FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2601014906> ?p ?o ?g. }

• W2601014906 endingPage "296" @default.
• W2601014906 startingPage "288" @default.
• W2601014906 abstract "A selective, sensitive and precise assay based on solid phase extraction and liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed for the simultaneous determination of amiloride (AMI) and hydrochlorothiazide (HCTZ) in human plasma. Sample clean-up with 250 µL of plasma was done on Phenomenex Strata™-X extraction cartridges using their labeled internal standards (AMI-15N3 and HCTZ-13C,d2). Chromatography was performed on Hypersil Gold C18 (50 mm×3.0 mm, 5 µm) column using acetonitrile with 4.0 mM ammonium formate (pH 4.0, adjusted with 0.1% formic acid) (80:20, v/v) as the mobile phase. Detection was carried out on a triple quadrupole API 5500 mass spectrometer utilizing an electrospray ionization interface and operating in the positive ionization mode for AMI and negative ionization mode for HCTZ. Multiple reaction monitoring was used following the transitions at m/z 230.6/116.0, m/z 233.6/116.0, m/z 296.0/204.9 and m/z 299.0/205.9 for AMI, AMI-15N3, HCTZ and HCTZ-13C,d2, respectively. Calibration curves were linear (r2≥0.9997) over the concentration range of 0.050-50.0 and 0.50-500 ng/mL for AMI and HCTZ, respectively, with acceptable accuracy and precision. The signal-to-noise ratio at the limit of quantitation was ≥14 for both the analytes. The mean recovery of AMI and HCTZ from plasma was 89.0% and 98.7%, respectively. The IS-normalized matrix factors determined for matrix effect ranged from 0.971 to 1.024 for both the analytes. The validated LC-MS/MS method was successfully applied to a bioequivalence study using 5 mg AMI and 50 mg HCTZ fixed dose tablet formulation in 18 healthy Indian volunteers with good reproducibility." @default.
• W2601014906 created "2017-04-07" @default.
• W2601014906 creator A5055145791 @default.
• W2601014906 creator A5057342881 @default.
• W2601014906 creator A5082609105 @default.
• W2601014906 creator A5091128741 @default.
• W2601014906 date "2017-10-01" @default.
• W2601014906 modified "2023-10-13" @default.
• W2601014906 title "Simultaneous quantification of amiloride and hydrochlorothiazide in human plasma by liquid chromatography–tandem mass spectrometry" @default.
• W2601014906 cites W148885072 @default.
• W2601014906 cites W1908994362 @default.
• W2601014906 cites W1967610947 @default.
• W2601014906 cites W1967989523 @default.
• W2601014906 cites W1977633704 @default.
• W2601014906 cites W1982975241 @default.
• W2601014906 cites W1990252879 @default.
• W2601014906 cites W1991944204 @default.
• W2601014906 cites W1994023107 @default.
• W2601014906 cites W2018733292 @default.
• W2601014906 cites W2021805435 @default.
• W2601014906 cites W2028849364 @default.
• W2601014906 cites W2033373398 @default.
• W2601014906 cites W2046668911 @default.
• W2601014906 cites W2064208151 @default.
• W2601014906 cites W2069569433 @default.
• W2601014906 cites W2082892066 @default.
• W2601014906 cites W2114316419 @default.
• W2601014906 cites W2140449653 @default.
• W2601014906 cites W2163534058 @default.
• W2601014906 cites W2185313016 @default.
• W2601014906 cites W2556333308 @default.
• W2601014906 cites W1931532829 @default.
• W2601014906 doi "https://doi.org/10.1016/j.jpha.2017.03.007" @default.
• W2601014906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5790693" @default.
• W2601014906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29404051" @default.
• W2601014906 hasPublicationYear "2017" @default.
• W2601014906 type Work @default.
• W2601014906 sameAs 2601014906 @default.
• W2601014906 citedByCount "9" @default.
• W2601014906 countsByYear W26010149062018 @default.
• W2601014906 countsByYear W26010149062019 @default.
• W2601014906 countsByYear W26010149062020 @default.
• W2601014906 countsByYear W26010149062021 @default.
• W2601014906 countsByYear W26010149062023 @default.
• W2601014906 crossrefType "journal-article" @default.
• W2601014906 hasAuthorship W2601014906A5055145791 @default.
• W2601014906 hasAuthorship W2601014906A5057342881 @default.
• W2601014906 hasAuthorship W2601014906A5082609105 @default.
• W2601014906 hasAuthorship W2601014906A5091128741 @default.
• W2601014906 hasBestOaLocation W26010149061 @default.
• W2601014906 hasConcept C113196181 @default.
• W2601014906 hasConcept C119128265 @default.
• W2601014906 hasConcept C126838900 @default.
• W2601014906 hasConcept C162356407 @default.
• W2601014906 hasConcept C172493649 @default.
• W2601014906 hasConcept C185592680 @default.
• W2601014906 hasConcept C23531484 @default.
• W2601014906 hasConcept C2775986502 @default.
• W2601014906 hasConcept C2777379063 @default.
• W2601014906 hasConcept C2780361556 @default.
• W2601014906 hasConcept C31827203 @default.
• W2601014906 hasConcept C40684141 @default.
• W2601014906 hasConcept C43617362 @default.
• W2601014906 hasConcept C64489805 @default.
• W2601014906 hasConcept C71043704 @default.
• W2601014906 hasConcept C71924100 @default.
• W2601014906 hasConcept C84393581 @default.
• W2601014906 hasConceptScore W2601014906C113196181 @default.
• W2601014906 hasConceptScore W2601014906C119128265 @default.
• W2601014906 hasConceptScore W2601014906C126838900 @default.
• W2601014906 hasConceptScore W2601014906C162356407 @default.
• W2601014906 hasConceptScore W2601014906C172493649 @default.
• W2601014906 hasConceptScore W2601014906C185592680 @default.
• W2601014906 hasConceptScore W2601014906C23531484 @default.
• W2601014906 hasConceptScore W2601014906C2775986502 @default.
• W2601014906 hasConceptScore W2601014906C2777379063 @default.
• W2601014906 hasConceptScore W2601014906C2780361556 @default.
• W2601014906 hasConceptScore W2601014906C31827203 @default.
• W2601014906 hasConceptScore W2601014906C40684141 @default.
• W2601014906 hasConceptScore W2601014906C43617362 @default.
• W2601014906 hasConceptScore W2601014906C64489805 @default.
• W2601014906 hasConceptScore W2601014906C71043704 @default.
• W2601014906 hasConceptScore W2601014906C71924100 @default.
• W2601014906 hasConceptScore W2601014906C84393581 @default.
• W2601014906 hasIssue "5" @default.
• W2601014906 hasLocation W26010149061 @default.
• W2601014906 hasLocation W26010149062 @default.
• W2601014906 hasLocation W26010149063 @default.
• W2601014906 hasLocation W26010149064 @default.
• W2601014906 hasOpenAccess W2601014906 @default.
• W2601014906 hasPrimaryLocation W26010149061 @default.
• W2601014906 hasRelatedWork W1177195036 @default.
• W2601014906 hasRelatedWork W1985805639 @default.
• W2601014906 hasRelatedWork W2049616422 @default.
• W2601014906 hasRelatedWork W2082209745 @default.
• W2601014906 hasRelatedWork W2329720383 @default.
• W2601014906 hasRelatedWork W2332951358 @default.
• W2601014906 hasRelatedWork W2375352280 @default.

• next