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- W2601509136 abstract "Significance Regulatory networks change during evolution. A protein that controls many genes in one species may control a different set of genes in another. We examined how mRNA networks evolve, focusing on the PUF (Pumilio and FBF) family of RNA-binding proteins. These govern stability and translation of hundreds of mRNAs and enable coordinate regulation of discrete biological outcomes. To understand how RNA networks evolve, we used knowledge of the RNA specificity of each PUF protein to predict its mRNA targets and directly identified mRNAs bound to each protein in divergent fungi via biochemical methods. We find networks controlled by one protein switch during evolution to be controlled by another and that proteins with different specificities can share, gain, or lose batteries of mRNAs." @default.
- W2601509136 created "2017-04-07" @default.
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- W2601509136 date "2017-03-20" @default.
- W2601509136 modified "2023-09-27" @default.
- W2601509136 title "Recurrent rewiring and emergence of RNA regulatory networks" @default.
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- W2601509136 doi "https://doi.org/10.1073/pnas.1617777114" @default.
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