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- W2601561830 abstract "Purpose: Not much is known on the risk factors for life-threatening arrhythmias in Giant Cell Myocarditis (GCM). Early recognition of high risk enables effective prophylactic treatment of arrhythmias. Methods: Study population consisted of 46 consecutive histologically-verified GCM patients followed in our institution between January 1991 and May 2015. Data of the arrhythmias was retrospectively collected from ECGs, holter data, rhythm strips, and ICD data. All available myocardial biopsy material (n = 44) was analyzed for the extent of myocardial necrosis and fibrosis on a semiquantitative scale from 0 to 3. Summary of results: Of 46 patients, 31 were women and the mean age was 51 ± 12 years. Mean LVEF at presentation was 41 ±15%. After a median of 2 months (range 0 - 82), 26 patients met the primary study endpoint defined as cardiac death (n = 5) or life threatening ventricular arrhythmia (n = 21), whichever occured first. Life-threatening ventricular arrhythmias were defined as treated monomorphic sustained VT (n = 15) or VF (n = 6). After the primary endpoint event, there were three additional cardiac deaths and 7 patients who had VF. The presence of grade 2 to 3 (moderate to severe) necrosis and/or fibrosis on myocardial biopsy predicted worse cardiac survival free of life threatening arrhythmias with a HR of 5.33 (95% CI 1.84 - 15.41). Interestingly, cardiac markers predicted a different set of endpoints: cardiac death or aborted sudden cardiac death (VF). Elevated troponin T (cTnT) above 85 ng/l at the time of presentation and NT-proBNP levels per +1000 ng/l increased the likelihood of cardiac death and/or aborted SCD with a HR of 13.50 (95% CI 1.64 - 110.92) and 1.07 (95% CI 1.01 - 1.14), respectively." @default.
- W2601561830 created "2017-04-07" @default.
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- W2601561830 date "2016-06-01" @default.
- W2601561830 modified "2023-09-24" @default.
- W2601561830 title "219-02: Predictors for Life-Threatening Arrhythmias in Giant Cell Myocarditis" @default.
- W2601561830 doi "https://doi.org/10.1093/europace/18.suppl_1.i187b" @default.
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