FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2601064120> ?p ?o ?g. }

• W2601064120 endingPage "34" @default.
• W2601064120 startingPage "28" @default.
• W2601064120 abstract "Phosphoethanolamine (pEtN) decoration of E. coli Lipopolysaccharide (LPS) provides resistance to the antimicrobial Polymyxin B (PolB). While EptA and EptB enzymes catalyze the addition of pEtN to the Lipid A and Kdo (pEtN-Kdo-Lipid A), EptC catalyzes the pEtN addition to the Heptose I (pEtN-HeptI). In this study, we investigated the contribution of pEtN-HeptI to PolB resistance using eptA/eptB and eptC deficient E. coli K12 and its wild-type parent strains. These mutations were shown to decrease the antimicrobial activity of PolB on cells grown under pEtN-addition inducing conditions. Furthermore, the 1-N-phenylnapthylamine uptake assay revealed that in vivo PolB has a reduced OM-permeabilizing activity on the ΔeptA/eptB strain compared with the ΔeptC strain. In vitro, the changes in size and zeta potential of LPS-vesicles indicate that pEtN-HeptI reduce the PolB binding, but in a minor extent than pEtN-Kdo-Lipid A. Molecular dynamics analysis revealed the structural basis of the PolB resistance promoted by pEtN-HeptI, which generate a new hydrogen-bonding networks and a denser inner core region. Altogether, the experimental and theoretical assays shown herein indicate that pEtN-HeptI addition promote an LPS conformational rearrangement, that could act as a shield by hindering the accession of PolB to inner LPS-targets moieties." @default.
• W2601064120 created "2017-04-07" @default.
• W2601064120 creator A5000867442 @default.
• W2601064120 creator A5010477463 @default.
• W2601064120 creator A5019582832 @default.
• W2601064120 creator A5047176107 @default.
• W2601064120 creator A5082483772 @default.
• W2601064120 date "2017-04-01" @default.
• W2601064120 modified "2023-10-18" @default.
• W2601064120 title "Phosphoethanolamine addition to the Heptose I of the Lipopolysaccharide modifies the inner core structure and has an impact on the binding of Polymyxin B to the Escherichia coli outer membrane" @default.
• W2601064120 cites W1963646614 @default.
• W2601064120 cites W1964482783 @default.
• W2601064120 cites W1966478139 @default.
• W2601064120 cites W1969493239 @default.
• W2601064120 cites W1975656598 @default.
• W2601064120 cites W1979973356 @default.
• W2601064120 cites W1981338975 @default.
• W2601064120 cites W2004428159 @default.
• W2601064120 cites W2009335524 @default.
• W2601064120 cites W2017369715 @default.
• W2601064120 cites W2021208459 @default.
• W2601064120 cites W2043528043 @default.
• W2601064120 cites W2062347073 @default.
• W2601064120 cites W2066414494 @default.
• W2601064120 cites W2086894122 @default.
• W2601064120 cites W2093738560 @default.
• W2601064120 cites W2105304594 @default.
• W2601064120 cites W2116245384 @default.
• W2601064120 cites W2119921534 @default.
• W2601064120 cites W2134141380 @default.
• W2601064120 cites W2150981663 @default.
• W2601064120 cites W2163568950 @default.
• W2601064120 cites W2171780940 @default.
• W2601064120 cites W2179036997 @default.
• W2601064120 cites W2206954826 @default.
• W2601064120 cites W2314737044 @default.
• W2601064120 cites W2317765000 @default.
• W2601064120 cites W2334841292 @default.
• W2601064120 cites W2518579334 @default.
• W2601064120 cites W2533293950 @default.
• W2601064120 cites W2583196822 @default.
• W2601064120 doi "https://doi.org/10.1016/j.abb.2017.03.008" @default.
• W2601064120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28342805" @default.
• W2601064120 hasPublicationYear "2017" @default.
• W2601064120 type Work @default.
• W2601064120 sameAs 2601064120 @default.
• W2601064120 citedByCount "18" @default.
• W2601064120 countsByYear W26010641202017 @default.
• W2601064120 countsByYear W26010641202018 @default.
• W2601064120 countsByYear W26010641202019 @default.
• W2601064120 countsByYear W26010641202020 @default.
• W2601064120 countsByYear W26010641202021 @default.
• W2601064120 countsByYear W26010641202022 @default.
• W2601064120 countsByYear W26010641202023 @default.
• W2601064120 crossrefType "journal-article" @default.
• W2601064120 hasAuthorship W2601064120A5000867442 @default.
• W2601064120 hasAuthorship W2601064120A5010477463 @default.
• W2601064120 hasAuthorship W2601064120A5019582832 @default.
• W2601064120 hasAuthorship W2601064120A5047176107 @default.
• W2601064120 hasAuthorship W2601064120A5082483772 @default.
• W2601064120 hasConcept C104317684 @default.
• W2601064120 hasConcept C12554922 @default.
• W2601064120 hasConcept C134018914 @default.
• W2601064120 hasConcept C144464004 @default.
• W2601064120 hasConcept C185592680 @default.
• W2601064120 hasConcept C2778754761 @default.
• W2601064120 hasConcept C2780026444 @default.
• W2601064120 hasConcept C2780675486 @default.
• W2601064120 hasConcept C501593827 @default.
• W2601064120 hasConcept C547475151 @default.
• W2601064120 hasConcept C55493867 @default.
• W2601064120 hasConcept C86803240 @default.
• W2601064120 hasConceptScore W2601064120C104317684 @default.
• W2601064120 hasConceptScore W2601064120C12554922 @default.
• W2601064120 hasConceptScore W2601064120C134018914 @default.
• W2601064120 hasConceptScore W2601064120C144464004 @default.
• W2601064120 hasConceptScore W2601064120C185592680 @default.
• W2601064120 hasConceptScore W2601064120C2778754761 @default.
• W2601064120 hasConceptScore W2601064120C2780026444 @default.
• W2601064120 hasConceptScore W2601064120C2780675486 @default.
• W2601064120 hasConceptScore W2601064120C501593827 @default.
• W2601064120 hasConceptScore W2601064120C547475151 @default.
• W2601064120 hasConceptScore W2601064120C55493867 @default.
• W2601064120 hasConceptScore W2601064120C86803240 @default.
• W2601064120 hasLocation W26010641201 @default.
• W2601064120 hasLocation W26010641202 @default.
• W2601064120 hasOpenAccess W2601064120 @default.
• W2601064120 hasPrimaryLocation W26010641201 @default.
• W2601064120 hasRelatedWork W1785910489 @default.
• W2601064120 hasRelatedWork W2048128158 @default.
• W2601064120 hasRelatedWork W2055594561 @default.
• W2601064120 hasRelatedWork W2099814860 @default.
• W2601064120 hasRelatedWork W2108387378 @default.
• W2601064120 hasRelatedWork W2114065630 @default.
• W2601064120 hasRelatedWork W2338946568 @default.
• W2601064120 hasRelatedWork W2438206903 @default.
• W2601064120 hasRelatedWork W2749267305 @default.
• W2601064120 hasRelatedWork W3186241151 @default.

• next