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- W2601110324 abstract "Summary Bacterial adherence to extracellular matrix proteins (ECMp) plays important roles during host–pathogen interaction, however its genetic regulation remains poorly understood. yloA of the model bacterium Bacillus subtilis shows high homology to genes encoding fibronectin‐binding proteins of Gram‐positive pathogens. Here, we characterized the regulatory network of YloA‐dependent adhesive properties of the probiotic B. subtilis natto ( Bs n). YloA‐proficient, but not YloA‐deficient, Bs n specifically bound to ECMp in a concentration‐dependent manner and were proficient in biofilm formation. yloA expression showed a continuous increase in activity during the growth phase and decreased during the stationary phase. The transcription factors AbrB and DegU downregulated yloA expression during the logarithmic and stationary growth phases respectively. Analysis of the yloA promoter region revealed the presence of AT‐rich direct and inverted repeats previously reported to function as DegU‐recognized binding sites. In spo0A cells, yloA expression was completely turned off because of upregulation of AbrB throughout growth. Accordingly, DNase I footprinting analysis confirmed that AbrB bound to the promoter region of yloA . Interestingly, Bs n bound fibronectin with higher affinity, lower Kd , than several bacterial pathogens and competitively excluded them from binding to immobilized‐fibronectin, a finding that might be important for the anti‐infective properties of B. subtilis and its relatives." @default.
- W2601110324 created "2017-04-07" @default.
- W2601110324 creator A5012408534 @default.
- W2601110324 creator A5014570654 @default.
- W2601110324 creator A5021663809 @default.
- W2601110324 creator A5044081498 @default.
- W2601110324 creator A5048190784 @default.
- W2601110324 creator A5061522026 @default.
- W2601110324 creator A5063774188 @default.
- W2601110324 creator A5066656280 @default.
- W2601110324 creator A5085073277 @default.
- W2601110324 date "2017-03-27" @default.
- W2601110324 modified "2023-10-06" @default.
- W2601110324 title "Transcriptional regulation of adhesive properties of<i>Bacillus subtilis</i>to extracellular matrix proteins through the fibronectin-binding protein YloA" @default.
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