W2601002904 creator A5004551224 @default.
- W2601002904 creator A5004846865 @default.
- W2601002904 creator A5011706591 @default.
- W2601002904 creator A5019569314 @default.
- W2601002904 creator A5036712866 @default.
- W2601002904 creator A5043086479 @default.
- W2601002904 creator A5058080620 @default.
- W2601002904 creator A5067530544 @default.
- W2601002904 date "2017-04-17" @default.
- W2601002904 modified "2023-10-16" @default.
- W2601002904 title "Calmodulin kinases: essential regulators in health and disease" @default.
- W2601002904 cites W1483057098 @default.
- W2601002904 cites W1483911606 @default.
- W2601002904 cites W1500240510 @default.
- W2601002904 cites W1505515840 @default.
- W2601002904 cites W1511386589 @default.
- W2601002904 cites W1527999680 @default.
- W2601002904 cites W1547944371 @default.
- W2601002904 cites W1587897251 @default.
- W2601002904 cites W1588399796 @default.
- W2601002904 cites W1782908816 @default.
- W2601002904 cites W1810244153 @default.
- W2601002904 cites W1965921788 @default.
- W2601002904 cites W1969477930 @default.
- W2601002904 cites W1976550939 @default.
- W2601002904 cites W1983230142 @default.
- W2601002904 cites W1983719168 @default.
- W2601002904 cites W1984882298 @default.
- W2601002904 cites W1985128738 @default.
- W2601002904 cites W1988241285 @default.
- W2601002904 cites W1989545342 @default.
- W2601002904 cites W1990080386 @default.
- W2601002904 cites W1992949123 @default.
- W2601002904 cites W1993901712 @default.
- W2601002904 cites W1996505874 @default.
- W2601002904 cites W1997907361 @default.
- W2601002904 cites W1998678953 @default.
- W2601002904 cites W1998977808 @default.
- W2601002904 cites W2000500986 @default.
- W2601002904 cites W2003242423 @default.
- W2601002904 cites W2003635901 @default.
- W2601002904 cites W2009728195 @default.
- W2601002904 cites W2010878152 @default.
- W2601002904 cites W2011029903 @default.
- W2601002904 cites W2011327431 @default.
- W2601002904 cites W2011909683 @default.
- W2601002904 cites W2012476009 @default.
- W2601002904 cites W2012985621 @default.
- W2601002904 cites W2013115334 @default.
- W2601002904 cites W2015945228 @default.
- W2601002904 cites W2016721540 @default.
- W2601002904 cites W2017383331 @default.
- W2601002904 cites W2022224180 @default.
- W2601002904 cites W2024962704 @default.
- W2601002904 cites W2026795663 @default.
- W2601002904 cites W2027771105 @default.
- W2601002904 cites W2029638795 @default.
- W2601002904 cites W2034493924 @default.
- W2601002904 cites W2035307512 @default.
- W2601002904 cites W2035831063 @default.
- W2601002904 cites W2035880579 @default.
- W2601002904 cites W2036603867 @default.
- W2601002904 cites W2038232396 @default.
- W2601002904 cites W2042481436 @default.
- W2601002904 cites W2046705260 @default.
- W2601002904 cites W2049134173 @default.
- W2601002904 cites W2049217965 @default.
- W2601002904 cites W2050029180 @default.
- W2601002904 cites W2054975255 @default.
- W2601002904 cites W2061683731 @default.
- W2601002904 cites W2078995190 @default.
- W2601002904 cites W2079193109 @default.
- W2601002904 cites W2079297740 @default.
- W2601002904 cites W2079572118 @default.
- W2601002904 cites W2080152563 @default.
- W2601002904 cites W2082023836 @default.
- W2601002904 cites W2085610167 @default.
- W2601002904 cites W2086121847 @default.
- W2601002904 cites W2087436387 @default.
- W2601002904 cites W2094447195 @default.
- W2601002904 cites W2097860097 @default.
- W2601002904 cites W2099070047 @default.
- W2601002904 cites W2100025585 @default.
- W2601002904 cites W2102038388 @default.
- W2601002904 cites W2103802238 @default.
- W2601002904 cites W2104762573 @default.
- W2601002904 cites W2106389606 @default.
- W2601002904 cites W2108091832 @default.
- W2601002904 cites W2110813649 @default.
- W2601002904 cites W2113755074 @default.
- W2601002904 cites W2113849086 @default.
- W2601002904 cites W2116560077 @default.
- W2601002904 cites W2123128031 @default.
- W2601002904 cites W2123194197 @default.
- W2601002904 cites W2125118099 @default.
- W2601002904 cites W2125824349 @default.