FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2601563152> ?p ?o ?g. }

• W2601563152 abstract "Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most frequent cause of inherited Parkinson's disease (PD). The most common PD-associated LRRK2 mutation, G2019S, induces increased production of reactive oxygen species in vitro. We therefore hypothesized that individuals with PD-associated LRRK2 mutations might have increased concentrations of oxidative stress markers and/or decreased total antioxidant capacity (TAC) in their cerebrospinal fluid (CSF). We measured two oxidative stress markers, 8-hydroxy-2’-deoxyguanosine (8-OHdG) and 8-isoprostane (8-ISO), and TAC in CSF from LRRK2 mutation-bearing PD patients (LRRK2 PD = 19), sporadic PD patients (sPD = 31), and healthy control subjects with or without these mutations (LRRK2 CTL = 30, CTL = 27). 8-OHdG and 8-ISO levels were increased in LRRK2 CTL subjects, while TAC was similar between groups. 8-ISO was negatively correlated, and TAC was positively correlated, with Montreal Cognitive Assessment (MoCA) scores in LRRK2 PD, LRRK2 CTL, and CTL subjects. Correlations in both groups of PD patients between the two oxidative stress markers and Unified Parkinson Disease Rating Scale (UPDRS) Total scores were weak, while TAC was negatively correlated with these scores. These findings suggest that oxidative stress may be increased in the CNS in healthy individuals with PD-associated LRRK2 mutations, perhaps contributing to their risk for PD. Further, TAC may decrease in the CNS with the progression of PD, and when cognitive impairment is present regardless of the presence or absence of PD." @default.
• W2601563152 created "2017-04-07" @default.
• W2601563152 creator A5017122855 @default.
• W2601563152 creator A5034276701 @default.
• W2601563152 creator A5042029327 @default.
• W2601563152 creator A5064743664 @default.
• W2601563152 creator A5075719688 @default.
• W2601563152 date "2017-04-03" @default.
• W2601563152 modified "2023-10-18" @default.
• W2601563152 title "Increased Oxidative Stress Markers in Cerebrospinal Fluid from Healthy Subjects with Parkinson’s Disease-Associated LRRK2 Gene Mutations" @default.
• W2601563152 cites W119916385 @default.
• W2601563152 cites W1243203988 @default.
• W2601563152 cites W1277846944 @default.
• W2601563152 cites W1588992136 @default.
• W2601563152 cites W1607814610 @default.
• W2601563152 cites W1964237897 @default.
• W2601563152 cites W1970880865 @default.
• W2601563152 cites W1974200504 @default.
• W2601563152 cites W1981642474 @default.
• W2601563152 cites W1985613988 @default.
• W2601563152 cites W1995191747 @default.
• W2601563152 cites W1996397101 @default.
• W2601563152 cites W1997066981 @default.
• W2601563152 cites W2000396570 @default.
• W2601563152 cites W2004536040 @default.
• W2601563152 cites W2006902704 @default.
• W2601563152 cites W2007635795 @default.
• W2601563152 cites W2008827081 @default.
• W2601563152 cites W2008886854 @default.
• W2601563152 cites W2009964847 @default.
• W2601563152 cites W2010348069 @default.
• W2601563152 cites W2016639408 @default.
• W2601563152 cites W2016654677 @default.
• W2601563152 cites W2020383780 @default.
• W2601563152 cites W2021815999 @default.
• W2601563152 cites W2024747291 @default.
• W2601563152 cites W2025931289 @default.
• W2601563152 cites W2031904885 @default.
• W2601563152 cites W2048202241 @default.
• W2601563152 cites W2052548407 @default.
• W2601563152 cites W2052933564 @default.
• W2601563152 cites W2055619740 @default.
• W2601563152 cites W2072286557 @default.
• W2601563152 cites W2077567337 @default.
• W2601563152 cites W2080752525 @default.
• W2601563152 cites W2088642285 @default.
• W2601563152 cites W2091404872 @default.
• W2601563152 cites W2094332087 @default.
• W2601563152 cites W2097963493 @default.
• W2601563152 cites W2112765817 @default.
• W2601563152 cites W2123714584 @default.
• W2601563152 cites W2124106549 @default.
• W2601563152 cites W2139233019 @default.
• W2601563152 cites W2155634762 @default.
• W2601563152 cites W2162102293 @default.
• W2601563152 cites W2165758561 @default.
• W2601563152 cites W2176451886 @default.
• W2601563152 cites W2319002174 @default.
• W2601563152 cites W2338242470 @default.
• W2601563152 cites W2530923895 @default.
• W2601563152 doi "https://doi.org/10.3389/fnagi.2017.00089" @default.
• W2601563152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5376564" @default.
• W2601563152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28420983" @default.
• W2601563152 hasPublicationYear "2017" @default.
• W2601563152 type Work @default.
• W2601563152 sameAs 2601563152 @default.
• W2601563152 citedByCount "28" @default.
• W2601563152 countsByYear W26015631522018 @default.
• W2601563152 countsByYear W26015631522019 @default.
• W2601563152 countsByYear W26015631522020 @default.
• W2601563152 countsByYear W26015631522021 @default.
• W2601563152 countsByYear W26015631522022 @default.
• W2601563152 countsByYear W26015631522023 @default.
• W2601563152 crossrefType "journal-article" @default.
• W2601563152 hasAuthorship W2601563152A5017122855 @default.
• W2601563152 hasAuthorship W2601563152A5034276701 @default.
• W2601563152 hasAuthorship W2601563152A5042029327 @default.
• W2601563152 hasAuthorship W2601563152A5064743664 @default.
• W2601563152 hasAuthorship W2601563152A5075719688 @default.
• W2601563152 hasBestOaLocation W26015631521 @default.
• W2601563152 hasConcept C126322002 @default.
• W2601563152 hasConcept C134018914 @default.
• W2601563152 hasConcept C147969180 @default.
• W2601563152 hasConcept C167672396 @default.
• W2601563152 hasConcept C203014093 @default.
• W2601563152 hasConcept C2776151105 @default.
• W2601563152 hasConcept C2776632958 @default.
• W2601563152 hasConcept C2779134260 @default.
• W2601563152 hasConcept C2779651940 @default.
• W2601563152 hasConcept C2779734285 @default.
• W2601563152 hasConcept C2780427247 @default.
• W2601563152 hasConcept C2984915365 @default.
• W2601563152 hasConcept C71924100 @default.
• W2601563152 hasConcept C8891405 @default.
• W2601563152 hasConceptScore W2601563152C126322002 @default.
• W2601563152 hasConceptScore W2601563152C134018914 @default.
• W2601563152 hasConceptScore W2601563152C147969180 @default.
• W2601563152 hasConceptScore W2601563152C167672396 @default.
• W2601563152 hasConceptScore W2601563152C203014093 @default.
• W2601563152 hasConceptScore W2601563152C2776151105 @default.

• next