FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2601553744> ?p ?o ?g. }

• W2601553744 endingPage "174480691770144" @default.
• W2601553744 startingPage "174480691770144" @default.
• W2601553744 abstract "BackgroundMesenchymal stem cell (MSC) has been one of the potential tools in neuropathic pain therapy; however, the augmented efficacy may be expected when they are modified with human proenkephalin (hPPE) gene. In the current study, the antinociceptive effect of human bone marrow stem cells (hBMSCs) engineered with hPPE gene (hPPE-hBMSCs) on sciatic nerve chronic constriction injury (CCI)-induced neuropathic pain in rats was investigated. MethodsPrimary-cultured hBMSCs were passaged and modified with hPPE, and the cell suspensions (6 × 106) were then intrathecally injected into a rat model of CCI. Paw mechanical withdrawal threshold and paw withdrawal thermal latency were measured before and after CCI surgery. The effects of hPPE gene transfer on hBMSCs bioactivity were analyzed in vitro and in vivo. ResultsNo changes were observed in the surface phenotypes and differentiation of hBMSCs after gene transfer. The hPPE-hBMSC group showed improved paw mechanical withdrawal threshold and paw thermal withdrawal latency values on the ipsilateral side of rats with CCI from day 9 post-surgery, and the analgesic effect was reversed by naloxone. Leucine-enkephalin (L-EK) secretion was augmented in the hPPE-engineered hBMSC group. ConclusionsThe intrathecal administration of BMSCs modified with hPPE gene can effectively relieve pain caused by chronic constriction injury in rats and might be a potentially therapeutic tool for neuropathic pain in humans." @default.
• W2601553744 created "2017-04-07" @default.
• W2601553744 creator A5017764848 @default.
• W2601553744 creator A5024646092 @default.
• W2601553744 creator A5050209085 @default.
• W2601553744 creator A5067878698 @default.
• W2601553744 creator A5080611223 @default.
• W2601553744 date "2017-01-01" @default.
• W2601553744 modified "2023-10-01" @default.
• W2601553744 title "Intrathecal administration of human bone marrow mesenchymal stem cells genetically modified with human proenkephalin gene decrease nociceptive pain in neuropathic rats" @default.
• W2601553744 cites W192799564 @default.
• W2601553744 cites W1941510651 @default.
• W2601553744 cites W1968355662 @default.
• W2601553744 cites W1982568145 @default.
• W2601553744 cites W1985508547 @default.
• W2601553744 cites W2000774114 @default.
• W2601553744 cites W2006351633 @default.
• W2601553744 cites W2012549032 @default.
• W2601553744 cites W2014007136 @default.
• W2601553744 cites W2018320305 @default.
• W2601553744 cites W2020693085 @default.
• W2601553744 cites W2023217015 @default.
• W2601553744 cites W2031163432 @default.
• W2601553744 cites W2034632673 @default.
• W2601553744 cites W2046525806 @default.
• W2601553744 cites W2058020736 @default.
• W2601553744 cites W2067021387 @default.
• W2601553744 cites W2068299260 @default.
• W2601553744 cites W2072849963 @default.
• W2601553744 cites W2074382181 @default.
• W2601553744 cites W2086347487 @default.
• W2601553744 cites W2087110723 @default.
• W2601553744 cites W2093377304 @default.
• W2601553744 cites W2094162828 @default.
• W2601553744 cites W2094320847 @default.
• W2601553744 cites W2098023351 @default.
• W2601553744 cites W2119272706 @default.
• W2601553744 cites W2155097867 @default.
• W2601553744 cites W2158205774 @default.
• W2601553744 cites W2164513741 @default.
• W2601553744 cites W2172201406 @default.
• W2601553744 cites W2264282297 @default.
• W2601553744 cites W2326545304 @default.
• W2601553744 cites W2413085478 @default.
• W2601553744 cites W2415780820 @default.
• W2601553744 cites W2461509873 @default.
• W2601553744 cites W2508396076 @default.
• W2601553744 cites W2638561866 @default.
• W2601553744 cites W4297902471 @default.
• W2601553744 doi "https://doi.org/10.1177/1744806917701445" @default.
• W2601553744 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5391071" @default.
• W2601553744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28326940" @default.
• W2601553744 hasPublicationYear "2017" @default.
• W2601553744 type Work @default.
• W2601553744 sameAs 2601553744 @default.
• W2601553744 citedByCount "11" @default.
• W2601553744 countsByYear W26015537442017 @default.
• W2601553744 countsByYear W26015537442020 @default.
• W2601553744 countsByYear W26015537442021 @default.
• W2601553744 countsByYear W26015537442022 @default.
• W2601553744 crossrefType "journal-article" @default.
• W2601553744 hasAuthorship W2601553744A5017764848 @default.
• W2601553744 hasAuthorship W2601553744A5024646092 @default.
• W2601553744 hasAuthorship W2601553744A5050209085 @default.
• W2601553744 hasAuthorship W2601553744A5067878698 @default.
• W2601553744 hasAuthorship W2601553744A5080611223 @default.
• W2601553744 hasBestOaLocation W26015537441 @default.
• W2601553744 hasConcept C126322002 @default.
• W2601553744 hasConcept C142724271 @default.
• W2601553744 hasConcept C150903083 @default.
• W2601553744 hasConcept C15490471 @default.
• W2601553744 hasConcept C170493617 @default.
• W2601553744 hasConcept C198826908 @default.
• W2601553744 hasConcept C207001950 @default.
• W2601553744 hasConcept C2777107010 @default.
• W2601553744 hasConcept C2777389121 @default.
• W2601553744 hasConcept C2777515746 @default.
• W2601553744 hasConcept C2777803847 @default.
• W2601553744 hasConcept C2780820201 @default.
• W2601553744 hasConcept C2781063702 @default.
• W2601553744 hasConcept C28328180 @default.
• W2601553744 hasConcept C42219234 @default.
• W2601553744 hasConcept C71924100 @default.
• W2601553744 hasConcept C86803240 @default.
• W2601553744 hasConcept C95444343 @default.
• W2601553744 hasConcept C98274493 @default.
• W2601553744 hasConceptScore W2601553744C126322002 @default.
• W2601553744 hasConceptScore W2601553744C142724271 @default.
• W2601553744 hasConceptScore W2601553744C150903083 @default.
• W2601553744 hasConceptScore W2601553744C15490471 @default.
• W2601553744 hasConceptScore W2601553744C170493617 @default.
• W2601553744 hasConceptScore W2601553744C198826908 @default.
• W2601553744 hasConceptScore W2601553744C207001950 @default.
• W2601553744 hasConceptScore W2601553744C2777107010 @default.
• W2601553744 hasConceptScore W2601553744C2777389121 @default.
• W2601553744 hasConceptScore W2601553744C2777515746 @default.
• W2601553744 hasConceptScore W2601553744C2777803847 @default.
• W2601553744 hasConceptScore W2601553744C2780820201 @default.

• next