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• W2601508145 endingPage "e1006234" @default.
• W2601508145 startingPage "e1006234" @default.
• W2601508145 abstract "Non-self recognition is a common phenomenon among organisms; it often leads to innate immunity to prevent the invasion of parasites and maintain the genetic polymorphism of organisms. Fungal vegetative incompatibility is a type of non-self recognition which often induces programmed cell death (PCD) and restricts the spread of molecular parasites. It is not clearly known whether virus infection could attenuate non-self recognition among host individuals to facilitate its spread. Here, we report that a hypovirulence-associated mycoreovirus, named Sclerotinia sclerotiorum mycoreovirus 4 (SsMYRV4), could suppress host non-self recognition and facilitate horizontal transmission of heterologous viruses. We found that cell death in intermingled colony regions between SsMYRV4-infected Sclerotinia sclerotiorum strain and other tested vegetatively incompatible strains was markedly reduced and inhibition barrage lines were not clearly observed. Vegetative incompatibility, which involves Heterotrimeric guanine nucleotide-binding proteins (G proteins) signaling pathway, is controlled by specific loci termed het (heterokaryon incompatibility) loci. Reactive oxygen species (ROS) plays a key role in vegetative incompatibility-mediated PCD. The expression of G protein subunit genes, het genes, and ROS-related genes were significantly down-regulated, and cellular production of ROS was suppressed in the presence of SsMYRV4. Furthermore, SsMYRV4-infected strain could easily accept other viruses through hyphal contact and these viruses could be efficiently transmitted from SsMYRV4-infected strain to other vegetatively incompatible individuals. Thus, we concluded that SsMYRV4 is capable of suppressing host non-self recognition and facilitating heterologous viruses transmission among host individuals. These findings may enhance our understanding of virus ecology, and provide a potential strategy to utilize hypovirulence-associated mycoviruses to control fungal diseases." @default.
• W2601508145 created "2017-04-07" @default.
• W2601508145 creator A5024818901 @default.
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• W2601508145 creator A5041736067 @default.
• W2601508145 creator A5045900539 @default.
• W2601508145 creator A5052237309 @default.
• W2601508145 date "2017-03-23" @default.
• W2601508145 modified "2023-10-06" @default.
• W2601508145 title "Virus-mediated suppression of host non-self recognition facilitates horizontal transmission of heterologous viruses" @default.
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• W2601508145 doi "https://doi.org/10.1371/journal.ppat.1006234" @default.
• W2601508145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5363999" @default.
• W2601508145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28334041" @default.
• W2601508145 hasPublicationYear "2017" @default.
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