Matches in SemOpenAlex for { <https://semopenalex.org/work/W2601255440> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2601255440 abstract "Despite the rapid accumulation of systems-level biological data, understanding the dynamic nature of cellular activity remains a difficult task. The reason is that most biological data are static, or only correspond to snapshots of cellular activity. In this study, we explicitly attempt to detangle the temporal complexity of biological networks by using compilations of time-series gene expression profiling data.We define a dynamic network module to be a set of proteins satisfying two conditions: (1) they form a connected component in the protein-protein interaction (PPI) network; and (2) their expression profiles form certain structures in the temporal domain. We develop the first efficient mining algorithm to discover dynamic modules in a temporal network, as well as frequently occurring dynamic modules across many temporal networks. Using yeast as a model system, we demonstrate that the majority of the identified dynamic modules are functionally homogeneous. Additionally, many of them provide insight into the sequential ordering of molecular events in cellular systems. We further demonstrate that identifying frequent dynamic network modules can significantly increase the signal to noise separation, despite the fact that most dynamic network modules are highly condition-specific. Finally, we note that the applicability of our algorithm is not limited to the study of PPI systems, instead it is generally applicable to the combination of any type of network and time-series data." @default.
- W2601255440 created "2017-04-07" @default.
- W2601255440 creator A5003678652 @default.
- W2601255440 creator A5018647892 @default.
- W2601255440 creator A5070982849 @default.
- W2601255440 creator A5089551267 @default.
- W2601255440 creator A5090336788 @default.
- W2601255440 date "2007-09-24" @default.
- W2601255440 modified "2023-09-23" @default.
- W2601255440 title "Identify Dynamic Network Modules with Temporal and Spatial Constraints" @default.
- W2601255440 hasPublicationYear "2007" @default.
- W2601255440 type Work @default.
- W2601255440 sameAs 2601255440 @default.
- W2601255440 citedByCount "1" @default.
- W2601255440 countsByYear W26012554402015 @default.
- W2601255440 crossrefType "proceedings-article" @default.
- W2601255440 hasAuthorship W2601255440A5003678652 @default.
- W2601255440 hasAuthorship W2601255440A5018647892 @default.
- W2601255440 hasAuthorship W2601255440A5070982849 @default.
- W2601255440 hasAuthorship W2601255440A5089551267 @default.
- W2601255440 hasAuthorship W2601255440A5090336788 @default.
- W2601255440 hasConcept C111919701 @default.
- W2601255440 hasConcept C121332964 @default.
- W2601255440 hasConcept C124101348 @default.
- W2601255440 hasConcept C13540734 @default.
- W2601255440 hasConcept C136764020 @default.
- W2601255440 hasConcept C152662350 @default.
- W2601255440 hasConcept C168167062 @default.
- W2601255440 hasConcept C187191949 @default.
- W2601255440 hasConcept C197298091 @default.
- W2601255440 hasConcept C199360897 @default.
- W2601255440 hasConcept C201797286 @default.
- W2601255440 hasConcept C28225019 @default.
- W2601255440 hasConcept C31258907 @default.
- W2601255440 hasConcept C34947359 @default.
- W2601255440 hasConcept C41008148 @default.
- W2601255440 hasConcept C60644358 @default.
- W2601255440 hasConcept C60723933 @default.
- W2601255440 hasConcept C70721500 @default.
- W2601255440 hasConcept C80444323 @default.
- W2601255440 hasConcept C86803240 @default.
- W2601255440 hasConcept C97355855 @default.
- W2601255440 hasConceptScore W2601255440C111919701 @default.
- W2601255440 hasConceptScore W2601255440C121332964 @default.
- W2601255440 hasConceptScore W2601255440C124101348 @default.
- W2601255440 hasConceptScore W2601255440C13540734 @default.
- W2601255440 hasConceptScore W2601255440C136764020 @default.
- W2601255440 hasConceptScore W2601255440C152662350 @default.
- W2601255440 hasConceptScore W2601255440C168167062 @default.
- W2601255440 hasConceptScore W2601255440C187191949 @default.
- W2601255440 hasConceptScore W2601255440C197298091 @default.
- W2601255440 hasConceptScore W2601255440C199360897 @default.
- W2601255440 hasConceptScore W2601255440C201797286 @default.
- W2601255440 hasConceptScore W2601255440C28225019 @default.
- W2601255440 hasConceptScore W2601255440C31258907 @default.
- W2601255440 hasConceptScore W2601255440C34947359 @default.
- W2601255440 hasConceptScore W2601255440C41008148 @default.
- W2601255440 hasConceptScore W2601255440C60644358 @default.
- W2601255440 hasConceptScore W2601255440C60723933 @default.
- W2601255440 hasConceptScore W2601255440C70721500 @default.
- W2601255440 hasConceptScore W2601255440C80444323 @default.
- W2601255440 hasConceptScore W2601255440C86803240 @default.
- W2601255440 hasConceptScore W2601255440C97355855 @default.
- W2601255440 hasLocation W26012554401 @default.
- W2601255440 hasOpenAccess W2601255440 @default.
- W2601255440 hasPrimaryLocation W26012554401 @default.
- W2601255440 hasRelatedWork W1984478556 @default.
- W2601255440 hasRelatedWork W2032672182 @default.
- W2601255440 hasRelatedWork W2054186937 @default.
- W2601255440 hasRelatedWork W205531469 @default.
- W2601255440 hasRelatedWork W2084529304 @default.
- W2601255440 hasRelatedWork W2120191167 @default.
- W2601255440 hasRelatedWork W2125426727 @default.
- W2601255440 hasRelatedWork W2133628070 @default.
- W2601255440 hasRelatedWork W2140462113 @default.
- W2601255440 hasRelatedWork W2141144378 @default.
- W2601255440 hasRelatedWork W2171662214 @default.
- W2601255440 hasRelatedWork W2287803059 @default.
- W2601255440 hasRelatedWork W2494863456 @default.
- W2601255440 hasRelatedWork W2511552324 @default.
- W2601255440 hasRelatedWork W2516345108 @default.
- W2601255440 hasRelatedWork W2899003199 @default.
- W2601255440 hasRelatedWork W2942369723 @default.
- W2601255440 hasRelatedWork W3203148349 @default.
- W2601255440 hasRelatedWork W60288630 @default.
- W2601255440 hasRelatedWork W987535379 @default.
- W2601255440 isParatext "false" @default.
- W2601255440 isRetracted "false" @default.
- W2601255440 magId "2601255440" @default.
- W2601255440 workType "article" @default.