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• W2601477564 endingPage "84" @default.
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• W2601477564 abstract "To maintain homeostasis in the face of intrinsic and extrinsic insults, cells have evolved elaborate quality control networks to resolve damage at multiple levels. Interorganellar communication is a key requirement for this maintenance, however the underlying mechanisms of this communication have remained an enigma. Here we integrate the outcome of transcriptomic, proteomic, and metabolomics analyses of genotypes including ceh1, a mutant with constitutively elevated levels of both the stress-specific plastidial retrograde signaling metabolite methyl-erythritol cyclodiphosphate (MEcPP) and the defense hormone salicylic acid (SA), as well as the high MEcPP but SA deficient genotype ceh1/eds16, along with corresponding controls. Integration of multi-omic analyses enabled us to delineate the function of MEcPP from SA, and expose the compartmentalized role of this retrograde signaling metabolite in induction of distinct but interdependent signaling cascades instrumental in adaptive responses. Specifically, here we identify strata of MEcPP-sensitive stress-response cascades, among which we focus on selected pathways including organelle-specific regulation of jasmonate biosynthesis; simultaneous induction of synthesis and breakdown of SA; and MEcPP-mediated alteration of cellular redox status in particular glutathione redox balance. Collectively, these integrated multi-omic analyses provided a vehicle to gain an in-depth knowledge of genome-metabolism interactions, and to further probe the extent of these interactions and delineate their functional contributions. Through this approach we were able to pinpoint stress-mediated transcriptional and metabolic signatures and identify the downstream processes modulated by the independent or overlapping functions of MEcPP and SA in adaptive responses." @default.
• W2601477564 created "2017-04-07" @default.
• W2601477564 creator A5004351739 @default.
• W2601477564 creator A5008520002 @default.
• W2601477564 creator A5008717925 @default.
• W2601477564 creator A5014018321 @default.
• W2601477564 creator A5064155641 @default.
• W2601477564 creator A5070484672 @default.
• W2601477564 creator A5071570081 @default.
• W2601477564 creator A5073211263 @default.
• W2601477564 creator A5089878553 @default.
• W2601477564 date "2017-04-29" @default.
• W2601477564 modified "2023-10-17" @default.
• W2601477564 title "Integrated omics analyses of retrograde signaling mutant delineate interrelated stress‐response strata" @default.
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